Purification
SiliCycle offers interesting alternative to expedite a wide range of purification typically in the application domains of separation of products mixtures (chromatography) or with SiliaBond®Scavengers, functionalized silica gels designed to react and bind with excess reagents, metal complexes and/or by-products.
Application Notes
All available applications developed for purification purposes are listed below:
For metal removal refer to the following link for more information
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SiliaMetS® Thiol
SiliaMetS® Thiol (Si-Thiol) is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions. It has been used in pharmaceutical processes up to the pilot plant scale. It is our most versatile metal scavenger and is the preferred metal scavenger for Pd(II), Cu, Ag, and Hg.
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SiliaMetS® Thiourea
SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.
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SiliaMetS® Cysteine
SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.
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SiliaMetS® Dimercaptotriazine (DMT)
SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.
TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® Amine nec
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaMetS® Triamine
SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
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SiliaMetS® Imidazole
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
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SiliaMetS® TAAcOH
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
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SiliaMetS® TAAcONa
SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.
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SiliaMetS® Metal Scavenger Kit
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea -
SiliaSep™ Flash Cartridges Amine
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
SiliaSep flash amine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Triamine
SiliaSep flash triamine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Diamine
SiliaSep flash diamine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Thiol
SiliaSep flash thiol cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges TAAcOH
SiliaSep flash TAAcOH cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges TAAcONa
SiliaSep flash TAAcONa cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Thiourea
SiliaSep flash thiourea cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Dimercaptotriazine (DMT)
SiliaSep flash DMT cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Cysteine
SiliaSep flash cysteine cartridges offer a superior alternative to the other cartridges available on the market .
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SiliaSep™ Flash Cartridges - Open Top (OT) Amine
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Open Top (OT) Thiol
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Amine
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Thiol
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Thiourea
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges TAAcOH
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges TAAcONa
SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ 96 Well Plates Amine
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Amine nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaBond® C18 (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.
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SiliaBond® C18 nec (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.
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SiliaBond® C18 (17%)
The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.
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SiliaBond® C18 nec (17%)
This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions. The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.
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SiliaBond® C8
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® C8 nec
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® C4
SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules. It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.
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SiliaBond® C4 nec
SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules. It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.
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SiliaBond® C2
SiliaBond® C2 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds.
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SiliaBond® C2 nec
SiliaBond® C2 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds.
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SiliaBond® C1
SiliaBond® C1 (or C1) has the lowest degree of hydrophobicity of all reversed stationary phases, useful in the separation of large biomolecules that have extensive hydrophobic regions.
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SiliaBond® Phenyl
SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.
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SiliaBond® Phenyl nec
SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.
- Application Fields
- Metal to Remove
- Family / Formats
- Phases
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- Allyl (1)
- Amine (10)
- BTMA Chloride (1)
- C1 (1)
- C12 (2)
- C18 (19)
- C2 (2)
- C4 (3)
- C8 (13)
- Carbonate (4)
- Carboxylic Acid (WCX) (5)
- CleanDRUG (1)
- Cyano (12)
- Cysteine (3)
- Diamine (4)
- Diethylamine (WAX-2) (2)
- Dimercaptotriazine (DMT) (4)
- Diol (1)
- DMAP (1)
- Imidazole (2)
- Isocyanate (1)
- Maleimide (1)
- Phenyl (3)
- Piperazine (1)
- Propylsulfonic Acid (SCX-2) (9)
- SAX (8)
- SCX (6)
- SCX-2 (9)
- Silica (30)
- TAAcOH (4)
- TAAcONa (4)
- TBA Chloride (1)
- TBD (1)
- Thiol (5)
- Thiourea (4)
- TMA Acetate (9)
- TMA Chloride (SAX) (6)
- Tosic Acid (SCX) (8)
- Tosyl Chloride (1)
- Tosyl Hydrazine (1)
- Triamine (4)
- WAX (1)
- WCX (3)
- Pore Size
- Endcapping
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- Endcapped (171)
- Non-endcapped (17)
- Cartridges Volume
- Bed Weight
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- 50 mg (52)
- 100 mg (53)
- 200 mg (34)
- 500 mg (34)
- 1 g (35)
- 2 g (36)
- 4 g (18)
- 5 g (38)
- 8 g (4)
- 9 g (3)
- 10 g (8)
- 12 g (14)
- 15 g (8)
- 20 g (8)
- 25 g (22)
- 40 g (18)
- 45 g (3)
- 50 g (8)
- 65 g (1)
- 70 g (8)
- 80 g (14)
- 90 g (7)
- 100 g (8)
- 120 g (14)
- 135 g (3)
- 200 g (3)
- 220 g (14)
- 330 g (14)
- 350 g (3)
- 400 g (3)
- 800 g (3)
- Particle Size
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- 3 µm (1)
- 5 µm (2)
- 10 µm (2)
- 15 µm (1)
- 20 µm (1)
- 40 µm (1)
- 0-20 µm / 625->2,500 mesh (1)
- 10-30 µm / 475-1,250 mesh (1)
- 5-20 µm / 625-2,500 mesh (1)
- 15-25 µm / 325-625 mesh (2)
- 15-35 µm / 400-940 mesh (2)
- 15-40 µm / 400-1,250 mesh (1)
- 20-45 µm / 325-625 mesh (2)
- 40-63 µm / 230-400 mesh (139)
- 40-75 µm / 200-400 mesh (1)
- 60-120 µm / 70-230 mesh (2)
- 60-200 µm / 70-230 mesh (4)
- 75-200 µm / 60-200 mesh (1)
- 120-200 µm / 70-120 mesh (2)
- 200-500 µm / 35-75 mesh (4)
- 250-500 µm / 35-60 mesh (1)
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