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Cyano Phases For Separation And Extraction

Cyano (CN) sorbents have been extensively used since the mid 1970 for the separation and extraction of very polar compounds that would normally adsorb irreversibly to more common polar phases such as silica. Previously described as an “universal phase”, the advantage of Cyano phase is its ability to provide chromatographic retention both in normal and reversed-phase separation due to its moderate polarity.

Common applications based on Cyano phases include the separation of flavonoids, extraction of polar compounds from non-polar samples as well as the analysis of samples containing analytes with a wide range of hydrophobicity.

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  1. SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Cyano

    SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Cyano

    Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep cartridges for sample loading.

  2. SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Cyano

    SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Cyano

    SiliaSep BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.

    Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.

  3. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano

    SiliaSep BT flash cartridges are compatible with Biotage i-style compression modules.

    Versatile cartridges that can be used either as normal or reversed-phase.  Indicated for products with intermediate polarity.

  4. SiliaSep™ Flash Cartridges - Open Top (OT) Cyano

    SiliaSep™ Flash Cartridges - Open Top (OT) Cyano

    SiliaSep OT flash cartridges are compatible with FlashMaster instrument.

    Versatile cartridges that can be used either as normal or reversed-phase.  Indicated for products with intermediate polarity.

  5. SiliaSep™ Flash Cartridges Cyano

    SiliaSep™ Flash Cartridges Cyano

    Versatile cartridges that can be used either as normal or reversed-phase.  Indicated for products with intermediate polarity.

    SiliaSep flash cyano cartridges offer a superior alternative to the other cartridges available on the market.

  6. SiliaPrep™ 96 Well Plates Cyano nec

    SiliaPrep™ 96 Well Plates Cyano nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  7. SiliaPrep™ 96 Well Plates Cyano

    SiliaPrep™ 96 Well Plates Cyano


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  8. SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.

  9. SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.

  10. SiliaBond® Cyano nec

    SiliaBond® Cyano nec

    SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.

  11. SiliaBond® Cyano

    SiliaBond® Cyano

    SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.

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