1.Typical Experimental Conditions & Calculation
Step 1: Screening
To find out which SiliaBond® Metal Scavenger will better suit your need, we recommend performing some screening (on small scale) using the SiliaBond Metal Scavenger Kit (Product # K30730B) to quickly determine which scavenger presents the highest efficiency and make experiment optimization from there.
Step 2: Optimization
If, upon completion of the screening procedure, the scavenging is not completed and you are not satisfied with the scavenging efficiency or you wish to reduce the number of equivalents and the reaction time, the following steps should be undertaken:
- Increase the temperature of the scavenging reaction
- Modify the number of molar equivalents of the SiliaBond Metal Scavenger Change the reaction time
- Try a different and/or a mixture of SiliaBond Metal Scavengers
These parameters can be changed one at a time or simultaneously to improve the metal removal efficiency. It is important to underline that these scavengers are stable and work in any solvent.
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea