6. Scavenging Rhodium Catalysts
A metal scavenging study using SiliaBond® Metal Scavengers products was conducted on various rhodium catalysts (RhCl3, [Rh(OAc)2]2, Wilkinson’s catalyst) commonly used in organic synthesis.
Various parameters were studied for their influence on the scavengers' robustness as well as to establish the best conditions to bring the level of metal down to an acceptable level for the pharmaceutical industry (i.e.: solvent, number of equivalents, temperature, and reaction time).
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SiliaMetS® Cysteine
SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaMetS® Imidazole
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
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SiliaMetS® TAAcONa
SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.
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- 60 Å (4)
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- Endcapped (4)
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