8. Scavenging A Nickel Catalyst
A metal scavenging study using SiliaBond® Metal Scavengers products was conducted on a nickel catalyst (Ni(acac)2) commonly used in organic synthesis.
Various parameters were studied for their influence on the scavengers' robustness as well as to establish the best conditions to bring the level of metal down to an acceptable level for the pharmaceutical industry (i.e.: solvent, number of equivalents, temperature, and reaction time).
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea