Scavenging Aldehyde/Ketone With SiliaBond® Tosyl Hydrazine
Procedure explaining how to scavenge aldehyde and ketone contained in reaction mixture is presented in this application note.
SiliaBond® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.