Amide & Ester
Amide bond formation is certainly among the most common chemical transformation in organic synthesis. This explains the diversity of possible reaction pathways and reagents available on the market. SiliCycle is part of this trend and this is why we have developed two complementary supported reagents for amide coupling, namely the bound equivalents of 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride) and dicyclohexylcarbodiimide. These two silicas behave similarly but also have their own reactivity particularities and their own procedures. Depending on the reaction conditions, one may be more convenient to use than the other. They also have all the advantages offered by the silica support, i.e. non-swelling, fast reaction kinetics, high recovery, simplified washing procedure, etc.
APPLICATION NOTES
- Use of SiliaBond DMAP
- Use of SiliaBond Carbodiimide
- Use of SiliaBond Dichlorotriazine
- Amide Coupling Using SiliaBond Dichlorotriazine & Carbodiimide
22 Item(s)
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SiliaBond® Dichlorotriazine (DCT)
Amide bond formation is certainly among the most common chemical transformation in organic synthesis. This explains the diversity of possible reaction pathways and reagents available on the market. SiliCycle is part of this trend and this is why we have developed the bound equivalent of 2,4,6-trichloro-1,3,5-triazine(cyanuric chloride), SiliaBond® Dichlorotriazine (Si-DCT).
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® Carbodiimide (DCC)
SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters.
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SiliaBond® Ethyl Carbodiimide (EDC)
SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).
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SiliaBond® DMAP
SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.
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SiliaBond® Reagent Kit
Carbodiimide - Cyanoborohydride - Dichlorotriazine - DMAP - EDC - HOBt -
SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Carbodiimide (DCC)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPlate™ TLC Plates - Glass (G) Silica
Standard normal phase Analytical SiliaPlate™ made with SiliaFlash® silica gel are available on glass backing. Different sizes available.
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SiliaPlate™ TLC Plates - Glass (G - Preparative) Silica
Phase Preparative SiliaPlate™ made with silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) C18
Standard reverse-phase Analytical SiliaPlate™ made with C18 silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) Silver Nitrate (AgNO3) nec
Analytical SiliaPlate™ made with silver nitrate impregnated silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G - Scored) Silica
Standard normal phase Analytical SiliaPlate™ made with SiliaFlash® silica gel are available on scored glass backing. Different sizes available.
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SiliaPlate™ TLC Plates - Glass (G) C8
Standard reverse-phase Analytical SiliaPlate™ made with C8 silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) C2
Standard reverse-phase Analytical SiliaPlate™ made with C2 silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) NH2
Analytical SiliaPlate™ made with amino-functionalized silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) CN
Analytical SiliaPlate™ made with cyano-functionalized silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Glass (G) Diol
Analytical SiliaPlate™ made with diol-functionalized silica gel are available on glass backing.
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SiliaPlate™ TLC Plates - Aluminum (Al) Silica
Standard normal phase Analytical SiliaPlate™ made with SiliaFlash® silica gel are available on aluminum backing. Different sizes available.
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SiliaPrep™ 96 Well Plates Carbonate
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaSep™ Flash Cartridges - Open Top (OT) Carbonate
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
22 Item(s)
List Grid
- Family / Formats
- Phases
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- C18 (1)
- C2 (1)
- C8 (1)
- Carbodiimide (DCC) (3)
- Carbonate (4)
- CN (1)
- Cyanoborohydride (1)
- Dichlorotriazine (DCT) (3)
- Diol (1)
- DMAP (2)
- Ethyl Carbodiimide (EDC) (2)
- HOBt (1)
- NH2 (1)
- Silica (4)
- Silver Nitrate (AgNO3) (1)
- Pore Size
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- 60 Å (10)
- Endcapping
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- Endcapped (20)
- Non-endcapped (1)
- Cartridges Volume
- Bed Weight
- Particle Size
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