1. Use Of SiliaBond® DMAP
SiliaBond® DMAP (or Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as amidation or acetylation. These reactions are well known in organic synthesis and are very useful in various domains. SiliaBond DMAP presents the advantage over its free counterpart as it can be removed by a simple filtration. One of the most important applications for this product is the “Catch and Release” for amide synthesis.
SiliaBond DMAP can also be used in other types of reactions like esterification of alcohols and nucleophilic rearrangements.