3. Use Of SiliaBond® Dichlorotriazine
SiliaBond® DCT must be activated with N-methylmorpholine (NMM) to give a morpholinium salt that can react with the carboxylic acid to form the activated ester. It may then react with an amine to form the amide or safely stored for use at a later date. Si–DCT may also be used for synthesis of Weinreb amides and sulfonamides. Si–DCT provides a fast clean route to generating amides with complete conversion in a little more than an hour compared to most bound coupling reagents, which requires overnight incubation.