4. Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
Amide bond formation is certainly among the most common chemical transformation in organic synthesis. This explains the diversity of possible reaction pathways and reagents available on the market. SiliCycle is part of this trend and this is why we have developed two complementary supported reagents for amide coupling, namely the bound equivalents of 2,4,6-trichloro-1,3,5-triazine (cyanuric chloride): SiliaBond® Dichlorotriazine and of dicyclohexylcarbodiimide : SiliaBond Carbodiimide.
These two silicas behave similarly but also have their own reactivity particularities and their own procedures. Depending on the reaction conditions, one may be more convenient to use than the other. They also have all the advantages offered by the silica support, i.e. non-swelling, fast reaction kinetics, high recovery, simplified washing procedure, etc.
SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).