SiliCycle offers silica-based products that can be used in organic synthesis in replacement of homogeneous equivalents. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are also suitable for use in batch reactions and in flow through applications.
All available applications developed for synthesis purposes are listed below:
- Common Organic Reactions
For amide and ester synthesis refer to the following link for more information
- Use of SiliaBond Cyanoborohydride
- Use of SiliaBond Carbonate
- Difference Between SiliaBond PCC & PDC: When to Use Them?
- SiliaBond Reagents Kit for Microwave Applications
Amine - Carbonate - Dimethylamine - Diethylamine - Morpholine - Pyridine - TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.