The nanomaterials discovered at the Italian Institute for the Study of Nanostructured Materials of the National Research Council (CNR-ISMN) in Palermo apply to the most important reactions in modern organic chemistry.
Rome, June 9, 2011 – The discovery of a new class of multipotent heterogeneous catalysts by the Italian National Research Council offers new ways to achieve in a clean and faster manner, the three main reactions of organic chemistry used in almost all production processes in the pharmaceutical industry, namely the carbon-carbon coupling, the hydrogenation, and debenzylation.
Made in Palermo, at the Laboratory of Mario Pagliaro and Rosaria Ciriminna from the Institute for the Study of Nanostructured Materials of the CNR, the discovery and the first related applications - which include reactions for which was awarded the Nobel Prize in Chemistry 2010 – have been published in the scientific journals ChemCatChem, Advanced Synthesis & Catalysis, and Catalysis Science & Technology.
“With only one-twentieth of the amount of products commonly used - says Pagliaro - these materials are an example of the tremendous potential offered by nanochemistry to the pharmaceutical industry. This new class of catalysts operates at room temperature, and are fully recyclable since they can be removed by a simple filtration - Pagliaro concludes.”
Almost all drugs are in fact produced using catalytic processes that make use of catalysts, ie substances capable in small quantities to accelerate the course of a chemical reaction. The problem is that these processes are carried out in solution with dissolved catalysts. The result is that before being put on the market, the drugs must be purified from the catalysts and this process is very expensive for pharmaceuticals.
Accordingly, the pharmaceutical industry - which has a huge volume of business (over $ 600 billion in 2010) - has long been looking for new processes able to reduce the economic burden due to environmental and traditional processes.
The SiliaCat Pd (0), and SiliaCat Pt (0), are nanomaterials that will be soon offered on the market by the Canadian chemical manufacturer SiliCycle Inc. These new silica based heterogeneous catalysts can be applied to a wide range of industrial processes with the economic and environmental benefits that have long been searched for by the fine chemicals industries, such as pharmaceuticals.
Who: Institute for the Study of Nanostructured Materials of the CNR, Palermo
What: The Italian National Research Council (CNR) Discovers New Multipotent Heterogeneous Catalysts that are able to effectively promote and clean the main reactions of organic chemistry - study published in ChemCatChem, Advanced Synthesis & Catalysis, and Catalysis Science & Technology.
A new class of heterogeneous Pd catalysts for synthetic organic chemistry
Mario Pagliaro, Valerica Pandarus, Francois Béland, Rosaria Ciriminna, Giovanni Palmisano and Piera Demma Carà
Catal. Sci. Technol., 2011, Advance Article
DOI: 10.1039/C1CY00119A
Received 01 Apr 2011, Accepted 15 Apr 2011
First published on the web 09 May 2011
A New Class of Heterogeneous Platinum Catalysts for the Chemoselective Hydrogenation of Nitroarenes
- Valerica Pandarus1,
- Rosaria Ciriminna2,
- François Béland1,*,
- Mario Pagliaro2,*
Article first published online: 17 MAY 2011
DOI: 10.1002/adsc.201000945
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Selective Debenzylation of Benzyl Protected Groups with SiliaCat Pd(0) under Mild Conditions
- Dr. Valerica Pandarus1,
- Dr. François Béland1,
- Dr. Rosaria Ciriminna2,
- Dr. Mario Pagliaro2
Article first published online: 21 APR 2011
DOI: 10.1002/cctc.201000420
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Selective hydrogenation of functionalized nitroarenes under mild conditions
Valerica Pandarus, Rosaria Ciriminna, François Béland and Mario Pagliaro
Catal. Sci. Technol., 2011, Advance Article
DOI: 10.1039/C1CY00097G, Paper
For information: Mario Pagliaro, l’Istituto per lo Studio dei Materiali Nanostrutturati del CNR di Palermo, email: mario.pagliaro@cnr.it, tel. 091 680 93 70, Web: www.qualitas1998.net
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