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Drug Development

SiliCycle designs, develops, and manufactures innovative products for world class pharmaceutical companies with gram to multi-tons production capabilities. For large scale purifications, our state-of-the-art facilities allow us to produce high quality chromatographic phases in large batches to supply the most demanding applications.

We are also producing large amount of metal scavengers for the selective removal of spent metal catalysts traces from active pharmaceutical ingredients (API). These ligands bound to silica gel, in bulk or in cartridge formats, are especially designed to remove metal traces down to single digit ppm levels fast and reproducibly. A simple filtration is then performed to get rid of the silica scavenger with the metals entrapped.

We are also producing high quality chromatographic phases for any separation project, large or small. We can supply large quantities of normal, reverse, and ion-exchange phases that will give you the best performance at a competitive price.

Our new line of SiliaCat® heterogeneous catalysts are also very valuable tools for scale-up and process. These catalysts are easy to use and very efficient. At the end of the reaction, a simple filtration removes the spent catalyst and leaves the reaction mixture free of any metal traces.

Furthermore, our technical experts are always there to assist you with any question or to guide you in any given application.

We are your number 1 metal removal solution provider, and your partner of choice for your synthesis, catalysis, analysis and all of your purification requirements.

We commit ourselves to offer you best quality products for price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

    • CONTACT US for more details

Extensive Technical Support:

  • Our team of dedicated specialist will answer your questions, no matter how technical they are.

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  1. SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).

  2. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  3. SiliaMetS® Thiourea

    SiliaMetS® Thiourea

    SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.

  4. SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.

    TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.

  5. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  6. SiliaMetS® Cysteine

    SiliaMetS® Cysteine

    SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.

  7. SiliaSep™ XL Flash Cartridges Silica

    SiliaSep™ XL Flash Cartridges Silica

    SiliaSep flash cartridges offer a superior alternative to the other cartridges available on the market as they present the following characteristics:

  8. SiliaCat® Heterogeneous Catalysts DPP-Pd

    SiliaCat® Heterogeneous Catalysts DPP-Pd

    The significant costs associated with precious metal catalysts and their undesired tendency to remain in organic products has generated interest for an increase in reactivity and ways to recover and reuse these metals. SiliaCat® DPP-Pd is a unique diphenylphosphine palladium (II) heterogeneous catalysts made from a leach-resistant organoceramic matrix.

  9. SiliaCat® Heterogeneous Catalysts S-Pd

    SiliaCat® Heterogeneous Catalysts S-Pd

    The significant costs associated with precious metal catalysts and their undesired tendency to remain in organic products has generated interest for an increase in reactivity and ways to recover and reuse these metals. SiliaCat® S-Pd is a unique thiol based palladium (II) heterogeneous catalysts made from a leach-resistant organoceramic matrix.

  10. SiliaCat® Heterogeneous Catalysts TEMPO

    SiliaCat® Heterogeneous Catalysts TEMPO

    SiliaCat® TEMPO is a heterogeneous catalyst/reagent made from a proprietary class of organosilica-entrapped radicals suitable for the selective oxidation of delicate substrates into valued carbonyl derivatives.

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Filter By
Metal to Remove
Silver (Ag)
  1. Preferred Scavengers (4)
  2. Scavenge (3)
Calcium (Ca)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Cadmium (Cd)
  1. Preferred Scavengers (13)
  2. Scavenge (7)
Cobalt (Co)
  1. Preferred Scavengers (4)
  2. Scavenge (17)
Chromium (Cr)
  1. Preferred Scavengers (14)
  2. Scavenge (9)
Cesium (Cs)
  1. Preferred Scavengers (3)
  2. Scavenge (5)
Copper (Cu)
  1. Preferred Scavengers (4)
  2. Scavenge (26)
Iron (Fe)
  1. Preferred Scavengers (6)
  2. Scavenge (23)
Mercury (Hg)
  1. Preferred Scavengers (4)
  2. Scavenge (11)
Iridium (Ir)
  1. Preferred Scavengers (8)
  2. Scavenge (4)
Lanthanum (La)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Lithium (Li)
  1. Preferred Scavengers (3)
Magnesium (Mg)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Nickel (Ni)
  1. Preferred Scavengers (9)
  2. Scavenge (8)
Osmium (Os)
  1. Preferred Scavengers (15)
  2. Scavenge (4)
Lead (Pb)
  1. Preferred Scavengers (3)
  2. Scavenge (15)
Palladium (Pd-2+)
  1. Preferred Scavengers (17)
  2. Scavenge (16)
Palladium (Pd-0)
  1. Preferred Scavengers (17)
  2. Scavenge (9)
Platinum (Pt)
  1. Preferred Scavengers (17)
  2. Scavenge (2)
Rhodium (Rh-1+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-2+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-3+)
  1. Preferred Scavengers (6)
  2. Scavenge (7)
Ruthenium (Ru-2+)
  1. Preferred Scavengers (5)
  2. Scavenge (14)
Scandium (Sc)
  1. Preferred Scavengers (8)
  2. Scavenge (10)
Tin (Sn)
  1. Preferred Scavengers (5)
  2. Scavenge (10)
Tungsten (W)
  1. Preferred Scavengers (2)
  2. Scavenge (13)
Zinc (Zn)
  1. Preferred Scavengers (1)
  2. Scavenge (22)
Scavenge Others
  1. Scavenge (1)
Family / Formats
  1. Micro Tube (9)
  2. SiliaBond® (Functionalized Silicas) (40)
  3. SiliaCat® (Heterogeneous Catalysts) (3)
  4. SiliaFlash® (Irregular Silicas) (26)
  5. SiliaMetS® (Metal Scavengers) (8)
  6. SiliaSep™ (Flash Cartridges) (54)
  7. SiliaSphere™ (Spherical Silicas) (2)
  8. SiliaPrep™ (SPE Cartridges) (26)
Phases
  1. Amine (10)
  2. Amino (1)
  3. C18 (19)
  4. C8 (4)
  5. Carbodiimide (DCC) (3)
  6. Carbonate (4)
  7. Carboxylic Acid (WCX) (2)
  8. Cyano (5)
  9. Cyanoborohydride (2)
  10. Cysteine (4)
  11. Diamine (6)
  12. Dichlorotriazine (DCT) (3)
  13. Diethylamine (1)
  14. Dimercaptotriazine (DMT) (5)
  15. Dimethylamine (1)
  16. Diol (5)
  17. Diphenylphosphine (1)
  18. DMAP (2)
  19. DPP-Pd (1)
  20. Ethyl Carbodiimide (EDC) (2)
  21. Fluorochrom (2)
  22. HOBt (1)
  23. Imidazole (3)
  24. Morpholine (1)
  25. Piperazine (1)
  26. Potassium Permanganate (2)
  27. Propylsulfonic Acid (SCX-2) (8)
  28. Pyridine (1)
  29. Pyridinium Chlorochromate (PCC) (2)
  30. Pyridinium Dichromate (PDC) (2)
  31. S-Pd (1)
  32. SCX (1)
  33. SCX-2 (1)
  34. Silica (36)
  35. TAAcOH (6)
  36. TAAcONa (5)
  37. TBD (2)
  38. TEMPO (2)
  39. Thiol (6)
  40. Thiourea (5)
  41. TMA Acetate (4)
  42. TMA Chloride (SAX) (2)
  43. Tosic Acid (SCX) (7)
  44. Tosyl Hydrazine (1)
  45. Triamine (6)
Pore Size
  1. 40 Å (4)
  2. 60 Å (130)
  3. 70 Å (1)
  4. 90 Å (4)
  5. 100 Å (1)
  6. 120 Å (1)
  7. 150 Å (3)
  8. 300 Å (4)
  9. 500 Å (1)
  10. 1000 Å (2)
  11. 25-70 Å (3)
Endcapping
  1. Endcapped (141)
  2. Non-endcapped (32)
Cartridges Volume
  1. 1 500 mL (1)
  2. 123 mL (1)
  3. 17 mL (1)
  4. 190 mL (1)
  5. 2 900 mL (1)
  6. 306 mL (1)
  7. 31 mL (1)
  8. 4.9 mL (1)
  9. 441 mL (1)
  10. 47 mL (1)
  11. 1 mL (21)
  12. 2 mL (9)
  13. 3 mL (25)
  14. 6 mL (26)
  15. 10 mL (6)
  16. 12 mL (26)
  17. 25 mL (28)
  18. 60 mL (3)
  19. 70 mL (13)
  20. 150 mL (19)
  21. 276 mL (13)
  22. 700 mL (3)
Bed Weight
  1. 50 mg (29)
  2. 100 mg (21)
  3. 200 mg (25)
  4. 500 mg (25)
  5. 1 g (26)
  6. 2 g (31)
  7. 4 g (27)
  8. 5 g (38)
  9. 8 g (8)
  10. 9 g (7)
  11. 10 g (14)
  12. 12 g (19)
  13. 15 g (13)
  14. 20 g (13)
  15. 25 g (35)
  16. 40 g (27)
  17. 45 g (7)
  18. 50 g (13)
  19. 65 g (6)
  20. 70 g (13)
  21. 80 g (19)
  22. 90 g (15)
  23. 100 g (13)
  24. 120 g (19)
  25. 135 g (7)
  26. 200 g (7)
  27. 220 g (18)
  28. 270 g (3)
  29. 330 g (18)
  30. 350 g (7)
  31. 400 g (7)
  32. 800 g (10)
  33. 1600 g (3)
Particle Size
  1. 3 µm (1)
  2. 5 µm (1)
  3. 10 µm (1)
  4. 15 µm (1)
  5. 0-20 µm (1)
  6. 10-30 µm (1)
  7. 5-20 µm (1)
  8. 15-25 µm (2)
  9. 15-35 µm (2)
  10. 15-40 µm (2)
  11. 20-45 µm (2)
  12. 40-63 µm (121)
  13. 40-75 µm (1)
  14. 60-120 µm (2)
  15. 60-200 µm (4)
  16. 63-250 µm (3)
  17. 75-200 µm (1)
  18. 120-200 µm (2)
  19. 200-500 µm (4)
  20. 250-500 µm (1)

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Testimonials

“The high quality nature of the columns and plates from SiliCycle has allowed us to achieve a level of reproducibility with our compound libraries that would be unheard of with any other production line.”
[Steven Marois, Boston University CMLD]

“Several of my teams have successfully employed SiliCycle resins to scavenge metals from APIs. The fact that these scavengers work so well allow us to employ Pd-catalyzed cross couplings as final steps in API synthetic sequences confidently, knowing that we will likely be able to reduce transition metal contamination to acceptable levels in the final drug substance.”
[Akin Davulcu, Bristol-Myers Squibb]

“BioVectra has been able to leverage its large scale chromatography capability with the technical and product capability of the SiliCyle team into the manufacturing of important oncology active pharma ingredients. We have been associated with SiliCycle since 1998, and look forward to working together on many new projects in the future.”
[Dale Zajicek, BioVectra]

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© 2012 SiliCycle.

Worldwide Headquarters SiliCycle Inc., 2500, Parc-Technologique Blvd, Quebec City (Quebec) G1P 4S6, CANADA
Phone: 1 418.874.0054 Toll Free: 1 877.745.4292 (North America only)
Fax: 1 418.874.0355 E-mail: info@silicycle.com
Copyright © 2011 SiliCycle Inc. All rights reserved.