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Drug Development

SiliCycle designs, develops, and manufactures innovative products for world class pharmaceutical companies with gram to multi-tons production capabilities. For large scale purifications, our state-of-the-art facilities allow us to produce high quality chromatographic phases in large batches to supply the most demanding applications.

We are also producing large amount of metal scavengers for the selective removal of spent metal catalysts traces from active pharmaceutical ingredients (API). These ligands bound to silica gel, in bulk or in cartridge formats, are especially designed to remove metal traces down to single digit ppm levels fast and reproducibly. A simple filtration is then performed to get rid of the silica scavenger with the metals entrapped.

We are also producing high quality chromatographic phases for any separation project, large or small. We can supply large quantities of normal, reverse, and ion-exchange phases that will give you the best performance at a competitive price.

Our new line of SiliaCat® heterogeneous catalysts are also very valuable tools for scale-up and process. These catalysts are easy to use and very efficient. At the end of the reaction, a simple filtration removes the spent catalyst and leaves the reaction mixture free of any metal traces.

Furthermore, our technical experts are always there to assist you with any question or to guide you in any given application.

We are your number 1 metal removal solution provider, and your partner of choice for your synthesis, catalysis, analysis and all of your purification requirements.

We commit ourselves to offer you best quality products for price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

    • CONTACT US for more details

Extensive Technical Support:

  • Our team of dedicated specialist will answer your questions, no matter how technical they are.

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  1. SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).

  2. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  3. SiliaMetS® Thiourea

    SiliaMetS® Thiourea

    SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.

  4. SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.

    TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.

  5. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  6. SiliaMetS® Cysteine

    SiliaMetS® Cysteine

    SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.

  7. SiliaSep™ XL Flash Cartridges Silica

    SiliaSep™ XL Flash Cartridges Silica

    SiliaSep flash cartridges offer a superior alternative to the other cartridges available on the market as they present the following characteristics:

  8. SiliaCat® Heterogeneous Catalysts DPP-Pd

    SiliaCat® Heterogeneous Catalysts DPP-Pd

    The significant costs associated with precious metal catalysts and their undesired tendency to remain in organic products has generated interest for an increase in reactivity and ways to recover and reuse these metals. SiliaCat® DPP-Pd is a unique diphenylphosphine palladium (II) heterogeneous catalysts made from a leach-resistant organoceramic matrix.

  9. SiliaCat® Heterogeneous Catalysts S-Pd

    SiliaCat® Heterogeneous Catalysts S-Pd

    The significant costs associated with precious metal catalysts and their undesired tendency to remain in organic products has generated interest for an increase in reactivity and ways to recover and reuse these metals. SiliaCat® S-Pd is a unique thiol based palladium (II) heterogeneous catalysts made from a leach-resistant organoceramic matrix.

  10. SiliaCat® Heterogeneous Catalysts TEMPO

    SiliaCat® Heterogeneous Catalysts TEMPO

    SiliaCat® TEMPO is a heterogeneous catalyst/reagent made from a proprietary class of organosilica-entrapped radicals suitable for the selective oxidation of delicate substrates into valued carbonyl derivatives.

  11. SiliaBond® Potassium Permanganate nec

    SiliaBond® Potassium Permanganate nec

    Potassium permanganate is a strong oxidant that will oxidize methyl groups and alcohols to carboxylic acids. SiliaBond® Potassium Permanganate (Si-KMnO4) increases recoveries, facilitates work-up, and expands the scope of the chemistry because it can be used in all organic solvents eliminating solubility issues. With SiliaBond Potassium Permanganate, the manganese salt by-products stays adsorbed onto the silica.

  12. SiliaBond® Pyridinium Chlorochromate nec (PCC)

    SiliaBond® Pyridinium Chlorochromate nec (PCC)

    SiliaBond® Pyridinium Chlorochromate (Si-PCC) is used for the general oxidation of alcohols to carbonyl compounds, selective oxidation of allylic and benzylic alcohols, organometallic oxidation, oxidative transpositions, oxidative cleavages, allylic and benzylic oxidation and oxidative cyclizations.


  13. SiliaBond® Pyridinium Dichromate nec (PDC)

    SiliaBond® Pyridinium Dichromate nec (PDC)

    SiliaBond® Pyridinium Dichromate (Si-PDC) may be used as an alternative to Si-PCC in nucleoside and carbohydrate oxidation, particularly for fragile molecules. SiliaBond PDC can also be used in conjunction with tertbutylhydroperoxide for a variety of oxidative transformations.

  14. SiliaBond® C18 (23%)

    SiliaBond® C18 (23%)

    SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.

  15. SiliaBond® C18 nec (23%)

    SiliaBond® C18 nec (23%)

    SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.

  16. SiliaBond® C18 (17%)

    SiliaBond® C18 (17%)

    The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.

  17. SiliaBond® C18 nec (17%)

    SiliaBond® C18 nec (17%)

    This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions.  The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.

  18. SiliaBond® C18 (11%)

    SiliaBond® C18 (11%)

    SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.

  19. SiliaBond® Diphenylphosphine

    SiliaBond® Diphenylphosphine

    SiliaBond® Diphenylphosphine (Si-DPP) can be used as linker for catalyst immobilization such as tetrakis-(triphenylphosphine)palladium(0) for Suzuki coupling.

  20. SiliaBond® Propylsulfonic Acid (SCX-2)

    SiliaBond® Propylsulfonic Acid (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  21. SiliaBond® Propylsulfonic Acid nec (SCX-2)

    SiliaBond® Propylsulfonic Acid nec (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  22. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  23. SiliaBond® Dichlorotriazine (DCT)

    SiliaBond® Dichlorotriazine (DCT)

    Amide bond formation is certainly among the most common chemical transformation in organic synthesis. This explains the diversity of possible reaction pathways and reagents available on the market. SiliCycle is part of this trend and this is why we have developed the bound equivalent of 2,4,6-trichloro-1,3,5-triazine(cyanuric chloride), SiliaBond® Dichlorotriazine (Si-DCT).

  24. SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.


  25. SiliaBond® Tosic Acid (SCX)

    SiliaBond® Tosic Acid (SCX)

    SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.


  26. SiliaBond® Carbonate

    SiliaBond® Carbonate

    SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  27. SiliaBond® TMA Acetate nec

    SiliaBond® TMA Acetate nec

    Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.

  28. SiliaBond® Cyanoborohydride

    SiliaBond® Cyanoborohydride

    SiliaBond® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica.

  29. SiliaBond® Carbodiimide (DCC)

    SiliaBond® Carbodiimide (DCC)

    SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters.

  30. SiliaBond® Ethyl Carbodiimide (EDC)

    SiliaBond® Ethyl Carbodiimide (EDC)

    SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).

  31. SiliaMetS® Metal Scavenger Kit

    SiliaMetS® Metal Scavenger Kit

    Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea
  32. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  33. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  34. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  35. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  36. SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  37. SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  38. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  39. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  40. SiliaFlash® Irregular Silica Gels - S40 Silica

    SiliaFlash® Irregular Silica Gels - S40 Silica

    SiliCycle offers a wide selection of silica gels with pore size of 40 Å including particle size distribution of 15-35 µm  for high performance chromatography purposes.

  41. SiliaFlash® Irregular Silica Gels - F40 Silica

    SiliaFlash® Irregular Silica Gels - F40 Silica

    SiliCycle offers a wide selection of silica gels with pore size of 40 Å including particle size distribution of 40-63 µm  for flash chromatography purposes.

  42. SiliaFlash® Irregular Silica Gels - G40 Silica

    SiliaFlash® Irregular Silica Gels - G40 Silica

    SiliCycle offers a wide selection of silica gels with pore size of 40 Å including particle size distribution of 60-200 µm  for gravity chromatography purposes.

  43. SiliaFlash® Irregular Silica Gels - B40 Silica

    SiliaFlash® Irregular Silica Gels - B40 Silica

    SiliCycle offers a wide selection of silica gels with pore size of 40 Å including particle size distribution of 200-500 µm  for gravity chromatography purposes.

  44. SiliaFlash® Irregular Silica Gels - C60 Silica (0-20 µm)

    SiliaFlash® Irregular Silica Gels - C60 Silica (0-20 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 0-20 µm  for thin layer chromatography purposes.

  45. SiliaFlash® Irregular Silica Gels - I60 Silica (15-25 µm)

    SiliaFlash® Irregular Silica Gels - I60 Silica (15-25 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 15-25 µm  for high performance chromatography purposes.

  46. SiliaFlash® Irregular Silica Gels - A60 Silica (5-20 µm)

    SiliaFlash® Irregular Silica Gels - A60 Silica (5-20 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 5-20 µm  for thin layer chromatography purposes.

  47. SiliaFlash® Irregular Silica Gels - S60 Silica (15-35 µm)

    SiliaFlash® Irregular Silica Gels - S60 Silica (15-35 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 15-35 µm  for high performance chromatography purposes.

  48. SiliaFlash® Irregular Silica Gels - E60 Silica (15-40 µm)

    SiliaFlash® Irregular Silica Gels - E60 Silica (15-40 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 10-40 µm  for high performance chromatography purposes.

  49. SiliaFlash® Irregular Silica Gels - D60 Silica (10-30 µm)

    SiliaFlash® Irregular Silica Gels - D60 Silica (10-30 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 10-30 µm  for high performance chromatography purposes.

  50. SiliaFlash® Irregular Silica Gels - R60 Silica (20-45 µm)

    SiliaFlash® Irregular Silica Gels - R60 Silica (20-45 µm)

    SiliCycle offers a wide selection of silica gels with pore size of 60 Å including particle size distribution of 20-45 µm for high performance chromatography purposes.

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