Drug Development
SiliCycle designs, develops, and manufactures innovative products for world class pharmaceutical companies with gram to multi-tons production capabilities. For large scale purifications, our state-of-the-art facilities allow us to produce high quality chromatographic phases in large batches to supply the most demanding applications.
We are also producing large amount of metal scavengers for the selective removal of spent metal catalysts traces from active pharmaceutical ingredients (API). These ligands bound to silica gel, in bulk or in cartridge formats, are especially designed to remove metal traces down to single digit ppm levels fast and reproducibly. A simple filtration is then performed to get rid of the silica scavenger with the metals entrapped.
We are also producing high quality chromatographic phases for any separation project, large or small. We can supply large quantities of normal, reverse, and ion-exchange phases that will give you the best performance at a competitive price.
Our new line of SiliaCat® heterogeneous catalysts are also very valuable tools for scale-up and process. These catalysts are easy to use and very efficient. At the end of the reaction, a simple filtration removes the spent catalyst and leaves the reaction mixture free of any metal traces.
Furthermore, our technical experts are always there to assist you with any question or to guide you in any given application.
We are your number 1 metal removal solution provider, and your partner of choice for your synthesis, catalysis, analysis and all of your purification requirements.
We commit ourselves to offer you best quality products for price!
- Under a CDA, we will screen a customer’s metal contaminated reaction mixture against our SiliaMetS Metal scavengers to determine the best scavenger and the best conditions.
Custom Phase Synthesis:
- We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.
CONTACT US for more details
- Our team of dedicated specialist will answer your questions, no matter how technical they are.
Products of Interest:
- New SiliaBond® C18
- SiliaMetS® Metal Scavengers
- SiliaBond® Reagents
- SiliaCat® Heterogeneous Catalysts
- SiliaFlash® Irregular Silica Gels
- SiliaSep™ Flash Cartridges HP
- SiliaSep™ Accessories
- SiliaPrep™ SPE (scx-carbonate-NH2)
- SiliaPrep™ Well Plates
- SiliaPlates™ TLC Plates
- METTLER TOLEDO MiniBlock®
Applications:
- Scavenging Palladium Catalysts
- Scavenging Pd(Dppf)Cl2 Catalyst
- SiliaBond® Metal Scavenger: Compatible With RCM Reaction
- SiliaBond® (Bulk) & SiliaPrep™ (SPE) Scavenging Efficiency Comparison
- SiliaBond® Metal Scavenger: Easily Scalable
- Use Of SiliaBond® TMA Acetate
- TFA Removal Using SiliaPrep™ Carbonate
- Scavenging HOBt With SiliaBond® Carbonate
- TLC Troubleshooting: Switching To SiliaPlate™ TLC
- Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
- Reductive Amination - Use Of SiliaBond® Cyanoborohydride
- Friedel-Crafts Alkylation
- Use Of SiliaCat® TEMPO
- Use Of SiliaCat® DPP-Pd
- Use Of SiliaCat® S-Pd
Posters:
- SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
- SiliaBond Metal Scavengers: An Efficient Tool to Remove Metal Residues From Small to Large Scale APIs Synthesis
- Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
- SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates
- SiliaCat TEMPO: an Effective and Recyclable Oxidizing Catalyst
- SiliaCat S-Pd and SiliaCat DPP-Pd: Highly Reactive and Reusable Heterogeneous Silica-Based Palladium Catalysts
- Functionalized Silica Gels for Amide Coupling Reactions
- SiliaBond Carbonate: a Useful Reagent for Amide Synthesis
- New SiliaBond Coupling Reagents to Expedite Amide and Ester Synthesis
- SiliaSep HP Flash Cartridges: New High Performance Separation Tools
- Efficient Peptide-Protein Purification by Flash Chromatography Based on Silica gel - Effect of Pore Size and Hydrophobicity in Reversed Phase Chromatography
21 Item(s)
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SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Silica
SiliaPrep Silica is the most polar sorbent presenting a slightly acidic character used to extract various compounds from non-polar solvents using hydrogen bonding. Efficient sorbent for the separation of analytes with similar structures and for removing the baseline noise from organic samples.
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges C8
SiliaPrep C8 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds. The SiliaPrep C8 nec is more selective than C18 phase for compounds such as heavy PAH, vitamins D and oil & greasy compounds.
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SiliaPrep™ SPE Cartridges C8 nec
SiliaPrep C8 nec is a non-polar sorbent and presents a moderate hydrophobicity. This phase is used to extract extremely non-polar compounds. The SiliaPrep C8 nec is more selective than C18 phase for compounds such as heavy PAH, vitamins D and oil & greasy compounds.
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SiliaPrep™ SPE Cartridges C18 nec (23%)
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids and various compounds from water, foods & beverages. Presence of free silanols allows secondary interactions for the extraction of basic compounds.
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SiliaPrep™ SPE Cartridges C18 (17%)
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids.
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SiliaPrep™ SPE Cartridges C18 nec (17%)
SiliaPrep C18 nec is a non-polar sorbent similar to SiliaPrep C18 but presents higher retention and polar selectivity for basic compounds. Unreacted surface OH's can be used for soft condition of catch and release purification of glucoronides for example.
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SiliaPrep™ SPE Cartridges C18 (11%)
SiliaPrep C18 (11%) is a non-polar sorbent used to elute very large hydrophobic molecules that are too strongly retained on higher carbon loading.
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SiliaPrep™ SPE Cartridges C18 nec (11%)
SiliaPrep C18 (11%) is a non-polar sorbent used to elute very large hydrophobic molecules that are too strongly retained on higher carbon loading. Use this less retentive phase for a rapid release of hydrophobic compounds using weaker organic solvents at lower volumes.
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SiliaPrep™ SPE Cartridges TMA Acetate nec
SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.
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SiliaPrep™ SPE Cartridges Tosic Acid (SCX)
SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)
SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Carbodiimide (DCC)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
21 Item(s)
List Grid
- Application Fields
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- Forensic (5)
- Metal to Remove
- Family / Formats
- Phases
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- Amine (2)
- C18 (5)
- C8 (2)
- Carbodiimide (DCC) (1)
- Carbonate (1)
- Diamine (2)
- Dichlorotriazine (DCT) (1)
- Propylsulfonic Acid (SCX-2) (2)
- Silica (1)
- TMA Acetate (1)
- Tosic Acid (SCX) (2)
- Triamine (1)
- Pore Size
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- 60 Å (21)
- Endcapping
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- Endcapped (21)
- Non-endcapped (6)
- Cartridges Volume
- Particle Size
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