Drug Development
SiliCycle designs, develops, and manufactures innovative products for world class pharmaceutical companies with gram to multi-tons production capabilities. For large scale purifications, our state-of-the-art facilities allow us to produce high quality chromatographic phases in large batches to supply the most demanding applications.
We are also producing large amount of metal scavengers for the selective removal of spent metal catalysts traces from active pharmaceutical ingredients (API). These ligands bound to silica gel, in bulk or in cartridge formats, are especially designed to remove metal traces down to single digit ppm levels fast and reproducibly. A simple filtration is then performed to get rid of the silica scavenger with the metals entrapped.
We are also producing high quality chromatographic phases for any separation project, large or small. We can supply large quantities of normal, reverse, and ion-exchange phases that will give you the best performance at a competitive price.
Our new line of SiliaCat® heterogeneous catalysts are also very valuable tools for scale-up and process. These catalysts are easy to use and very efficient. At the end of the reaction, a simple filtration removes the spent catalyst and leaves the reaction mixture free of any metal traces.
Furthermore, our technical experts are always there to assist you with any question or to guide you in any given application.
We are your number 1 metal removal solution provider, and your partner of choice for your synthesis, catalysis, analysis and all of your purification requirements.
We commit ourselves to offer you best quality products for price!
- Under a CDA, we will screen a customer’s metal contaminated reaction mixture against our SiliaMetS Metal scavengers to determine the best scavenger and the best conditions.
Custom Phase Synthesis:
- We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.
CONTACT US for more details
- Our team of dedicated specialist will answer your questions, no matter how technical they are.
Products of Interest:
- New SiliaBond® C18
- SiliaMetS® Metal Scavengers
- SiliaBond® Reagents
- SiliaCat® Heterogeneous Catalysts
- SiliaFlash® Irregular Silica Gels
- SiliaSep™ Flash Cartridges HP
- SiliaSep™ Accessories
- SiliaPrep™ SPE (scx-carbonate-NH2)
- SiliaPrep™ Well Plates
- SiliaPlates™ TLC Plates
- METTLER TOLEDO MiniBlock®
Applications:
- Scavenging Palladium Catalysts
- Scavenging Pd(Dppf)Cl2 Catalyst
- SiliaBond® Metal Scavenger: Compatible With RCM Reaction
- SiliaBond® (Bulk) & SiliaPrep™ (SPE) Scavenging Efficiency Comparison
- SiliaBond® Metal Scavenger: Easily Scalable
- Use Of SiliaBond® TMA Acetate
- TFA Removal Using SiliaPrep™ Carbonate
- Scavenging HOBt With SiliaBond® Carbonate
- TLC Troubleshooting: Switching To SiliaPlate™ TLC
- Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
- Reductive Amination - Use Of SiliaBond® Cyanoborohydride
- Friedel-Crafts Alkylation
- Use Of SiliaCat® TEMPO
- Use Of SiliaCat® DPP-Pd
- Use Of SiliaCat® S-Pd
Posters:
- SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
- SiliaBond Metal Scavengers: An Efficient Tool to Remove Metal Residues From Small to Large Scale APIs Synthesis
- Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
- SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates
- SiliaCat TEMPO: an Effective and Recyclable Oxidizing Catalyst
- SiliaCat S-Pd and SiliaCat DPP-Pd: Highly Reactive and Reusable Heterogeneous Silica-Based Palladium Catalysts
- Functionalized Silica Gels for Amide Coupling Reactions
- SiliaBond Carbonate: a Useful Reagent for Amide Synthesis
- New SiliaBond Coupling Reagents to Expedite Amide and Ester Synthesis
- SiliaSep HP Flash Cartridges: New High Performance Separation Tools
- Efficient Peptide-Protein Purification by Flash Chromatography Based on Silica gel - Effect of Pore Size and Hydrophobicity in Reversed Phase Chromatography
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SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)
SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Carbodiimide (DCC)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaSphere™ Spherical Silica Gels C18 mono
We offer the SiliaSphere™ C18 as a standard functionalized product in various pore sizes between 60 to 1000Å and in a wide range of particle size (1.8 to 15 µm).
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SiliaSphere™ Spherical Silica Gels Preparative Chromatography PC Silica
SiliCycle offers a wide selection of spherical silica gels with different pore sizes between 70 to 1000Å with particle size distribution ranging from 20-45 µm to 75-200 µm for chromatography purposes as a replacement of irregular silicas.
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SiliaSep™ Flash Cartridges Cyano
Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.
SiliaSep flash cyano cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Amine
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
SiliaSep flash amine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges TMA Chloride (SAX)
Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by catch and release process.
SiliaSep flash TMA Chloride cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges TMA Acetate nec
Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by catch and release process.
SiliaSep flash TMA Acetate cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Tosic Acid (SCX)
Packed with a strong cation exchanger, they can be used to fully retain basic compounds for clean-up or to isolate them by catch and release process.
SiliaSep flash propylsulfonic acid cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Diol
Good alternative for difficult separation of low to medium polarity samples. Offer a better retention time compared to normal phase.
SiliaSep flash diol cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges - Open Top (OT) Silica
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
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SiliaSep™ Flash Cartridges - Open Top (OT) C18 nec
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Open Top (OT) C18
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Open Top (OT) Cyano
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.
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SiliaSep™ Flash Cartridges - Open Top (OT) Amine
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Open Top (OT) Diol
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Good alternative for difficult separation of low to medium polarity samples. Offer a better retention time compared to normal phase.
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SiliaSep™ Flash Cartridges - Open Top (OT) Propylsulfonic Acid (SCX-2)
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Open Top (OT) Tosic Acid (SCX)
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Packed with a strong cation exchanger, they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Open Top (OT) TMA Chloride nec (SAX)
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Open Top (OT) TMA Acetate nec
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Packed with a strong anion exchanger, they can be used to fully retain acidic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Open Top (OT) Carbonate
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
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SiliaSep™ Flash Cartridges - Open Top (OT) Thiol
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
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SiliaSep™ Flash Cartridges - Open Top (OT) Fluorochrom
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Indicated for the purification of fluorous compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Silica
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) C18 nec
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) C18
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Diol
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Good alternative for difficult separation of low to medium polarity samples. Offer a better retention time compared to normal phase.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Propylsulfonic Acid (SCX-2)
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Silica
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) C18 nec
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Cyano
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Amine
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) SCX
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Packed with a strong cation exchanger, they can be used to fully retain basic compounds for clean-up or to isolate them by catch and release process.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Diol
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Good alternative for difficult separation of low to medium polarity samples. Offer a better retention time compared to normal phase.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) SCX-2
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by catch and release process.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Fluorochrom
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Indicated for the purification of fluorous compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Silica
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges C18 nec (23%)
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges C18 (17%)
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Amino
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Cyano
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges Diol
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
- Application Fields
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- Forensic (5)
- Metal to Remove
- Family / Formats
- Phases
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- Amine (10)
- Amino (1)
- C18 (20)
- C8 (4)
- Carbodiimide (DCC) (3)
- Carbonate (4)
- Carboxylic Acid (WCX) (2)
- Cyano (5)
- Cyanoborohydride (2)
- Cysteine (3)
- Diamine (5)
- Dichlorotriazine (DCT) (3)
- Diethylamine (1)
- Dimercaptotriazine (DMT) (4)
- Dimethylamine (1)
- Diol (5)
- Diphenylphosphine (1)
- DMAP (2)
- DPP-Pd (1)
- Ethyl Carbodiimide (EDC) (2)
- Fluorochrom (2)
- HOBt (1)
- Imidazole (2)
- Morpholine (1)
- Piperazine (1)
- Potassium Permanganate (2)
- Propylsulfonic Acid (SCX-2) (8)
- Pyridine (1)
- Pyridinium Chlorochromate (PCC) (2)
- Pyridinium Dichromate (PDC) (2)
- S-Pd (1)
- SCX (1)
- SCX-2 (1)
- Silica (32)
- TAAcOH (5)
- TAAcONa (4)
- TBD (2)
- TEMPO (2)
- Thiol (5)
- Thiourea (4)
- TMA Acetate (4)
- TMA Chloride (SAX) (2)
- Tosic Acid (SCX) (7)
- Tosyl Hydrazine (1)
- Triamine (5)
- Pore Size
- Endcapping
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- Endcapped (136)
- Non-endcapped (25)
- Cartridges Volume
- Bed Weight
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- 50 mg (20)
- 100 mg (21)
- 200 mg (25)
- 500 mg (25)
- 1 g (26)
- 2 g (31)
- 4 g (26)
- 5 g (38)
- 8 g (8)
- 9 g (7)
- 10 g (14)
- 12 g (18)
- 15 g (13)
- 20 g (13)
- 25 g (34)
- 40 g (26)
- 45 g (7)
- 50 g (13)
- 65 g (5)
- 70 g (13)
- 80 g (18)
- 90 g (15)
- 100 g (13)
- 120 g (18)
- 135 g (7)
- 200 g (7)
- 220 g (18)
- 270 g (2)
- 330 g (18)
- 350 g (7)
- 400 g (7)
- 800 g (10)
- 1600 g (3)
- Particle Size
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- 3 µm (1)
- 5 µm (1)
- 10 µm (1)
- 15 µm (1)
- 0-20 µm / 625->2,500 mesh (1)
- 10-30 µm / 475-1,250 mesh (1)
- 5-20 µm / 625-2,500 mesh (1)
- 15-25 µm / 325-625 mesh (2)
- 15-35 µm / 400-940 mesh (2)
- 15-40 µm / 400-1,250 mesh (1)
- 20-45 µm / 325-625 mesh (2)
- 40-63 µm / 230-400 mesh (111)
- 40-75 µm / 200-400 mesh (1)
- 60-120 µm / 70-230 mesh (2)
- 60-200 µm / 70-230 mesh (3)
- 63-250 µm / 60-230 mesh (3)
- 75-200 µm / 60-200 mesh (1)
- 120-200 µm / 70-120 mesh (2)
- 200-500 µm / 35-75 mesh (4)
- 250-500 µm / 35-60 mesh (1)
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