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Drug Discovery

SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.

Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.

We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.

We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

    • CONTACT US for more details

Extensive Technical Support:

  • Our team of dedicated specialist will answer your questions, no matter how technical they are.

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  1. SiliaMetS® Metal Scavenger Kit

    SiliaMetS® Metal Scavenger Kit

    Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea
  2. SiliaMetS® Triamine

    SiliaMetS® Triamine

    SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.

  3. SiliaMetS® Diamine

    SiliaMetS® Diamine

    SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.

  4. SiliaMetS® Thiol

    SiliaMetS® Thiol

    SiliaMetS® Thiol (Si-Thiol) is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions. It has been used in pharmaceutical processes up to the pilot plant scale. It is our most versatile metal scavenger and is the preferred metal scavenger for Pd(II), Cu, Ag, and Hg.

  5. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  6. SiliaBond® TBD

    SiliaBond® TBD

    SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.

  7. SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).

  8. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  9. SiliaMetS® Thiourea

    SiliaMetS® Thiourea

    SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.

  10. SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.

    TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.

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Filter By
Metal to Remove
Silver (Ag)
  1. Preferred Scavengers (4)
  2. Scavenge (3)
Calcium (Ca)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Cadmium (Cd)
  1. Preferred Scavengers (13)
  2. Scavenge (7)
Cobalt (Co)
  1. Preferred Scavengers (4)
  2. Scavenge (17)
Chromium (Cr)
  1. Preferred Scavengers (14)
  2. Scavenge (9)
Cesium (Cs)
  1. Preferred Scavengers (3)
  2. Scavenge (5)
Copper (Cu)
  1. Preferred Scavengers (4)
  2. Scavenge (26)
Iron (Fe)
  1. Preferred Scavengers (6)
  2. Scavenge (23)
Mercury (Hg)
  1. Preferred Scavengers (4)
  2. Scavenge (11)
Iridium (Ir)
  1. Preferred Scavengers (8)
  2. Scavenge (4)
Lanthanum (La)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Lithium (Li)
  1. Preferred Scavengers (3)
Magnesium (Mg)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Nickel (Ni)
  1. Preferred Scavengers (9)
  2. Scavenge (8)
Osmium (Os)
  1. Preferred Scavengers (15)
  2. Scavenge (4)
Lead (Pb)
  1. Preferred Scavengers (3)
  2. Scavenge (15)
Palladium (Pd-2+)
  1. Preferred Scavengers (17)
  2. Scavenge (16)
Palladium (Pd-0)
  1. Preferred Scavengers (17)
  2. Scavenge (9)
Platinum (Pt)
  1. Preferred Scavengers (17)
  2. Scavenge (2)
Rhodium (Rh-1+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-2+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-3+)
  1. Preferred Scavengers (6)
  2. Scavenge (7)
Ruthenium (Ru-2+)
  1. Preferred Scavengers (5)
  2. Scavenge (14)
Scandium (Sc)
  1. Preferred Scavengers (8)
  2. Scavenge (10)
Tin (Sn)
  1. Preferred Scavengers (5)
  2. Scavenge (10)
Tungsten (W)
  1. Preferred Scavengers (2)
  2. Scavenge (13)
Zinc (Zn)
  1. Preferred Scavengers (1)
  2. Scavenge (22)
Scavenge Others
  1. Scavenge (1)
Family / Formats
  1. Micro Tube (9)
  2. SiliaBond® (Functionalized Silicas) (36)
  3. SiliaCat® (Heterogeneous Catalysts) (3)
  4. SiliaMetS® (Metal Scavengers) (8)
  5. SiliaPlate™ (TLC Plates) (12)
  6. SiliaSep™ (Flash Cartridges) (54)
  7. SiliaPrep™ (SPE Cartridges) (44)
Phases
  1. Aluminum Chloride (1)
  2. Amine (10)
  3. Amino (1)
  4. C18 (23)
  5. C2 (1)
  6. C8 (4)
  7. Carbodiimide (DCC) (3)
  8. Carbonate (4)
  9. CleanDRUG (1)
  10. CleanENVI (1)
  11. CN (1)
  12. Cyano (5)
  13. Cyanoborohydride (2)
  14. Cysteine (4)
  15. Diamine (5)
  16. Dichlorotriazine (DCT) (2)
  17. Dimercaptotriazine (DMT) (5)
  18. Diol (6)
  19. DMAP (2)
  20. DPP-Pd (1)
  21. Ethyl Carbodiimide (EDC) (2)
  22. Fluorochrom (4)
  23. HOBt (1)
  24. Imidazole (3)
  25. NH2 (1)
  26. Pentafluorophenyl (2)
  27. Potassium Permanganate (2)
  28. Propylsulfonic Acid (SCX-2) (9)
  29. Pyridinium Chlorochromate (PCC) (2)
  30. Pyridinium Dichromate (PDC) (2)
  31. S-Pd (1)
  32. SCX (1)
  33. SCX-2 (1)
  34. Silica (13)
  35. Silver Nitrate (AgNO3) (1)
  36. TAAcOH (5)
  37. TAAcONa (5)
  38. TBD (1)
  39. TEMPO (2)
  40. Thiol (6)
  41. Thiourea (5)
  42. TMA Acetate (5)
  43. TMA Chloride (SAX) (2)
  44. Tosic Acid (SCX) (8)
  45. Triamine (5)
  46. Tridecafluoro (2)
Pore Size
  1. 60 Å (134)
  2. 25-70 Å (3)
Endcapping
  1. Endcapped (133)
  2. Non-endcapped (36)
Cartridges Volume
  1. 1 500 mL (1)
  2. 123 mL (1)
  3. 17 mL (1)
  4. 190 mL (1)
  5. 2 900 mL (1)
  6. 306 mL (1)
  7. 31 mL (1)
  8. 4.9 mL (1)
  9. 441 mL (1)
  10. 47 mL (1)
  11. 1 mL (23)
  12. 2 mL (25)
  13. 3 mL (27)
  14. 6 mL (28)
  15. 10 mL (6)
  16. 12 mL (28)
  17. 25 mL (30)
  18. 60 mL (3)
  19. 70 mL (13)
  20. 150 mL (19)
  21. 276 mL (13)
  22. 700 mL (3)
Bed Weight
  1. 50 mg (47)
  2. 100 mg (39)
  3. 200 mg (27)
  4. 500 mg (27)
  5. 1 g (28)
  6. 2 g (33)
  7. 4 g (27)
  8. 5 g (40)
  9. 8 g (8)
  10. 9 g (7)
  11. 10 g (14)
  12. 12 g (19)
  13. 15 g (13)
  14. 20 g (13)
  15. 25 g (35)
  16. 40 g (27)
  17. 45 g (7)
  18. 50 g (13)
  19. 65 g (6)
  20. 70 g (13)
  21. 80 g (19)
  22. 90 g (15)
  23. 100 g (13)
  24. 120 g (19)
  25. 135 g (7)
  26. 200 g (7)
  27. 220 g (18)
  28. 270 g (3)
  29. 330 g (18)
  30. 350 g (7)
  31. 400 g (7)
  32. 800 g (10)
  33. 1600 g (3)
Particle Size
  1. 15-40 µm (1)
  2. 40-63 µm (133)
  3. 63-250 µm (3)

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Testimonials

“The high quality nature of the columns and plates from SiliCycle has allowed us to achieve a level of reproducibility with our compound libraries that would be unheard of with any other production line.”
[Steven Marois, Boston University CMLD]

“Several of my teams have successfully employed SiliCycle resins to scavenge metals from APIs. The fact that these scavengers work so well allow us to employ Pd-catalyzed cross couplings as final steps in API synthetic sequences confidently, knowing that we will likely be able to reduce transition metal contamination to acceptable levels in the final drug substance.”
[Akin Davulcu, Bristol-Myers Squibb]

“BioVectra has been able to leverage its large scale chromatography capability with the technical and product capability of the SiliCyle team into the manufacturing of important oncology active pharma ingredients. We have been associated with SiliCycle since 1998, and look forward to working together on many new projects in the future.”
[Dale Zajicek, BioVectra]

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© 2012 SiliCycle.

Worldwide Headquarters SiliCycle Inc., 2500, Parc-Technologique Blvd, Quebec City (Quebec) G1P 4S6, CANADA
Phone: 1 418.874.0054 Toll Free: 1 877.745.4292 (North America only)
Fax: 1 418.874.0355 E-mail: info@silicycle.com
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