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Drug Discovery

SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.

Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.

We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.

We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

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  1. SiliaPlate™ TLC Plates - Aluminum (Al) Silica

    SiliaPlate™ TLC Plates - Aluminum (Al) Silica

    Standard Normal Phase, Analytical SiliaPlateTM made with SiliaFlash® silica gel is available on Aluminum backing.
  2. SiliaPlate™ TLC Plates - Aluminum (Al) C18 - TLA-R30411B-303

    SiliaPlate™ TLC Plates - Aluminum (Al) C18 - TLA-R30411B-303

    Standard Reverse Phase, Analytical SiliaPlateTM made with C18 functionalized SiliaFlash® silica gel is available on Aluminum backing.

  3. SiliaPlate™ TLC Plates - Glass (G) Silica

    SiliaPlate™ TLC Plates - Glass (G) Silica

    Standard normal phase Analytical SiliaPlate™ made with SiliaFlash® silica gel are available on glass backing. Different sizes available.

  4. SiliaPrep™ SPE Cartridges Silica

    SiliaPrep™ SPE Cartridges Silica

    SiliaPrep Silica is the most polar sorbent presenting a slightly acidic character used to extract various compounds from non-polar solvents using hydrogen bonding. Efficient sorbent for the separation of analytes with similar structures and for removing the baseline noise from organic samples.

  5. SiliaSep™ Flash Cartridges Silica

    SiliaSep™ Flash Cartridges Silica

    SiliaSep flash cartridges offer a superior alternative to the other cartridges available on the market as they present the following characteristics:

  6. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  7. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  8. SiliaPrep™ SPE Cartridges C18 nec (23%)

    SiliaPrep™ SPE Cartridges C18 nec (23%)

    SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids and various compounds from water, foods & beverages. Presence of free silanols allows secondary interactions for the extraction of basic compounds.

  9. SiliaPrep™ SPE Cartridges C18 (17%)

    SiliaPrep™ SPE Cartridges C18 (17%)

    SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids.

  10. SiliaPrep™ SPE Cartridges C18 nec (17%)

    SiliaPrep™ SPE Cartridges C18 nec (17%)

    SiliaPrep C18 nec is a non-polar sorbent similar to SiliaPrep C18 but presents higher retention and polar selectivity for basic compounds. Unreacted surface OH's can be used for soft condition of catch and release purification of glucoronides for example.

  11. SiliaPrep™ SPE Cartridges Pentafluoprophenyl

    SiliaPrep™ SPE Cartridges Pentafluoprophenyl

    SiliaPrep Pentafluorophenyl is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones. The electron density presents fluorinated aromatic ring which affords an enhancement in the retention of conjugated and aromatic ring-containing due to the desirable pi-pi interactions. Excellent alternative of the C18 when the C18 presents a selectivity problem.

  12. SiliaPrep™ SPE Cartridges Fluorochrom

    SiliaPrep™ SPE Cartridges Fluorochrom

    SiliaPrep Fluorochrom is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.

  13. SiliaPrep™ SPE Cartridges Tridecafluoro

    SiliaPrep™ SPE Cartridges Tridecafluoro

    SiliaPrep Tridecafluoro is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.

  14. SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.

  15. SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  16. SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  17. SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  18. SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  19. SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  20. SiliaPrep™ SPE Cartridges Carbodiimide (DCC)

    SiliaPrep™ SPE Cartridges Carbodiimide (DCC)

    SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.

  21. SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)

    SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)

    SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.

  22. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  23. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  24. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  25. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  26. SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  27. SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  28. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  29. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  30. SiliaPrep™ SPE Cartridges C18

    SiliaPrep™ SPE Cartridges C18

    SiliaPrep Certified C18 phase has been optimized for isolation of acidic, neutral and basic compounds from aqueous solution.

  31. SiliaPrep™ SPE Cartridges CleanDRUG

    SiliaPrep™ SPE Cartridges CleanDRUG

    SiliaPrepCleanDRUG phase has been optimized for drugs of abuse applications

  32. SiliaPrep™ SPE Cartridges CleanENVI

    SiliaPrep™ SPE Cartridges CleanENVI

    SiliaPrepCleanENVI phase has been optimized for typical environment samples according to the EPA regulations.

  33. SiliaPrep™ 96 Well Plates Silica

    SiliaPrep™ 96 Well Plates Silica


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  34. SiliaPrep™ 96 Well Plates (23%) C18 nec

    SiliaPrep™ 96 Well Plates (23%) C18 nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  35. SiliaPrep™ 96 Well Plates C18

    SiliaPrep™ 96 Well Plates C18


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  36. SiliaPrep™ 96 Well Plates C18 mono nec

    SiliaPrep™ 96 Well Plates C18 mono nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  37. SiliaPrep™ 96 Well Plates C8

    SiliaPrep™ 96 Well Plates C8


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  38. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  39. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  40. SiliaPrep™ 96 Well Plates Carbonate

    SiliaPrep™ 96 Well Plates Carbonate


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  41. SiliaPrep™ 96 Well Plates Pentafluorophenyl

    SiliaPrep™ 96 Well Plates Pentafluorophenyl


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  42. SiliaPrep™ 96 Well Plates Fluorochrom

    SiliaPrep™ 96 Well Plates Fluorochrom


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  43. SiliaPrep™ 96 Well Plates TMA Acetate nec

    SiliaPrep™ 96 Well Plates TMA Acetate nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  44. SiliaPrep™ 96 Well Plates Tosic Acid (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  45. SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  46. SiliaPrep™ 96 Well Plates Tridecafluoro

    SiliaPrep™ 96 Well Plates Tridecafluoro


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  47. SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)

    SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  48. SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)

    SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  49. SiliaSep™ Flash Cartridges C18 nec

    SiliaSep™ Flash Cartridges C18 nec

    Indicated for the purification of medium to high polarity compounds.  They provide reproducible purification without the complexity and cost of preparative HPLC.

    SiliaSep flash C18 cartridges offer a superior alternative to the other cartridges available on the market.

  50. SiliaSep™ Flash Cartridges C18

    SiliaSep™ Flash Cartridges C18

    Indicated for the purification of medium to high polarity compounds.  They provide reproducible purification without the complexity and cost of preparative HPLC.

    SiliaSep flash C18 cartridges offer a superior alternative to the other cartridges available on the market.

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Application Fields
  1. Environment (1)
  2. Food & Beverage (1)
  3. Forensic (5)
Metal to Remove
Silver (Ag)
  1. Preferred Scavengers (4)
  2. Scavenge (3)
Calcium (Ca)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Cadmium (Cd)
  1. Preferred Scavengers (13)
  2. Scavenge (7)
Cobalt (Co)
  1. Preferred Scavengers (4)
  2. Scavenge (17)
Chromium (Cr)
  1. Preferred Scavengers (14)
  2. Scavenge (9)
Cesium (Cs)
  1. Preferred Scavengers (3)
  2. Scavenge (5)
Copper (Cu)
  1. Preferred Scavengers (4)
  2. Scavenge (26)
Iron (Fe)
  1. Preferred Scavengers (6)
  2. Scavenge (23)
Mercury (Hg)
  1. Preferred Scavengers (4)
  2. Scavenge (11)
Iridium (Ir)
  1. Preferred Scavengers (8)
  2. Scavenge (4)
Lanthanum (La)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Lithium (Li)
  1. Preferred Scavengers (3)
Magnesium (Mg)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Nickel (Ni)
  1. Preferred Scavengers (9)
  2. Scavenge (8)
Osmium (Os)
  1. Preferred Scavengers (15)
  2. Scavenge (4)
Lead (Pb)
  1. Preferred Scavengers (3)
  2. Scavenge (15)
Palladium (Pd-2+)
  1. Preferred Scavengers (17)
  2. Scavenge (16)
Palladium (Pd-0)
  1. Preferred Scavengers (17)
  2. Scavenge (9)
Platinum (Pt)
  1. Preferred Scavengers (17)
  2. Scavenge (2)
Rhodium (Rh-1+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-2+)
  1. Preferred Scavengers (10)
  2. Scavenge (16)
Rhodium (Rh-3+)
  1. Preferred Scavengers (6)
  2. Scavenge (7)
Ruthenium (Ru-2+)
  1. Preferred Scavengers (5)
  2. Scavenge (14)
Scandium (Sc)
  1. Preferred Scavengers (8)
  2. Scavenge (10)
Tin (Sn)
  1. Preferred Scavengers (5)
  2. Scavenge (10)
Tungsten (W)
  1. Preferred Scavengers (2)
  2. Scavenge (13)
Zinc (Zn)
  1. Preferred Scavengers (1)
  2. Scavenge (22)
Scavenge Others
  1. Scavenge (1)
Family / Formats
  1. SiliaBond® (Functionalized Silicas) (29)
  2. SiliaCat® (Heterogeneous Catalysts) (3)
  3. SiliaMetS® (Metal Scavengers) (8)
  4. SiliaPlate™ (TLC Plates) (12)
  5. SiliaSep™ (Flash Cartridges) (53)
  6. SiliaPrep™ (SPE Cartridges) (44)
Phases
  1. Aluminum Chloride (1)
  2. Amine (10)
  3. Amino (1)
  4. C18 (23)
  5. C2 (1)
  6. C8 (4)
  7. Carbodiimide (DCC) (3)
  8. Carbonate (4)
  9. CleanDRUG (1)
  10. CleanENVI (1)
  11. CN (1)
  12. Cyano (5)
  13. Cyanoborohydride (2)
  14. Cysteine (3)
  15. Diamine (4)
  16. Dichlorotriazine (DCT) (2)
  17. Dimercaptotriazine (DMT) (4)
  18. Diol (6)
  19. DMAP (2)
  20. DPP-Pd (1)
  21. Ethyl Carbodiimide (EDC) (2)
  22. Fluorochrom (4)
  23. HOBt (1)
  24. Imidazole (2)
  25. NH2 (1)
  26. Pentafluorophenyl (2)
  27. Potassium Permanganate (2)
  28. Propylsulfonic Acid (SCX-2) (9)
  29. Pyridinium Chlorochromate (PCC) (2)
  30. Pyridinium Dichromate (PDC) (2)
  31. S-Pd (1)
  32. SCX (1)
  33. SCX-2 (1)
  34. Silica (13)
  35. Silver Nitrate (AgNO3) (1)
  36. TAAcOH (4)
  37. TAAcONa (4)
  38. TBD (1)
  39. TEMPO (2)
  40. Thiol (5)
  41. Thiourea (4)
  42. TMA Acetate (5)
  43. TMA Chloride (SAX) (2)
  44. Tosic Acid (SCX) (8)
  45. Triamine (4)
  46. Tridecafluoro (2)
Pore Size
  1. 60 Å (124)
  2. 25-70 Å (3)
Endcapping
  1. Endcapped (139)
  2. Non-endcapped (27)
Cartridges Volume
  1. 1 500 mL (1)
  2. 123 mL (1)
  3. 17 mL (1)
  4. 190 mL (1)
  5. 2 900 mL (1)
  6. 306 mL (1)
  7. 31 mL (1)
  8. 4.9 mL (1)
  9. 441 mL (1)
  10. 47 mL (1)
  11. 1 mL (23)
  12. 2 mL (16)
  13. 3 mL (27)
  14. 6 mL (28)
  15. 10 mL (6)
  16. 12 mL (28)
  17. 25 mL (30)
  18. 60 mL (3)
  19. 70 mL (13)
  20. 150 mL (18)
  21. 276 mL (13)
  22. 700 mL (2)
Bed Weight
  1. 50 mg (38)
  2. 100 mg (39)
  3. 200 mg (27)
  4. 500 mg (27)
  5. 1 g (28)
  6. 2 g (33)
  7. 4 g (26)
  8. 5 g (40)
  9. 8 g (8)
  10. 9 g (7)
  11. 10 g (14)
  12. 12 g (18)
  13. 15 g (13)
  14. 20 g (13)
  15. 25 g (34)
  16. 40 g (26)
  17. 45 g (7)
  18. 50 g (13)
  19. 65 g (5)
  20. 70 g (13)
  21. 80 g (18)
  22. 90 g (15)
  23. 100 g (13)
  24. 120 g (18)
  25. 135 g (7)
  26. 200 g (7)
  27. 220 g (18)
  28. 270 g (2)
  29. 330 g (18)
  30. 350 g (7)
  31. 400 g (7)
  32. 800 g (10)
  33. 1600 g (3)
Particle Size
  1. 40-63 µm / 230-400 mesh (124)
  2. 63-250 µm / 60-230 mesh (3)

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