Drug Discovery
SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.
Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.
We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.
We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!
- Under a CDA, we will screen a customer’s metal contaminated reaction mixture against our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.
Custom Phase Synthesis:
- We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.
CONTACT US for more details
- Our team of dedicated specialist will answer your questions, no matter how technical they are.
Products of Interest:
- New SiliaBond® C18
- SiliaMetS® Metal Scavengers
- SiliaBond® Reagents
- SiliaCat® Heterogeneous Catalysts
- SiliaFlash® Irregular Silica Gels
- SiliaSep™ Flash Cartridges HP
- SiliaSep™ Accessories
- SiliaPrep™ SPE (scx-carbonate-NH2)
- SiliaPrep™ Well Plates
- SiliaPlates™ TLC Plates
- METTLER TOLEDO MiniBlock®
Applications:
- Scavenging Palladium Catalysts
- Scavenging Pd(Dppf)Cl2 Catalyst
- SiliaBond® Metal Scavenger: Compatible With RCM Reaction
- SiliaBond® (Bulk) & SiliaPrep™ (SPE) Scavenging Efficiency Comparison
- SiliaBond® Metal Scavenger: Easily Scalable
- Use Of SiliaBond® TMA Acetate
- TFA Removal Using SiliaPrep™ Carbonate
- Scavenging HOBt With SiliaBond® Carbonate
- TLC Troubleshooting: Switching To SiliaPlate™ TLC
- Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
- Reductive Amination - Use Of SiliaBond® Cyanoborohydride
- Friedel-Crafts Alkylation
- Use Of SiliaCat® TEMPO
- Use Of SiliaCat® DPP-Pd
- Use Of SiliaCat® S-Pd
Posters:
- SiliaBond Metal Scavengers: An Efficient Tool to Remove Metal Residues From Small to Large Scale APIs Synthesis
- SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
- Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
- SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates
- SiliaCat TEMPO: an Effective and Recyclable Oxidizing Catalyst
- SiliaCat S-Pd and SiliaCat DPP-Pd: Highly Reactive and Reusable Heterogeneous Silica-Based Palladium Catalysts
- Functionalized Silica Gels for Amide Coupling Reactions
- SiliaBond Carbonate: a Useful Reagent for Amide Synthesis
- New SiliaBond Coupling Reagents to Expedite Amide and Ester Synthesis
- SiliaSep HP Flash Cartridges: New High Performance Separation Tools
- Efficient Peptide-Protein Purification by Flash Chromatography Based on Silica gel - Effect of Pore Size and Hydrophobicity in Reversed Phase Chromatography
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SiliaBond® Propylsulfonic Acid (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Propylsulfonic Acid nec (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaSep™ Flash Cartridges Propylsulfonic Acid (SCX-2)
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by catch and release process.
SiliaSep flash propylsulfonic acid cartridges offer a superior alternative to the other cartridges available on the market..
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SiliaSep™ Flash Cartridges - Open Top (OT) Propylsulfonic Acid (SCX-2)
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Propylsulfonic Acid (SCX-2)
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
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