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Drug Discovery

SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.

Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.

We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.

We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

    • CONTACT US for more details

Extensive Technical Support:

  • Our team of dedicated specialist will answer your questions, no matter how technical they are.

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  1. SiliaMetS® Thiol

    SiliaMetS® Thiol

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    SiliaMetS® Thiol (Si-Thiol) is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions. It has been used in pharmaceutical processes up to the pilot plant scale. It is our most versatile metal scavenger and is the preferred metal scavenger for Pd(II), Cu, Ag, and Hg.

  2. SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).

  3. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  4. SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS® DMT (Si-DMT) is the silica bound equivalent of 2,4,6-trimercaptotriazine (trithiocyanuric acid). It is a versatile metal scavenger for a variety of metals including Cd, Co, Ni, Pd, Pt, Rh, and Ru under a wide range of conditions and the preferred metal scavenger for ruthenium catalysts.

    TMT has been reported to efficiently remove palladium and heavy metals by precipitation. Unfortunately, its solubility in organic solvents causes problem. SiliaMetS DMT solves this issue and almost all solvents can now be used.

  5. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  6. SiliaMetS® Cysteine

    SiliaMetS® Cysteine

    SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.

  7. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  8. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  9. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  10. SiliaSep™ Flash Cartridges Thiol

    SiliaSep™ Flash Cartridges Thiol

    SiliaSep flash thiol cartridges offer a superior alternative to the other cartridges available on the market.

  11. SiliaSep™ Flash Cartridges TAAcOH

    SiliaSep™ Flash Cartridges TAAcOH

    SiliaSep flash TAAcOH cartridges offer a superior alternative to the other cartridges available on the market.

  12. SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep flash TAAcONa cartridges offer a superior alternative to the other cartridges available on the market.

  13. SiliaSep™ Flash Cartridges Dimercaptotriazine (DMT)

    SiliaSep™ Flash Cartridges Dimercaptotriazine (DMT)

    SiliaSep flash DMT cartridges offer a superior alternative to the other cartridges available on the market.

  14. SiliaSep™ Flash Cartridges Cysteine

    SiliaSep™ Flash Cartridges Cysteine

    SiliaSep flash cysteine cartridges offer a superior alternative to the other cartridges available on the market .

  15. SiliaSep™ Flash Cartridges - Open Top (OT) Thiol

    SiliaSep™ Flash Cartridges - Open Top (OT) Thiol

    SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.

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  1. X Osmium (Os): Preferred Scavengers
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Metal to Remove
Silver (Ag)
  1. Preferred Scavengers (4)
Calcium (Ca)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Cadmium (Cd)
  1. Preferred Scavengers (6)
  2. Scavenge (3)
Cobalt (Co)
  1. Preferred Scavengers (3)
  2. Scavenge (3)
Chromium (Cr)
  1. Scavenge (8)
Cesium (Cs)
  1. Preferred Scavengers (3)
  2. Scavenge (4)
Copper (Cu)
  1. Preferred Scavengers (4)
  2. Scavenge (9)
Iron (Fe)
  1. Preferred Scavengers (6)
  2. Scavenge (5)
Mercury (Hg)
  1. Preferred Scavengers (4)
Iridium (Ir)
  1. Preferred Scavengers (8)
  2. Scavenge (4)
Lanthanum (La)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Lithium (Li)
  1. Preferred Scavengers (3)
Magnesium (Mg)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Nickel (Ni)
  1. Preferred Scavengers (9)
Lead (Pb)
  1. Scavenge (4)
Palladium (Pd-2+)
  1. Preferred Scavengers (7)
  2. Scavenge (8)
Palladium (Pd-0)
  1. Preferred Scavengers (7)
  2. Scavenge (8)
Platinum (Pt)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Rhodium (Rh-1+)
  1. Preferred Scavengers (3)
  2. Scavenge (12)
Rhodium (Rh-2+)
  1. Preferred Scavengers (3)
  2. Scavenge (12)
Rhodium (Rh-3+)
  1. Preferred Scavengers (6)
  2. Scavenge (4)
Ruthenium (Ru-2+)
  1. Preferred Scavengers (5)
  2. Scavenge (7)
Scandium (Sc)
  1. Preferred Scavengers (7)
  2. Scavenge (7)
Tin (Sn)
  1. Preferred Scavengers (5)
  2. Scavenge (6)
Tungsten (W)
  1. Preferred Scavengers (1)
Zinc (Zn)
  1. Preferred Scavengers (1)
  2. Scavenge (8)
Family / Formats
  1. SiliaMetS® (Metal Scavengers) (6)
  2. SiliaSep™ (Flash Cartridges) (6)
  3. SiliaPrep™ (SPE Cartridges) (3)
Phases
  1. Cysteine (2)
  2. Dimercaptotriazine (DMT) (3)
  3. Imidazole (1)
  4. TAAcOH (2)
  5. TAAcONa (3)
  6. Thiol (4)
Pore Size
  1. 60 Å (15)
Endcapping
  1. Endcapped (13)
  2. Non-endcapped (2)
Cartridges Volume
  1. 3 mL (2)
  2. 6 mL (3)
  3. 12 mL (3)
  4. 25 mL (3)
  5. 70 mL (1)
  6. 150 mL (1)
  7. 276 mL (1)
Bed Weight
  1. 200 mg (2)
  2. 500 mg (2)
  3. 1 g (3)
  4. 2 g (3)
  5. 4 g (5)
  6. 5 g (3)
  7. 10 g (1)
  8. 12 g (5)
  9. 15 g (1)
  10. 20 g (1)
  11. 25 g (6)
  12. 40 g (5)
  13. 50 g (1)
  14. 70 g (1)
  15. 80 g (5)
  16. 100 g (1)
  17. 120 g (5)
  18. 220 g (5)
  19. 330 g (5)
Particle Size
  1. 40-63 µm / 230-400 mesh (15)

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