SiliaBond® Aluminium Chloride (Si-AlClx) is the silica supported version of the most widely used Lewis acid, aluminium chloride.1 It is an effective catalyst for Friedel-Crafts alkylations2-4 and acylations. It also catalyzes the formation of ethers. The silica supported product has several advantages over the free catalyst5,6:
- Milder Lewis acid. AlCl3 is so reactive that it often lacks of selectivity generating unwanted by-products.
- The steric bulk of the silica reduces over alkylation and increases shelf life.
- Easy work up. The reagent is removed by a simple filtration, avoiding the destructive water quench, which produces large amount of hazardous waste.