SiliaBond^® Tosyl Chloride (Si-TsCl) readily reacts with nucleophiles such as amines and alcohols. Reaction with alcohols yields the bound tosylate, which can then be used to synthesize amines and oxazolines.

SiliaBond^® Isocyanate (Si-ISO) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.

SiliaBond^® Amine (Si-NH₂) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH₂ has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

SiliaBond^® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc¹ and Bsmoc² amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study¹, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.

SiliaBond^® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.⁶ Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.

SiliaBond^® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.⁶ Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.

SiliaBond^® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.

SiliaBond^® Maleimide (Si-MAL) has been designed to scavenge thiols. 90% of mercaptoethanol was removed with 4 eq. after 15 minutes in an aqueous environment. Complete scavenging was observed after 3 hours. SiliaBond Maleimide can also be used to immobilize peptides and proteins through the cysteine residues. 95% of L-cysteine was immobilized after only 15 minutes in a pH 4.5 buffered solution using 4 eq. of SiliaBond Maleimide.

SiliaBond^® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.

SiliaMetS^® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.

SiliaMetS^® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.