
Purification
SiliCycle offers interesting alternative to expedite a wide range of purification typically in the application domains of separation of products mixtures (chromatography) or with SiliaBond®Scavengers, functionalized silica gels designed to react and bind with excess reagents, metal complexes and/or by-products.
Application Notes
All available applications developed for purification purposes are listed below:
For metal removal refer to the following link for more information
-
SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
-
SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
-
SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
-
SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
-
SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
-
SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges Thiol
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges Thiourea
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges TAAcOH
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges TAAcONa
SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
-
SiliaPrep™ SPE Cartridges TMA Acetate nec
SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.
-
SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
-
SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)
SiliaPrep Carboxilic Acid is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
-
SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)
SiliaPrep Carboxilic Acid nec is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
-
SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)
SiliaPrep Diethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.
-
SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)
SiliaPrep TMA Chloride (SAX) is a strong anion exchanger sorbent positively charged under all conditions used to extract acid molecules (pKa 3-5).
-
SiliaPrep™ SPE Cartridges Tosic Acid (SCX)
SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
-
SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)
SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
-
SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
-
SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
-
SiliaPrep™ SPE Cartridges C8/SAX
SiliaPrep C8/SAX is a mixed-mode used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C8/TMA ACETATE nec
SiliaPrep C8/SAX-2 is a mixed-mode used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C8/SCX-2
SiliaPrep C8/SCX-2 is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges SCX-2/SAX
SiliaPrep SCX-2/SAX is a mixed-mode used to separate acidic and basic molecules from non-ionisable molecules.
-
SiliaPrep™ SPE Cartridges C8/SCX-2/SAX
SiliaPrep C8/SCX-2/SAX is a tri-mode extraction and fractionation of acidic, neutral and basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C8/SCX-2/TMA ACETATE nec
SiliaPrep C8/SCX-2/SAX-2 is a tri-mode extraction and fractionation of acidic, neutral and basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C8/SCX
SiliaPrep C8/SCX is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C18/TMA ACETATE nec
SiliaPrep C18/SAX-2 is a mixed-mode sorbent used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C18/SAX
SiliaPrep C18/SAX is a mixed-mode sorbent used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.
-
SiliaPrep™ SPE Cartridges C18/SCX
SiliaPrep C18/SCX is a mixed-mode sorbent used as an alternative to the SiliaPrep C8/SCX & C8/SCX-2 for the extraction of basic compounds requiring more non-polar retention.
-
SiliaPrep™ SPE Cartridges C18/SCX-2
SiliaPrep C18/SCX-2 is a mixed-mode sorbent used as an alternative to the SiliaPrep C8/SCX & C8/SCX-2 for the extraction of basic compounds requiring more non-polar retention.
-
SiliaPrep™ SPE Cartridges C18/WCX
SiliaPrep C18/WCX is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically strong bases and quaternary amines.
-
SiliaPrep™ SPE Cartridges CleanDRUG
SiliaPrepCleanDRUG phase has been optimized for drugs of abuse applications
-
SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Propylsulfonic Acid (SCX-2)
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.
-
SiliaPrep™ SPE Cartridges Cyano
SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.
-
SiliaPrep™ SPE Cartridges Cyano nec
SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.
-
SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Versatile cartridges that can be used either as normal or reversed-phase. Indicated for products with intermediate polarity.





