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Purification

Purification

SiliCycle offers interesting alternative to expedite a wide range of purification typically in the application domains of separation of products mixtures (chromatography) or with SiliaBond®Scavengers, functionalized silica gels designed to react and bind with excess reagents, metal complexes and/or by-products.

Application Notes

All available applications developed for purification purposes are listed below: 

For metal removal refer to the following link for more information

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  1. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep BT flash cartridges are compatible with Biotage i-style compression modules.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  2. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  3. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  4. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  5. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  6. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  7. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  8. SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  9. SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  10. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  11. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  12. SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.

  13. SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep™ SPE Cartridges Carbonate

    SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  14. SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)

    SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)

    SiliaPrep Carboxilic Acid is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.

  15. SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)

    SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)

    SiliaPrep Carboxilic Acid nec is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.

  16. SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)

    SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)

    SiliaPrep Diethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.

  17. SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)

    SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)

    SiliaPrep TMA Chloride (SAX) is a strong anion exchanger sorbent positively charged under all conditions used to extract acid molecules (pKa 3-5).

  18. SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  19. SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  20. SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  21. SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  22. SiliaPrep™ SPE Cartridges C8/SAX

    SiliaPrep™ SPE Cartridges C8/SAX

    SiliaPrep C8/SAX is a mixed-mode used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  23. SiliaPrep™ SPE Cartridges C8/TMA ACETATE nec

    SiliaPrep™ SPE Cartridges C8/TMA ACETATE nec

    SiliaPrep C8/SAX-2 is a mixed-mode used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  24. SiliaPrep™ SPE Cartridges C8/SCX-2

    SiliaPrep™ SPE Cartridges C8/SCX-2

    SiliaPrep C8/SCX-2 is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  25. SiliaPrep™ SPE Cartridges SCX-2/SAX

    SiliaPrep™ SPE Cartridges SCX-2/SAX

    SiliaPrep SCX-2/SAX is a mixed-mode used to separate acidic and basic molecules from non-ionisable molecules.

  26. SiliaPrep™ SPE Cartridges C8/SCX-2/SAX

    SiliaPrep™ SPE Cartridges C8/SCX-2/SAX

    SiliaPrep C8/SCX-2/SAX is a tri-mode extraction and fractionation of acidic, neutral and basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  27. SiliaPrep™ SPE Cartridges C8/SCX-2/TMA ACETATE nec

    SiliaPrep™ SPE Cartridges C8/SCX-2/TMA ACETATE nec

    SiliaPrep C8/SCX-2/SAX-2 is a tri-mode extraction and fractionation of acidic, neutral and basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  28. SiliaPrep™ SPE Cartridges C8/SCX

    SiliaPrep™ SPE Cartridges C8/SCX

    SiliaPrep C8/SCX is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  29. SiliaPrep™ SPE Cartridges C18/TMA ACETATE nec

    SiliaPrep™ SPE Cartridges C18/TMA ACETATE nec

    SiliaPrep C18/SAX-2 is a mixed-mode sorbent used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  30. SiliaPrep™ SPE Cartridges C18/SAX

    SiliaPrep™ SPE Cartridges C18/SAX

    SiliaPrep C18/SAX is a mixed-mode sorbent used to extract acidic compounds from aqueous solutions, typically drugs and metabolites from physiological fluids.

  31. SiliaPrep™ SPE Cartridges C18/SCX

    SiliaPrep™ SPE Cartridges C18/SCX

    SiliaPrep C18/SCX is a mixed-mode sorbent used as an alternative to the SiliaPrep C8/SCX & C8/SCX-2 for the extraction of basic compounds requiring more non-polar retention.

  32. SiliaPrep™ SPE Cartridges C18/SCX-2

    SiliaPrep™ SPE Cartridges C18/SCX-2

    SiliaPrep C18/SCX-2 is a mixed-mode sorbent used as an alternative to the SiliaPrep C8/SCX & C8/SCX-2 for the extraction of basic compounds requiring more non-polar retention.

  33. SiliaPrep™ SPE Cartridges C18/WCX

    SiliaPrep™ SPE Cartridges C18/WCX

    SiliaPrep C18/WCX is a mixed-mode sorbent used to extract basic compounds from aqueous solutions, typically strong bases and quaternary amines.

  34. SiliaPrep™ SPE Cartridges CleanDRUG

    SiliaPrep™ SPE Cartridges CleanDRUG

    SiliaPrepCleanDRUG phase has been optimized for drugs of abuse applications

  35. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Propylsulfonic Acid (SCX-2)

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Propylsulfonic Acid (SCX-2)

    SiliaSep BT flash cartridges are compatible with Biotage i-style compression modules.

    Packed with a strong cation exchanger (SiliaBond® Propylsulfonic Acid), they can be used to fully retain basic compounds for clean-up or to isolate them by “Catch and Release” process.

  36. SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.

  37. SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.

  38. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Cyano

    SiliaSep BT flash cartridges are compatible with Biotage i-style compression modules.

    Versatile cartridges that can be used either as normal or reversed-phase.  Indicated for products with intermediate polarity.

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