SiliaBond® Reagents Kit For Microwave Applications
In recent years, μ-wave synthesizers have taken organic chemistry by storm. Fast kinetics, higher yields, excellent purities, wide compatibility of solvents, and their applicability to a variety of reactions and applications, makes them very important tools in the laboratory. After their introduction, chemists started to use supported reagents for solution-phase synthesis. The polymer supported reagents commonly used, although very useful, have drawbacks in -wave synthesizers: swelling and heat stability. The high temperatures generated inside these synthesizers put stress on these resins. Also, because of the small reaction volumes, the swelling of the resins can be problematic. Silica-based reagents on the other hand, do not suff er from such shortcomings. They are heat resistant and they do not swell.
For your convenience, SiliCycle and CEM Corporation had developed a silica-based reagents kit for μ-wave applications that contains SiliaBond® reagents for diff erent types of reactions (amide synthesis, reductive amination, Suzuki couplings) as well as electrophile, nucleophile, and metal scavenging reactions that demonstrate the eff ectiveness of these reagents in μ-wave applications. You will find general experimental procedure related to each application.
22 Item(s)
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SiliaBond® Diphenylphosphine
SiliaBond® Diphenylphosphine (Si-DPP) can be used as linker for catalyst immobilization such as tetrakis-(triphenylphosphine)palladium(0) for Suzuki coupling.
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SiliaBond® Dimethylamine
SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.
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SiliaBond® Propylsulfonic Acid (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Propylsulfonic Acid nec (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Amine nec
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® Tosic Acid nec (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Tosic Acid (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® Cyanoborohydride
SiliaBond® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica.
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SiliaBond® Carbodiimide (DCC)
SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters.
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SiliaBond® Ethyl Carbodiimide (EDC)
SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).
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SiliaBond® Diethylamine
SiliaBond® Diethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This diethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.
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SiliaMetS® Metal Scavenger Kit
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea -
SiliaBond® Nucleophile Scavenger Kit
Isocyanate - Tosic Acid - Tosyl Chloride -
SiliaBond® Reagent Kit
Carbodiimide - Cyanoborohydride - Dichlorotriazine - DMAP - EDC - HOBt -
SiliaBond® Electrophile Scavenger Kit
Amine - Diamine - Triamine - DMAP - Piperazine - Tosyl Hydrazine -
SiliaMetS® Triamine
SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaMetS® Thiol
SiliaMetS® Thiol (Si-Thiol) is a robust metal scavenger for a variety of metals including Pd, Pt, Cu, Ag and Pb under a wide range of conditions. It has been used in pharmaceutical processes up to the pilot plant scale. It is our most versatile metal scavenger and is the preferred metal scavenger for Pd(II), Cu, Ag, and Hg.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.
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SiliaMetS® Thiourea
SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.
22 Item(s)
List Grid
- Metal to Remove
- Family / Formats
- Phases
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- Amine (3)
- Carbodiimide (DCC) (2)
- Carbonate (1)
- Cyanoborohydride (2)
- Cysteine (1)
- Diamine (2)
- Dichlorotriazine (DCT) (1)
- Diethylamine (1)
- Dimercaptotriazine (DMT) (1)
- Dimethylamine (1)
- Diphenylphosphine (1)
- DMAP (2)
- Ethyl Carbodiimide (EDC) (2)
- HOBt (1)
- Imidazole (1)
- Isocyanate (1)
- Piperazine (1)
- Propylsulfonic Acid (SCX-2) (2)
- TAAcOH (1)
- TAAcONa (1)
- TBD (1)
- Thiol (2)
- Thiourea (2)
- Tosic Acid (SCX) (3)
- Tosyl Chloride (1)
- Tosyl Hydrazine (1)
- Triamine (3)
- Pore Size
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- 60 Å (18)
- Endcapping
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- Endcapped (22)
- Non-endcapped (3)
- Particle Size
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