Drug Development
SiliCycle designs, develops, and manufactures innovative products for world class pharmaceutical companies with gram to multi-tons production capabilities. For large scale purifications, our state-of-the-art facilities allow us to produce high quality chromatographic phases in large batches to supply the most demanding applications.
We are also producing large amount of metal scavengers for the selective removal of spent metal catalysts traces from active pharmaceutical ingredients (API). These ligands bound to silica gel, in bulk or in cartridge formats, are especially designed to remove metal traces down to single digit ppm levels fast and reproducibly. A simple filtration is then performed to get rid of the silica scavenger with the metals entrapped.
We are also producing high quality chromatographic phases for any separation project, large or small. We can supply large quantities of normal, reverse, and ion-exchange phases that will give you the best performance at a competitive price.
Our new line of SiliaCat® heterogeneous catalysts are also very valuable tools for scale-up and process. These catalysts are easy to use and very efficient. At the end of the reaction, a simple filtration removes the spent catalyst and leaves the reaction mixture free of any metal traces.
Furthermore, our technical experts are always there to assist you with any question or to guide you in any given application.
We are your number 1 metal removal solution provider, and your partner of choice for your synthesis, catalysis, analysis and all of your purification requirements.
We commit ourselves to offer you best quality products for price!
- Under a CDA, we will screen a customer’s metal contaminated reaction mixture against our SiliaMetS Metal scavengers to determine the best scavenger and the best conditions.
Custom Phase Synthesis:
- We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.
CONTACT US for more details
- Our team of dedicated specialist will answer your questions, no matter how technical they are.
Products of Interest:
- New SiliaBond® C18
- SiliaMetS® Metal Scavengers
- SiliaBond® Reagents
- SiliaCat® Heterogeneous Catalysts
- SiliaFlash® Irregular Silica Gels
- SiliaSep™ Flash Cartridges HP
- SiliaSep™ Accessories
- SiliaPrep™ SPE (scx-carbonate-NH2)
- SiliaPrep™ Well Plates
- SiliaPlates™ TLC Plates
- METTLER TOLEDO MiniBlock®
Applications:
- Scavenging Palladium Catalysts
- Scavenging Pd(Dppf)Cl2 Catalyst
- SiliaBond® Metal Scavenger: Compatible With RCM Reaction
- SiliaBond® (Bulk) & SiliaPrep™ (SPE) Scavenging Efficiency Comparison
- SiliaBond® Metal Scavenger: Easily Scalable
- Use Of SiliaBond® TMA Acetate
- TFA Removal Using SiliaPrep™ Carbonate
- Scavenging HOBt With SiliaBond® Carbonate
- TLC Troubleshooting: Switching To SiliaPlate™ TLC
- Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
- Reductive Amination - Use Of SiliaBond® Cyanoborohydride
- Friedel-Crafts Alkylation
- Use Of SiliaCat® TEMPO
- Use Of SiliaCat® DPP-Pd
- Use Of SiliaCat® S-Pd
Posters:
- SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
- SiliaBond Metal Scavengers: An Efficient Tool to Remove Metal Residues From Small to Large Scale APIs Synthesis
- Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
- SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates
- SiliaCat TEMPO: an Effective and Recyclable Oxidizing Catalyst
- SiliaCat S-Pd and SiliaCat DPP-Pd: Highly Reactive and Reusable Heterogeneous Silica-Based Palladium Catalysts
- Functionalized Silica Gels for Amide Coupling Reactions
- SiliaBond Carbonate: a Useful Reagent for Amide Synthesis
- New SiliaBond Coupling Reagents to Expedite Amide and Ester Synthesis
- SiliaSep HP Flash Cartridges: New High Performance Separation Tools
- Efficient Peptide-Protein Purification by Flash Chromatography Based on Silica gel - Effect of Pore Size and Hydrophobicity in Reversed Phase Chromatography
20 Item(s)
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SiliaBond® C18 (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.
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SiliaBond® C18 nec (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.
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SiliaBond® C18 (17%)
The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.
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SiliaBond® C18 nec (17%)
This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions. The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.
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SiliaBond® C18 (11%)
SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.
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SiliaSep™ Flash Cartridges C18 nec
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
SiliaSep flash C18 cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges C18
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
SiliaSep flash C18 cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaPrep™ SPE Cartridges C18 nec (23%)
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids and various compounds from water, foods & beverages. Presence of free silanols allows secondary interactions for the extraction of basic compounds.
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SiliaPrep™ SPE Cartridges C18 (17%)
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids.
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SiliaPrep™ SPE Cartridges C18 nec (17%)
SiliaPrep C18 nec is a non-polar sorbent similar to SiliaPrep C18 but presents higher retention and polar selectivity for basic compounds. Unreacted surface OH's can be used for soft condition of catch and release purification of glucoronides for example.
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SiliaPrep™ SPE Cartridges C18 (11%)
SiliaPrep C18 (11%) is a non-polar sorbent used to elute very large hydrophobic molecules that are too strongly retained on higher carbon loading.
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SiliaPrep™ SPE Cartridges C18 nec (11%)
SiliaPrep C18 (11%) is a non-polar sorbent used to elute very large hydrophobic molecules that are too strongly retained on higher carbon loading. Use this less retentive phase for a rapid release of hydrophobic compounds using weaker organic solvents at lower volumes.
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SiliaSphere™ Spherical Silica Gels C18 mono
We offer the SiliaSphere™ C18 as a standard functionalized product in various pore sizes between 60 to 1000Å and in a wide range of particle size (1.8 to 15 µm).
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SiliaSep™ Flash Cartridges - Open Top (OT) C18 nec
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Open Top (OT) C18
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) C18 nec
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) C18
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) C18 nec
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Indicated for the purification of medium to high polarity compounds. They provide reproducible purification without the complexity and cost of preparative HPLC.
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SiliaSep™ SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges C18 nec (23%)
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
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SiliaSep™ Accessories - Pre-packed Luer-Lock Flash Cartridges C18 (17%)
Wether it is for solid-load or dry-load, the pre-packed or empty Luer-Lock cartridges are designed to be used with SiliaSep™ cartridges for sample loading.
20 Item(s)
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- Application Fields
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- Forensic (5)
- Family / Formats
- Pore Size
- Endcapping
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- Endcapped (18)
- Non-endcapped (10)
- Cartridges Volume
- Bed Weight
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- 50 mg (5)
- 100 mg (5)
- 200 mg (5)
- 500 mg (5)
- 1 g (5)
- 2 g (5)
- 4 g (3)
- 5 g (9)
- 8 g (1)
- 9 g (2)
- 10 g (2)
- 12 g (2)
- 15 g (2)
- 20 g (2)
- 25 g (6)
- 40 g (3)
- 45 g (2)
- 50 g (2)
- 65 g (1)
- 70 g (2)
- 80 g (2)
- 90 g (3)
- 100 g (2)
- 120 g (2)
- 135 g (2)
- 200 g (2)
- 220 g (2)
- 270 g (1)
- 330 g (2)
- 350 g (2)
- 400 g (2)
- 800 g (4)
- 1600 g (2)
- Particle Size
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- 3 µm (1)
- 5 µm (1)
- 10 µm (1)
- 15 µm (1)
- 40-63 µm / 230-400 mesh (17)
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