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Drug Discovery

SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.

Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.

We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.

We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!

Metal Scavenging Screening:

  • Under a CDA, we will screen a customer’s metal contaminated reaction mixture against  our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.

Custom Phase Synthesis:

  • We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.

    • CONTACT US for more details

Extensive Technical Support:

  • Our team of dedicated specialist will answer your questions, no matter how technical they are.

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  1. SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Amine

    SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Amine

    SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  2. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  3. SiliaSep™ Flash Cartridges - Open Top (OT) Amine

    SiliaSep™ Flash Cartridges - Open Top (OT) Amine

    SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  4. SiliaSep™ Flash Cartridges Cysteine

    SiliaSep™ Flash Cartridges Cysteine

    SiliaSep flash cysteine cartridges offer a superior alternative to the other cartridges available on the market .

  5. SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep flash TAAcONa cartridges offer a superior alternative to the other cartridges available on the market.

  6. SiliaSep™ Flash Cartridges Amine

    SiliaSep™ Flash Cartridges Amine

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

    SiliaSep flash amine cartridges offer a superior alternative to the other cartridges available on the market.

  7. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  8. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  9. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  10. SiliaMetS® Cysteine

    SiliaMetS® Cysteine

    SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.

  11. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  12. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  13. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

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  1. X Cadmium (Cd): Preferred Scavengers
  2. X Palladium (Pd-2+): Scavenge
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Metal to Remove
Calcium (Ca)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Cobalt (Co)
  1. Preferred Scavengers (1)
  2. Scavenge (7)
Chromium (Cr)
  1. Preferred Scavengers (7)
  2. Scavenge (6)
Cesium (Cs)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Copper (Cu)
  1. Preferred Scavengers (4)
  2. Scavenge (9)
Iron (Fe)
  1. Preferred Scavengers (6)
  2. Scavenge (7)
Mercury (Hg)
  1. Scavenge (7)
Iridium (Ir)
  1. Preferred Scavengers (5)
Lanthanum (La)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Lithium (Li)
  1. Preferred Scavengers (3)
Magnesium (Mg)
  1. Preferred Scavengers (3)
  2. Scavenge (2)
Nickel (Ni)
  1. Preferred Scavengers (4)
Osmium (Os)
  1. Preferred Scavengers (6)
Lead (Pb)
  1. Scavenge (7)
Palladium (Pd-0)
  1. Scavenge (6)
Platinum (Pt)
  1. Preferred Scavengers (7)
  2. Scavenge (2)
Rhodium (Rh-1+)
  1. Preferred Scavengers (7)
  2. Scavenge (6)
Rhodium (Rh-2+)
  1. Preferred Scavengers (7)
  2. Scavenge (6)
Rhodium (Rh-3+)
  1. Preferred Scavengers (3)
Ruthenium (Ru-2+)
  1. Preferred Scavengers (2)
  2. Scavenge (3)
Scandium (Sc)
  1. Preferred Scavengers (5)
Tin (Sn)
  1. Preferred Scavengers (5)
Tungsten (W)
  1. Preferred Scavengers (1)
  2. Scavenge (7)
Zinc (Zn)
  1. Preferred Scavengers (1)
  2. Scavenge (12)
Family / Formats
  1. SiliaBond® (Functionalized Silicas) (1)
  2. SiliaMetS® (Metal Scavengers) (3)
  3. SiliaSep™ (Flash Cartridges) (6)
  4. SiliaPrep™ (SPE Cartridges) (3)
Phases
  1. Amine (7)
  2. Cysteine (2)
  3. Imidazole (1)
  4. TAAcONa (3)
Pore Size
  1. 60 Å (13)
Endcapping
  1. Endcapped (12)
  2. Non-endcapped (2)
Cartridges Volume
  1. 1 mL (2)
  2. 3 mL (2)
  3. 6 mL (3)
  4. 12 mL (3)
  5. 25 mL (3)
  6. 70 mL (1)
  7. 150 mL (1)
  8. 276 mL (1)
Bed Weight
  1. 50 mg (2)
  2. 100 mg (2)
  3. 200 mg (2)
  4. 500 mg (2)
  5. 1 g (3)
  6. 2 g (3)
  7. 4 g (4)
  8. 5 g (4)
  9. 8 g (1)
  10. 9 g (1)
  11. 10 g (1)
  12. 12 g (3)
  13. 15 g (1)
  14. 20 g (1)
  15. 25 g (4)
  16. 40 g (4)
  17. 45 g (1)
  18. 50 g (1)
  19. 70 g (1)
  20. 80 g (3)
  21. 90 g (2)
  22. 100 g (1)
  23. 120 g (3)
  24. 135 g (1)
  25. 200 g (1)
  26. 220 g (3)
  27. 330 g (3)
  28. 350 g (1)
  29. 400 g (1)
  30. 800 g (1)
Particle Size
  1. 40-63 µm / 230-400 mesh (13)

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