Drug Discovery
SiliCycle is a recognized industry leader of innovative methods for more efficiency in drug discovery.
Our products are particularly well suited for drug discovery chemists that perform amide couplings, reductive aminations, metal mediated couplings, etc., on a daily basis. Our supported reagents and catalysts greatly simplify the reaction and work-up process, enabling chemists to run more reactions and generate more compounds. Furthermore, we have a whole range of flash cartridges and TLC plates to assist the chemists in the purification of these compounds.
We are your partner of choice for all your synthesis, catalysis, analysis, purification and metal removal requirements.
We commit ourselves to offer you best quality products accompanied by expert technical support at a competitive price!
- Under a CDA, we will screen a customer’s metal contaminated reaction mixture against our SiliaMetS® Metal scavengers to determine the best scavenger and the best conditions.
Custom Phase Synthesis:
- We have the knowledge to graft any function (small molecules, peptides, sugars, and proteins) onto silica gel and we do that for a customer’ specific application for catalysis, support, or chromatography.
CONTACT US for more details
- Our team of dedicated specialist will answer your questions, no matter how technical they are.
Products of Interest:
- New SiliaBond® C18
- SiliaMetS® Metal Scavengers
- SiliaBond® Reagents
- SiliaCat® Heterogeneous Catalysts
- SiliaFlash® Irregular Silica Gels
- SiliaSep™ Flash Cartridges HP
- SiliaSep™ Accessories
- SiliaPrep™ SPE (scx-carbonate-NH2)
- SiliaPrep™ Well Plates
- SiliaPlates™ TLC Plates
- METTLER TOLEDO MiniBlock®
Applications:
- Scavenging Palladium Catalysts
- Scavenging Pd(Dppf)Cl2 Catalyst
- SiliaBond® Metal Scavenger: Compatible With RCM Reaction
- SiliaBond® (Bulk) & SiliaPrep™ (SPE) Scavenging Efficiency Comparison
- SiliaBond® Metal Scavenger: Easily Scalable
- Use Of SiliaBond® TMA Acetate
- TFA Removal Using SiliaPrep™ Carbonate
- Scavenging HOBt With SiliaBond® Carbonate
- TLC Troubleshooting: Switching To SiliaPlate™ TLC
- Amide Coupling Using SiliaBond® Dichlorotriazine & Carbodiimide
- Reductive Amination - Use Of SiliaBond® Cyanoborohydride
- Friedel-Crafts Alkylation
- Use Of SiliaCat® TEMPO
- Use Of SiliaCat® DPP-Pd
- Use Of SiliaCat® S-Pd
Posters:
- SiliaBond Metal Scavengers: An Efficient Tool to Remove Metal Residues From Small to Large Scale APIs Synthesis
- SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
- Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
- SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates
- SiliaCat TEMPO: an Effective and Recyclable Oxidizing Catalyst
- SiliaCat S-Pd and SiliaCat DPP-Pd: Highly Reactive and Reusable Heterogeneous Silica-Based Palladium Catalysts
- Functionalized Silica Gels for Amide Coupling Reactions
- SiliaBond Carbonate: a Useful Reagent for Amide Synthesis
- New SiliaBond Coupling Reagents to Expedite Amide and Ester Synthesis
- SiliaSep HP Flash Cartridges: New High Performance Separation Tools
- Efficient Peptide-Protein Purification by Flash Chromatography Based on Silica gel - Effect of Pore Size and Hydrophobicity in Reversed Phase Chromatography
29 Item(s)
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SiliaMetS® Metal Scavenger Kit
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea -
SiliaMetS® Triamine
SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.
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SiliaBond® C18 (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.
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SiliaBond® C18 nec (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.
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SiliaBond® C18 (17%)
The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.
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SiliaBond® C18 nec (17%)
This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions. The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.
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SiliaBond® C18 (11%)
SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.
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SiliaBond® C8
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® C8 nec
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® Propylsulfonic Acid (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Propylsulfonic Acid nec (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Amine nec
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® Tosic Acid nec (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Tosic Acid (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® TMA Acetate nec
Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.
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SiliaBond® Cyanoborohydride
SiliaBond® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica.
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SiliaBond® Carbodiimide (DCC)
SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters.
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SiliaBond® Ethyl Carbodiimide (EDC)
SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).
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SiliaBond® Aluminum Chloride
SiliaBond® Aluminium Chloride (Si-AlClx) is the silica supported version of the most widely used Lewis acid, aluminium chloride. It is an effective catalyst for Friedel-Crafts alkylations and acylations. It also catalyzes the formation of ethers.
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SiliaBond® DMAP
SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.
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SiliaBond® Oxidant Kit
Potassium Permanganate - TEMPO - Pyridinium Chlrorochromate - Pyridinium dichromate -
SiliaBond® Reagent Kit
Carbodiimide - Cyanoborohydride - Dichlorotriazine - DMAP - EDC - HOBt -
SiliaBond® Potassium Permanganate nec
Potassium permanganate is a strong oxidant that will oxidize methyl groups and alcohols to carboxylic acids. SiliaBond® Potassium Permanganate (Si-KMnO4) increases recoveries, facilitates work-up, and expands the scope of the chemistry because it can be used in all organic solvents eliminating solubility issues. With SiliaBond Potassium Permanganate, the manganese salt by-products stays adsorbed onto the silica.
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SiliaBond® Pyridinium Chlorochromate nec (PCC)
SiliaBond® Pyridinium Chlorochromate (Si-PCC) is used for the general oxidation of alcohols to carbonyl compounds, selective oxidation of allylic and benzylic alcohols, organometallic oxidation, oxidative transpositions, oxidative cleavages, allylic and benzylic oxidation and oxidative cyclizations.
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SiliaBond® Pyridinium Dichromate nec (PDC)
SiliaBond® Pyridinium Dichromate (Si-PDC) may be used as an alternative to Si-PCC in nucleoside and carbohydrate oxidation, particularly for fragile molecules. SiliaBond PDC can also be used in conjunction with tertbutylhydroperoxide for a variety of oxidative transformations.
29 Item(s)
List Grid
- Metal to Remove
- Phases
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- Aluminum Chloride (1)
- Amine (2)
- C18 (5)
- C8 (2)
- Carbodiimide (DCC) (2)
- Carbonate (1)
- Cyanoborohydride (2)
- Cysteine (1)
- Diamine (1)
- Dichlorotriazine (DCT) (1)
- Dimercaptotriazine (DMT) (1)
- DMAP (2)
- Ethyl Carbodiimide (EDC) (2)
- HOBt (1)
- Imidazole (1)
- Potassium Permanganate (2)
- Propylsulfonic Acid (SCX-2) (2)
- Pyridinium Chlorochromate (PCC) (2)
- Pyridinium Dichromate (PDC) (2)
- TAAcOH (1)
- TAAcONa (1)
- TBD (1)
- TEMPO (1)
- Thiol (1)
- Thiourea (1)
- TMA Acetate (1)
- Tosic Acid (SCX) (2)
- Triamine (2)
- Pore Size
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- 60 Å (26)
- Endcapping
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- Endcapped (23)
- Non-endcapped (6)
- Particle Size
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