SiliaBond® - Acids, Bases & Others
In order to simplify the use and the removal of acids / bases and their salts from reaction mixtures, SiliCycle has developed a range of silica bound SiliaBond acids and bases :
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SiliaBond® Glycidoxy
SiliaBond® Glycidoxy (Si-GLY) may be used as a linker for further modification of the surface and for the immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups.
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SiliaBond® Pyridine
SiliaBond Pyridine (Si-PYR) can be used as a tertiary amine for acid removal. It can also anchor Cu2+ ions and then be used as a catalyst for hydroquinone oxidation.
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SiliaBond® Dimethylamine
SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.
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SiliaBond® Propylsulfonic Acid (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Propylsulfonic Acid nec (SCX-2)
Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
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SiliaBond® Amine nec
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® Allyl
SiliaBond® Allyl (Si-Allyl) can be used as solid support for further derivatization.
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SiliaBond® Bromophenyl
SiliaBond® Bromophenyl (Si-BRP) can be used as solid support for further derivatization.
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SiliaBond® Propyl Bromide
SiliaBond® Propyl Bromide (Si-PBR) is a versatile solid support for amines and alcohols. It is more reactive than the chloride towards displacement.
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SiliaBond® Phenylmethylchloride
SiliaBond® Phenylmethylchloride (Si-PMC) can be used as solid support for further derivatization.
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SiliaBond® Piperazine
SiliaBond® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study1, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.
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SiliaBond® Tosic Acid nec (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Tosic Acid (SCX)
SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.6 Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
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SiliaBond® Tosyl Hydrazine
SiliaBond® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® Morpholine
SiliaBond® Morpholine (Si-MOR) is commonly used as an acid sponge. It is used in the same manner as morpholine functionalized polymers.
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SiliaBond® Carboxylic Acid (WCX)
SiliaBond® Carboxylic Acid (Si-CAA) can be used as a scavenger for amines or carbonates, and for the quench of alkoxides and organometallic reagents. SiliaBond Carboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC.
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SiliaBond® Piperidine
SiliaBond® Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.
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SiliaBond® DMAP
SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.
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SiliaBond® Diethylamine
SiliaBond® Diethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This diethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.
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SiliaBond® Base Kit
Amine - Carbonate - Dimethylamine - Diethylamine - Morpholine - Pyridine - TBD -
SiliaBond® Acid Kit
Carboxylic Acid - Propylsulfonic Acid - TAAcOH - Tosic Acid -
SiliaMetS® Triamine
SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.
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SiliaMetS® TAAcOH
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
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SiliaMetS® Imidazole
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
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SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)
SiliaPrep Carboxilic Acid is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
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SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)
SiliaPrep Carboxilic Acid nec is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
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SiliaPrep™ SPE Cartridges Tosic Acid (SCX)
SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)
SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges TAAcOH
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX) nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Tosic Acid (SCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)
SiliaPrep Piperazine is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. By using this phase, elution can be done at a lower pH (around pH 8-9) comparatively to the SiliaPrep Amine.
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SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)
SiliaPrep Diethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.
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SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ 96 Well Plates Amine
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
- Metal to Remove
- Family / Formats
- Phases
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- Allyl (1)
- Amine (7)
- Bromophenyl (1)
- Carbonate (4)
- Carboxylic Acid (WCX) (6)
- Diamine (3)
- Diethylamine (2)
- Diethylamine (WAX-2) (2)
- Dimethylamine (2)
- DMAP (1)
- Glycidoxy (1)
- Imidazole (1)
- Morpholine (2)
- Phenylmethylchloride (1)
- Piperazine (2)
- Piperidine (1)
- Propyl Bromide (1)
- Propylsulfonic Acid (SCX-2) (7)
- Pyridine (2)
- TAAcOH (3)
- TBD (2)
- Tosic Acid (SCX) (7)
- Tosyl Hydrazine (1)
- Triamine (2)
- Pore Size
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- 60 Å (51)
- Endcapping
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- Endcapped (50)
- Non-endcapped (9)
- Cartridges Volume
- Bed Weight
- Particle Size
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