SiliCycle offers a wide range of scavengers to simplify your purifications.
Scavengers are functionalized silica gels designed to react and bind excess reagents, metal complexes and/or by-products.More Information
The process for using scavengers is outlined in the scheme shown below. In the case of batch processing, the scavenger is added to the reaction mixture after completion. The process relies on chemically driven reactions where the excess reagents and reaction by-products react with and bind to the scavenger. The solution, which now only contains the product of interest, is separated from the silica bound impurities by filtration.
For flow through processing, the scavenger is packed into a column and the reaction mixture is passed through the column until complete scavenging is obtained.
SiliCycle Available Scavengers:
SiliaBond® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study1, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.
Amine - Diamine - Triamine - DMAP - Piperazine - Tosyl Hydrazine
SiliaPrep Piperazine is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. By using this phase, elution can be done at a lower pH (around pH 8-9) comparatively to the SiliaPrep Amine.