Removing residual metals from post reactions can be a major issue. The toxic nature of transition metals has led to the reduction of tolerated residual concentration in active pharmaceutical ingre-dients (APIs) to single digit ppm. However, many important key steps, such as coupling reactions (Suzuki, Heck, Stille, Sonogashira, etc), ring closing metathesis (RCM), and hydrogenation, still require the use of metal catalysts.

Founded in 1995, SiliCycle^® Inc. is a fine chemistry company specialized in the development, the manufacturing and the commercialization of silica gel products for chromatography, analytical and organic chemistry.

SiliCycle's business extends to more than fifty countries worldwide and its customer portfolio includes companies in the pharmaceutical, biotechnology industries, contract research and manufacturing organizations as well as university laboratories and hospital research centers.

SiliCycle manufactures a variety of HPLC columns for reversed and normal phases applications. The SiliaChrom^® series contain more than 20 different phases produced in our own laboratories, and we continue to develop additional unique and powerful HPLC columns. In fact, you can be completely assured of the quality, from raw material synthesis through packing, testing and customer applications.