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What are metal scavengers?

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Metal scavengers are functionalized silica gels designed to react and bind excess metal complexes.

scheme of metal scavenging process

In recent years, the time pressure associated with quickly bringing candidate drugs to market has increased the number of transition metal-catalyzed reactions being transferred from lead optimization to early scale-up. The removal of post-reactions metal residues has become a major issue in the pharmaceutical industry.

Purification of APIs from residual metal catalyst by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such as high costs, time loss, low efficiency, and reduced API yields.

Traditional purification means are good but not great:

  • Crystallization involves a compound exposed for a long time to high temperatures, increasing the risk for thermal degradation. It is expensive, and total recovery is hard to achieve.
  • Solvent Extraction is long, implies large volumes of solvents, often implies colored and viscous extracts, and is hardly optimizable.
  • Chromatography is effective but also very expensive, consumes large quantities of solvents (hence requiring further downstream processing) and poorly suitable for large scale operations.

Silica-based metal scavengers have been proven to be the purification method of choice over all other methods and several companies from various industries use them. With the silica matrix advantages over polymers (no swelling, more general solvent compatibility, higher mechanical and thermal stabilities, applications easily scalables and products available in different formats, i.e. SPE, flash cartridges, bulk, etc.) silica metal scavengers are the solution for metal removal without contamination of drug candidates.

Learn more:

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  1. SiliaMetS metal scavenger kit (K30730B). Includes the following products: Cysteine, DMT, Imidazole, Triamine, TAAcOH, TAAcONa, Thiol & Thiourea

    SiliaMetS® Metal Scavenger Kit (K30730B)

    This metal scavenger kit includes the following products: Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea
  2. SiliaMetS Novel Scavenger Kit. Includes the following products: AMPA - DEAM - DOTA - DMT - Guanidine - Thiol

    SiliaMetS® Novel Scavenger Kit (K34530B)

    This metal scavenger kit includes the following products: AMPA - DEAM - DOTA - DMT - Guanidine - Thiol
  3. SiliaMetS Tin Metal Scavenger Kit (K34730B) - Includes the following products: Carbonate - Cysteine - DEAM - DMT - TAAcOH - TAAcONa - Thiourea - Thiol

    SiliaMetS® Tin Metal Scavenger Kit (Carbonate; Cysteine; DEAM; DMT; TAAcOH; TAAcONa; Thiol; Thiourea) (K34730B)

    SiliaMetS® Tin Metal Scavenger Kit: Carbonate; Cysteine; DEAM; DMT; TAAcOH; TAAcONa; Thiol; Thiourea
  4. SiliaMetS Palladium Metal Scavenger Kit - Includes: DMT - Diamine - Thiol - Thiourea - Imidazole - Triamine

    SiliaMetS® Palladium Metal Scavenger Kit (K34630B)

    This kit includes the following products : DMT - Diamine - Thiol - Thiourea - Imidazole - Triamine
  5. Periodic Table of Metals Removed by SiliaMetS Metal Scavengers

    Periodic Table of Metals Removed by SiliaMetS Metal Scavengers

    Flyer (11 x 8.5 in.) - Group of metals removed by SiliaMetS Metal Scavengers
  6. Experimental Procedures for Scavengers (Metal & Organic)

    Experimental Procedures for Scavengers (Metal & Organic)

    Pamphlet (6 pages) - A step-by-step guide for all practical and experimental questions that might rise concerning the use of Silicycle's silica-based scavengers.
  7. SiliCycle range of silica-based scavengers for the removal of metal and/or organic compounds

    Choosing your metal & organic scavenging solution

    Poster (36 x 24 in.) - Helps to choose among SiliCycle's unparalleled range of Metal and Organic Scavengers, SiliaMetS® and SiliaBond®.
  8. Metal Scavenging with SiliaMetS® AMPA

    Metal Scavenging with SiliaMetS® AMPA

    Application Note (7 pages) - SiliCycle's SiliaMetS AMPA effectively eliminates Iron, Copper, Zinc, Manganese, Lanthanides, Antimony and Nickel.
  9. Metal Scavenging with SiliaMetS® DEAM

    Metal Scavenging with SiliaMetS® DEAM

    Application Note (7 pages) - SiliaMetS DEAM effectively eliminates trace metals and boronic acids from products.
  10. Scavenging of Nucleophiles and Basic Reactivity with SiliaBond® Guanidine

    Scavenging of Nucleophiles and Basic Reactivity with SiliaBond® Guanidine

    Application Note (7 pages) - SiliCycle's SiliaBond® Guanidine effectively eliminates organic acids and may be used as a strong base.
  11. Scavenging of Pd(dt-bpf)Cl2

    Scavenging of Pd(dt-bpf)Cl2

    Application Note (7 pages) - Pd(dt-bpf )Cl2 is a strong, homogeneous catalyst that has been shown to be very stable and active for all coupling reactions, especially aminations, reductive carbonylations and Suzuki couplings.

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