What is the Catch and Release technique?
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Catch & release is a term used when a molecule is temporarily bound to functionalized silica (with either an ionic or a covalent bond) and subsequently released. This is done to facilitate purification or synthesis.
A very popular example of Catch & Release purification is the purification of amines with tosic acid silica, a Strong Cation Exchanger (SCX). The tosic acid grafted silica will catch the basic amines out of the reaction mixture, allowing all other impurities to be washed away with a neutral solvent such as methanol or dichloromethane. The amines are then released by switching to a basic solvent such as 5 % ammonia in methanol or triethylamine in dichloromethane. Catch & Release purification can easily be adapted in SPE format for automation purposes.
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SiliCycle's Most Popular Functionalized Silicas
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Solutions For Purification and Chromatography (BROPUR)
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