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What is the Catch and Release technique?

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Catch & release is a term used when a molecule is temporarily bound to functionalized silica (with either an ionic or a covalent bond) and subsequently released. This is done to facilitate purification or synthesis.

A very popular example of Catch & Release purification is the purification of amines with tosic acid silica, a Strong Cation Exchanger (SCX). The tosic acid grafted silica will catch the basic amines out of the reaction mixture, allowing all other impurities to be washed away with a neutral solvent such as methanol or dichloromethane. The amines are then released by switching to a basic solvent such as 5 % ammonia in methanol or triethylamine in dichloromethane. Catch & Release purification can easily be adapted in SPE format for automation purposes.

 

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  1. Poster - SiliCycle's Most Popular Functionalized Silicas

    SiliCycle's Most Popular Functionalized Silicas

    Poster - Download our free poster of the most popular functionalized silicas and their main purification applications whether for chromatography, metal & organic scavenging or as reagents & oxidants.
  2. Solutions For Purification & Chromatography (BROPUR)

    Solutions For Purification and Chromatography (BROPUR)

    Brochure, 48 pages. Product lines: SiliaFlash Bulk Irregular Silica for Chromatography, SiliaSphere Bulk Spherical Silica for Chromatography, SiliaBond Chromatographic Phases, SiliaSep Flash Cartridges and SiliaPlate TLC Plates

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