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Case Studies - Microwave
Assisted Scavenging
Microwave Assisted Scavenging
This rapidly growing field is highly compatible with silica bound
scavengers and reagents. Below(table1) are the results using Si – Amine(figure
1) to scavenge a variety of nucleophiles. The scavenging was carried
out using 4 equiv under mircowave conditions: 4 min, 150°C,
300W. No leaching of the reactive groups was obeserved by GC-MS.
The integrity of the functionalized silica gel under microwave
conditions (700W, 30 min) is not affected.
| Nucleophile |
% Scavenged |
| Benzaldehyde |
97 |
| Benzoyl chloride |
100 |
| Acetic Anhydride |
99 |
| 1,1,3,3-Tetramethylbutylisocyanate |
100 |
| Tert-butylphenylisocyanate |
100 |
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| Table 1: |
| Nucleophile scavenging with Si- Amine under
microwave conditions. Reactions were run by CEM corporation on
a Discover™ synthesizer 4min, 150°C, 300W |
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