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SiliaBond® - Chromatographic Phases

The sorbent required for the purification of a specific substrat will vary according to the structure of the said substrate.  Wether it is ionized or neutral and depending on its polarity and solubility, the appropriated chromatographic stationary phase will vary.  In order to better fulfill those different needs, SiliCycle offer a wide variety of sorbents for normal and reversed-phase.  Please refer to the sorbent selection guide to select the most appropriated phase.

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  1. SiliaBond® C18 (23%)

    SiliaBond® C18 (23%)

    SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.

  2. SiliaBond® C18 nec (23%)

    SiliaBond® C18 nec (23%)

    SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.

  3. SiliaBond® C18 (16%)

    SiliaBond® C18 (16%)

    The SiliaBond® C18 16% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.

  4. SiliaBond® C18 (17%) Polymeric

    SiliaBond® C18 (17%) Polymeric

    The homogeneous coverage of the polymeric C18 ensures great separation for hydrophobic compounds with lot-to-lot high reproducibility and inhibits the non-specific interaction with residual silanols. The SiliaBond Polymeric C18 (17%) is the traditional matrix for reversed-phase chromatography. Considered as the least selective phase since it interacts with wide range of organics and biological molecules.

  5. SiliaBond® C18 (11%)

    SiliaBond® C18 (11%)

    SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.

  6. SiliaBond® C8

    SiliaBond® C8

    SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.

  7. SiliaBond® C8 nec

    SiliaBond® C8 nec

    SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.

  8. SiliaBond® C4

    SiliaBond® C4

    SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules.  It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.

  9. SiliaBond® Silver Nitrate  (AgNO3) nec

    SiliaBond® Silver Nitrate (AgNO3) nec

    Chromatography with silver nitrate is a well known and established methodology for the separation of non polar compounds with similar polarities. Generally, with a mixture of unsaturated compounds such as alkenes, lipids, steroids, terpenes, etc, standard separation procedures lack in efficiency. However, by using SiliaBond® Silver Nitrate for your column chromatography along with SiliaPlate Ag for your TLC, you will have the necessary tools to circumvent the problem.

  10. SiliaBond® C4 nec

    SiliaBond® C4 nec

    SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules.  It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.

  11. SiliaBond® C1

    SiliaBond® C1

    SiliaBond® C1 (or C1) has the lowest degree of hydrophobicity of all reversed stationary phases, useful in the separation of large biomolecules that have extensive hydrophobic regions.

  12. SiliaBond® Phenyl

    SiliaBond® Phenyl

    SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.

  13. SiliaBond® Phenyl nec

    SiliaBond® Phenyl nec

    SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.

  14. SiliaBond® Diol

    SiliaBond® Diol

    SiliaBond Diol may also be used as polar sorbent in normal phase and aqueous size exclustion chromatography. Like bare silica, SiliaBond Diol has the ability to form hydrogen bonds and the capacity to separate structural isomers. Since most of its surface is covered with organic functions, the SiliaBond Diol absorbs less water, which leads to a more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water.

  15. SiliaBond® Cyano

    SiliaBond® Cyano

    SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.

  16. SiliaBond® Cyano nec

    SiliaBond® Cyano nec

    SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.

  17. SiliaBond® Dimethylamine

    SiliaBond® Dimethylamine

    SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.

  18. SiliaBond® Propylsulfonic Acid (SCX-2)

    SiliaBond® Propylsulfonic Acid (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  19. SiliaBond® Propylsulfonic Acid nec (SCX-2)

    SiliaBond® Propylsulfonic Acid nec (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  20. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  21. SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.


  22. SiliaBond Tosic Acid (SCX) metal scavenger

    SiliaBond® Tosic Acid (SCX)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  23. SiliaBond Cyclohexyl (Si-CYH) is a sorbent of medium polarity used in reversed-phase chromatography. It has a different selectivity than the alkyl sorbents (C18, C8, C4, …) and phenyl, and may be used when these fail to provide the desired selectivity.

    SiliaBond® Cyclohexyl

    SiliaBond Cyclohexyl (Si-CYH) is a sorbent of medium polarity used in reversed-phase chromatography. It has a different selectivity than the alkyl sorbents (C18, C8, C4, ...) and phenyl, and may be used when these fail to provide the desired selectivity.
  24. SiliaBond® Tridecafluoro

    SiliaBond® Tridecafluoro

    SiliaBond® Tridecafluoro (Si-TDF) is a sorbent primarily used to separate fluorinated molecules. It can also be used in fluorous solid-phase extraction (FSPE) of fluorous-tag compounds as reported for the synthesis of oligosaccharide.


  25. SiliaBond® Fluorochrom

    SiliaBond® Fluorochrom

    SiliaBond® Fluorochrom (Si-FCM) is a fluorinated sorbent particularly useful for the separation of fluorine containing molecules from non-fluorous ones. The applications of these types of sorbent are not limited to fluorous compounds but may also be used in chromatographic separation of non-fluorinated molecules, just like a regular reversed-phase would do, but with different selectivity. SiliaBond Fluorochrom presents the highest level of fluorine available and has a proprietary structure.


  26. SiliaBond® TBA Chloride

    SiliaBond® TBA Chloride

    SiliaBond® TBA Chloride (Si-TBACl) may be used in the same way as SiliaBond TMA Chloride. Si-TBACl is more sterically indered, which offers a different selectivity than other anion exchangers.

  27. SiliaBond® TMA Chloride nec (SAX)

    SiliaBond® TMA Chloride nec (SAX)

    SiliaBond® TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents.

  28. SiliaBond® TMA Acetate nec

    SiliaBond® TMA Acetate nec

    Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.

  29. SiliaBond® TMA Chloride (SAX)

    SiliaBond® TMA Chloride (SAX)

    SiliaBond® TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents.

  30. SiliaBond Urea (Si-Urea) can be used for cationic surfactants adsorbtion and as polar stationary phase for chromatography

    SiliaBond® Urea

    SiliaBond® Urea (Si-Urea) can be used for cationic surfactants adsorbtion1 and as polar stationary phase for chromatography.
  31. SiliaBond® Pentafluorophenyl

    SiliaBond® Pentafluorophenyl

    SiliaBond® Pentafluorophenyl (Si-PFP) is a sorbent primarily used in the separation of molecules bearing fluorine atoms but may also be used in the separation of non-fluorous compounds such as Taxol® and its derivatives. Because of its phenyl ring, Si-PFP has a higher selectivity for aromatics containing molecules compared to the other fluorinated sorbents.

  32. SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (Si-CAA) can be used as a scavenger for amines or carbonates, and for the quench of alkoxides and organometallic reagents. SiliaBond Carboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC.

  33. SiliaBond Triethylamine ion exchange chromatographic phase

    SiliaBond® Triethylamine

    SiliaBond® Triethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This triethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.

  34. SiliaBond® Reversed-Phase Kit

    SiliaBond® Reversed-Phase Kit

    C8 monomeric - C18 (17%) polymeric - C18 (17%) monomeric - C18 (23%) - Cyano - Phenyl
  35. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  36. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and in normal phase conditions.

  37. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  38. SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep™ SPE Cartridges Cyano

    SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.

  39. SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep™ SPE Cartridges Cyano nec

    SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.

  40. SiliaPrep™ SPE Cartridges Diol

    SiliaPrep™ SPE Cartridges Diol

    SiliaPrep Diol nec is a moderate polar sorbent presenting neutral character used to extract polar compounds from non-polar solvents, structural isomers. Alternative to silica when the acidic character is problematic.

  41. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  42. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  43. SiliaPrep™ 96 Well Plates Cyano

    SiliaPrep™ 96 Well Plates Cyano


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  44. SiliaPrep™ 96 Well Plates Cyano nec

    SiliaPrep™ 96 Well Plates Cyano nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  45. SiliaPrep™ 96 Well Plates Diol

    SiliaPrep™ 96 Well Plates Diol


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  46. SiliaPrep™ SPE Cartridges Pentafluoprophenyl

    SiliaPrep™ SPE Cartridges Pentafluoprophenyl

    SiliaPrep Pentafluorophenyl is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones. The electron density presents fluorinated aromatic ring which affords an enhancement in the retention of conjugated and aromatic ring-containing due to the desirable pi-pi interactions. Excellent alternative of the C18 when the C18 presents a selectivity problem.

  47. SiliaPrep™ SPE Cartridges Fluorochrom

    SiliaPrep™ SPE Cartridges Fluorochrom

    SiliaPrep Fluorochrom is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.

  48. SiliaPrep™ SPE Cartridges Tridecafluoro

    SiliaPrep™ SPE Cartridges Tridecafluoro

    SiliaPrep Tridecafluoro is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.

  49. SiliaPrep™ 96 Well Plates Pentafluorophenyl

    SiliaPrep™ 96 Well Plates Pentafluorophenyl


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  50. SiliaPrep™ 96 Well Plates Fluorochrom

    SiliaPrep™ 96 Well Plates Fluorochrom


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.

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