SiliaBond® Diol (Si-Diol) may be used as boronic acid scavenger in the same way as PS-DEAM.
SiliaBond Diol may also be used as polar sorbent in normal phase and aqueous size exclustion chromatography. Like bare silica, SiliaBond Diol has the ability to form hydrogen bonds and the capacity to separate structural isomers. Since most of its surface is covered with organic functions, the SiliaBond Diol absorbs less water, which leads to a more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water. It has a different selectivity than bare silica gel and slight modifications in the composition of the solvent mixture may be necessary to obtain similar retention. In SPE, it is used for the isolation of drugs and metabolites from physiological fluids.
- Org. Lett., 6 (2004) 2317