Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.
SiliCycle offers SiliaBond Propylsulfonic Acid (SCX-2) and SiliaBond Tosic Acid (SCX). Both are considered strong cation exchanger as they maintain a negative charge throughout the pH scale. The aromatic ring of the SiliaBond Tosic Acid makes it slightly more acidic than the other. However, tests have demonstrated that they both have comparable strength. The difference between the two products is mainly in the selectivity. SiliaBond SCX-2 presents a slightly more non-polar character than the SiliaBond SCX, thus reducing secondary non-polar interactions with compounds.
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- Electrochem. Comm., 11 (2009) 305