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SiliaBond® Amine

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SiliaBond® Amine

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Product Number Quantity  
R52030B-5g 5 g

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R52030B-10g 10 g

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R52030B-25g 25 g

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R52030B-50g 50 g

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R52030B-100g 100 g

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R52030B-250g 250 g

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R52030B-500g 500 g

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R52030B-1kg 1 kg

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Product Description

Specifications

Documentations


 
  • Details

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Researchers compared PS-Triamine to SiliaBond Amine for the removal of acid chlorides in the synthesis of 2,9-disubstituted guaninies. Using SiliaBond Amine to remove excess acid chloride gave higher yields and better purity in more than 93% compared to PS-Trisamine. For complete details, please refer to the scavenger case study.1

    SiliaBond Amine eliminates tedious post reaction purification. It scavenges faster, is easier to add and filter, and can be used in any solvent. Si-NH2 has been shown to be effective metal scavenger2 and catalyst for Knoevenagel reactions.3, 4  It has also been used as support in solid-phase chemistry for peptide synthesis followed by enzymatic hydrolysis5 and for Claisen rearrangement.6

    SiliaBond Amine is also used in chromatography as normal phase sorbent. It is used in the preparation of peptides, drugs and metabolites from physiological fluids and for the separation of mono- and polysaccharides.  Si-NH2 is more retentive towards basic compounds. When used at pH ≤ 7.8, it is protonated and may be used as a weak anion exchanger (WAX). SiliaBond Amine has been used for the solid-phase extraction of sugars,7 for the separation of steroids,8 cholesterol, and triglycerides,9 and in size exclusion chromatography of cationic polymers.10  Si-NH2 is also available non-endcapped (R52130B) for additional retention of polar and cationic compounds.

    APPLICATION NOTES
    Click here to see the application notes about SiliaBond®

    POSTERS
    Click here to see all the documentation about SiliaBond®

    RELATED PUBLICATIONS

    1. Tet. Lett., 41 (2000) 3573
    2. Chem. Commun., (2000) 1145
    3. Tet. Lett., 29 (1988) 2261
    4. J. Chem. Soc. Perk. Trans. I, (1989) 105
    5. Tet. Lett., 44 (2003) 6083
    6. Molecular Diversity, 3 (1998) 161
    7. J. Liq. Chromato., 14 (1991) 1185
    8. J. Chromato. A, 392 (1987) 464
    9. J. Chromato. B, 434 (1988) 395
    10. J. Chromato. A, 389 (1987) 103
  • Additional Information

    Array AQ C18
    Family / Formats SiliaBond® (Functionalized Silicas)
    Particle Size 40-63 µm / 230-400 mesh
    Pore Size 60 Å
    Endcapping Endcapped
    Storage Condition Keep dry and cool (<8°C)
    Solvent Compatibility All solvents, aqueous and organic
    Typical Tap Density 700 g/L
    Molecular Loading 1.20 mmol/g
    Color Orange
    Cadmium (Cd) Preferred Scavengers
    Chromium (Cr) Preferred Scavengers
    Cobalt (Co) Scavenge
    Copper (Cu) Scavenge
    Iron (Fe) Scavenge
    Mercury (Hg) Scavenge
    Lead (Pb) Scavenge
    Palladium (Pd-2+) Scavenge
    Platinum (Pt) Preferred Scavengers
    Rhodium (Rh-1+) Preferred Scavengers
    Rhodium (Rh-2+) Preferred Scavengers
    Tungsten (W) Scavenge
    Zinc (Zn) Scavenge