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SiliaBond®- Ion Exchanges

The sorbent required for the purification of a specific substrat will vary according to the structure of the said substrate.  Wether it is ionized or neutral and depending on its polarity and solubility, the appropriated chromatographic stationary phase will vary.  In order to better fulfill those different needs, SiliCycle offers a wide variety of sorbents including ion exchanger resin.  These latest can also be used in “Catch and Release” purification technique (see application notes section for detailed protocol).  Please refer to the sorbent selection guide to select the most appropriated phase.

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  1. SiliaBond® Propylsulfonic Acid (SCX-2)

    SiliaBond® Propylsulfonic Acid (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  2. SiliaBond® Propylsulfonic Acid nec (SCX-2)

    SiliaBond® Propylsulfonic Acid nec (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  3. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  4. SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.


  5. SiliaBond Tosic Acid (SCX) metal scavenger

    SiliaBond® Tosic Acid (SCX)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  6. SiliaBond® TBA Chloride

    SiliaBond® TBA Chloride

    SiliaBond® TBA Chloride (Si-TBACl) may be used in the same way as SiliaBond TMA Chloride. Si-TBACl is more sterically indered, which offers a different selectivity than other anion exchangers.

  7. SiliaBond® TMA Chloride nec (SAX)

    SiliaBond® TMA Chloride nec (SAX)

    SiliaBond® TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents.

  8. SiliaBond® TMA Acetate nec

    SiliaBond® TMA Acetate nec

    Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.

  9. SiliaBond® TMA Chloride (SAX)

    SiliaBond® TMA Chloride (SAX)

    SiliaBond® TMA Chloride (SiliaBond SAX, Si-TMACl) is mainly used as strong anion exchanger (SAX) in ion chromatography and ion exchange SPE. The function bears a positive charge across the whole pH range as well as in organic solvents.

  10. SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (Si-CAA) can be used as a scavenger for amines or carbonates, and for the quench of alkoxides and organometallic reagents. SiliaBond Carboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC.

  11. SiliaBond Triethylamine ion exchange chromatographic phase

    SiliaBond® Triethylamine

    SiliaBond® Triethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This triethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.

  12. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  13. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and in normal phase conditions.

  14. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  15. SiliaPrep™ SPE Cartridges Triethylamine (WAX-2)

    SiliaPrep™ SPE Cartridges Triethylamine (WAX-2)

    SiliaPrep Triethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.

  16. SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)

    SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)

    SiliaPrep TMA Chloride (SAX) is a strong anion exchanger sorbent positively charged under all conditions used to extract acid molecules (pKa 3-5).

  17. SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep™ SPE Cartridges TMA Acetate nec

    SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.

  18. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  19. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  20. SiliaPrep™ 96 Well Plates Diethylamine (WAX-2)

    SiliaPrep™ 96 Well Plates Triethylamine (WAX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  21. SiliaPrep™ 96 Well Plates TMA Chloride nec (SAX)

    SiliaPrep™ 96 Well Plates TMA Chloride nec (SAX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  22. SiliaPrep™ 96 Well Plates TMA Acetate nec

    SiliaPrep™ 96 Well Plates TMA Acetate nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  23. SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)

    SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)

    SiliaPrep Carboxylic Acid is a weak cation exchanger sorbent (WCX) used to extract strong basic compounds.

  24. SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)

    SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)

    SiliaPrep Carboxilic Acid nec is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.

  25. SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  26. SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  27. SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)

    SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  28. SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)

    SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  29. SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX)

    SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  30. SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX) nec

    SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX) nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  31. SiliaPrep™ 96 Well Plates Tosic Acid (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  32. SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  33. SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)

    SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  34. SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)

    SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.

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