SiliaBond® Pyridinium Dichromate (Si-PDC) may be used as an alternative to Si-PCC in nucleoside and carbohydrate oxidation, particularly for fragile molecules.1 SiliaBond PDC can also be used in conjunction with tertbutylhydroperoxide for a variety of oxidative transformations.2
PDC immobilized onto silica is a very convenient and effective reagent for oxidizing allylic and benzylic alcohols, saturated primary and secondary alcohols, and is compatible with acid-sensitive groups, such as cyclopropane ring or ketal function.3
Oxidation of 4-tert-butylcyclohexanol to 4-tert-butylcyclohexanone with 2 eq. of Si-PDC in anhydrous DCM at room temperature is complete after 6 hours.
Oxidation of Alcohols
- J. Chem. Soc. Perkin Trans. I, (1982) 1967
- J. Chem. Soc. Chem. Commun., 7 (1993) 651
- Tetrahedron, 35 (1979) 1789