SiliaBond® Amine

SiliaBond^® Amine (Si-NH₂) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Researchers compared PS-Triamine to SiliaBond Amine for the removal of acid chlorides in the synthesis of 2,9-disubstituted guaninies. Using SiliaBond Amine to remove excess acid chloride gave higher yields and better purity in more than 93% compared to PS-Trisamine. For complete details, please refer to the scavenger case study.¹

SiliaBond Amine eliminates tedious post reaction purification. It scavenges faster, is easier to add and filter, and can be used in any solvent. Si-NH₂ has been shown to be effective metal scavenger² and catalyst for Knoevenagel reactions.^{3, 4}  It has also been used as support in solid-phase chemistry for peptide synthesis followed by enzymatic hydrolysis⁵ and for Claisen rearrangement.⁶

SiliaBond Amine is also used in chromatography as normal phase sorbent. It is used in the preparation of peptides, drugs and metabolites from physiological fluids and for the separation of mono- and polysaccharides.  Si-NH₂ is more retentive towards basic compounds. When used at pH ≤ 7.8, it is protonated and may be used as a weak anion exchanger (WAX). SiliaBond Amine has been used for the solid-phase extraction of sugars,⁷ for the separation of steroids,⁸ cholesterol, and triglycerides,⁹ and in size exclusion chromatography of cationic polymers.¹⁰  Si-NH₂ is also available non-endcapped (R52130B) for additional retention of polar and cationic compounds.

APPLICATION NOTES
Metal Removal
Scavenging Palladium Catalysts
Scavenging Acid Chloride
Scavenging Phenylchloroformate

POSTERS
Silica-Based Reagents Kit for µ-Waves Applications
Silica Based Metal Scavengers for the Purification of Active Pharmaceutical Ingredients
SiliaBond Metal Scavengers: Useful Tool for the Purification of Active Pharmaceutical Ingredients
Efficient Removal of Ruthenium-Based Catalysts Using SiliaBond Metal Scavengers
SiliaBond Metal Scavengers: an Efficient Tool to Remove Metal Residues from API's and their Intermediates

RELATED PUBLICATIONS

1. Tet. Lett., 41 (2000) 3573
2. Chem. Commun., (2000) 1145
3. Tet. Lett., 29 (1988) 2261
4. J. Chem. Soc. Perk. Trans. I, (1989) 105
5. Tet. Lett., 44 (2003) 6083
6. Molecular Diversity, 3 (1998) 161
7. J. Liq. Chromato., 14 (1991) 1185
8. J. Chromato. A, 392 (1987) 464
9. J. Chromato. B, 434 (1988) 395
10. J. Chromato. A, 389 (1987) 103

PRODUCT SPECIFICATIONS

MSDS-R51030B