SiliaBond®- Bases
In order to simplify the use and the removal of bases and their salts from reaction mixtures, SiliCycle has developed a range of silica bound SiliaBond bases :
15 Item(s)
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SiliaBond® Pyridine
SiliaBond Pyridine (Si-PYR) can be used as a tertiary amine for acid removal. It can also anchor Cu2+ ions and then be used as a catalyst for hydroquinone oxidation.
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SiliaBond® Dimethylamine
SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.
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SiliaBond® Amine nec
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® Piperazine
SiliaBond® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study1, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.
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SiliaBond® Tosyl Hydrazine
SiliaBond® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® Morpholine
SiliaBond® Morpholine (Si-MOR) is commonly used as an acid sponge. It is used in the same manner as morpholine functionalized polymers.
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SiliaBond® Piperidine
SiliaBond® Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.
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SiliaBond® DMAP
SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.
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SiliaBond® Diethylamine
SiliaBond® Diethylamine (SiliaBond WAX-2) is a silica bound tertiary amine base and can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This diethylamine immobilized on silica gel can be used for the same applications as SiliaBond Dimethylamine. It is a very common supported tertiary amine.
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SiliaBond® Base Kit
Amine - Carbonate - Dimethylamine - Diethylamine - Morpholine - Pyridine - TBD -
SiliaMetS® Triamine
SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaBond® TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.
15 Item(s)
List Grid
- Metal to Remove
- Phases
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- Amine (3)
- Carbonate (2)
- Diamine (1)
- Diethylamine (2)
- Dimethylamine (2)
- DMAP (1)
- Morpholine (2)
- Piperazine (1)
- Piperidine (1)
- Pyridine (2)
- TBD (2)
- Tosyl Hydrazine (1)
- Triamine (1)
- Pore Size
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- 60 Å (14)
- Endcapping
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- Endcapped (15)
- Particle Size
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