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SiliaBond®- Scavengers

SiliCycle offers a wide range of scavengers to simplify your purifications.

Scavengers are functionalized silica gels designed to react and bind excess reagents, metal complexes and/or by-products.More Information

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The process for using scavengers is outlined in the scheme shown below. In the case of batch processing, the scavenger is added to the reaction mixture after completion. The process relies on chemically driven reactions where the excess reagents and reaction by-products react with and bind to the scavenger. The solution, which now only contains the product of interest, is separated from the silica bound impurities by filtration.

For flow through processing, the scavenger is packed into a column and the reaction mixture is passed through the column until complete scavenging is obtained.

whats a scavengers

SiliCycle Available Scavengers:

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  1. SiliaBond® Tosyl Chloride

    SiliaBond® Tosyl Chloride

    SiliaBond® Tosyl Chloride (Si-TsCl) readily reacts with nucleophiles such as amines and alcohols. Reaction with alcohols yields the bound tosylate, which can then be used to synthesize amines and oxazolines.

  2. SiliaBond® Isocyanate

    SiliaBond® Isocyanate

    SiliaBond® Isocyanate (Si-ISO) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.

  3. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  4. SiliaBond® Piperazine

    SiliaBond® Piperazine

    SiliaBond® Piperazine (Si-PPZ) is a useful deprotecting and scavenging agent for Fmoc1 and Bsmoc2 amino protecting groups and as a solid-phase Knoevenagel catalyst. According to the results of a study1, Si-PPZ is superior to its polystyrene-based equivalent. SiliaBond Piperazine may also be used to scavenge electrophiles.


  5. SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid nec (SCX)

    SiliaBond® Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions.Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.


  6. SiliaBond Tosic Acid (SCX) metal scavenger

    SiliaBond® Tosic Acid (SCX)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  7. SiliaBond® Tosyl Hydrazine

    SiliaBond® Tosyl Hydrazine

    SiliaBond® Tosyl Hydrazine (Si-TsNHNH2) is an effective scavenger of carbonyl compounds. It has been used to selectively remove aldehydes in the presence of ketones since the scavenging of ketones requires an acid catalyst. Once bound, sulfonyl hydrazones can be utilized in other synthetic transformations.

  8. SiliaBond® Maleimide

    SiliaBond® Maleimide

    SiliaBond® Maleimide (Si-MAL) has been designed to scavenge thiols. 90% of mercaptoethanol was removed with 4 eq. after 15 minutes in an aqueous environment. Complete scavenging was observed after 3 hours. SiliaBond Maleimide can also be used to immobilize peptides and proteins through the cysteine residues. 95% of L-cysteine was immobilized after only 15 minutes in a pH 4.5 buffered solution using 4 eq. of SiliaBond Maleimide.

  9. SiliaBond® Piperidine

    SiliaBond® Piperidine

    SiliaBond® Piperidine (Si-PIP) is a general purpose tertiary amine base to scavenge acids, thereby avoiding salt elimination problems. Also used as a base catalyst for Knoevenagel condensation.

  10. SiliaBond® DMAP

    SiliaBond® DMAP

    SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.

  11. SiliaBond Electrophile Introductory Scavenger Kit (K34230B) - Includes the following products: Amine - DMAP - Diamine - Tosyl Hydrazine - Piperazine - Triamine

    SiliaBond® Electrophile Introductory Scavenger Kit (K34230B)

    This kit includes the following products: Amine - DMAP - Diamine - Tosyl Hydrazine - Piperazine - Triamine
  12. SiliaMetS® Triamine

    SiliaMetS® Triamine

    SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.

  13. SiliaMetS® Diamine

    SiliaMetS® Diamine

    SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.

  14. SiliaMetS thiol metal scavenger - Best scavenger: Ag, Hg, Os, Pd & Ru - Good scavenger: Cu, Ir, Pb, Rh & Sn

    SiliaMetS® Thiol metal scavenger

    SiliaMetS Thiol is our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions.
  15. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  16. SiliaMetS Dimercaptotriazine (DMT) metal scavenger

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS DMT is the silica - bound equivalent of 2,4,6 - trimercaptotriazine (trithiocyanuric acid, TMT). It is a versatile metal scavenger for a variety of metals and the preferred metal scavenger for ruthenium catalysts and hindered Pd complexes (i.e. Pd(dppf)Cl2).
  17. SiliaBond® Diol

    SiliaBond® Diol

    SiliaBond Diol may also be used as polar sorbent in normal phase and aqueous size exclustion chromatography. Like bare silica, SiliaBond Diol has the ability to form hydrogen bonds and the capacity to separate structural isomers. Since most of its surface is covered with organic functions, the SiliaBond Diol absorbs less water, which leads to a more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water.

  18. SiliaBond® Propylsulfonic Acid (SCX-2)

    SiliaBond® Propylsulfonic Acid (SCX-2)

    Supported sulfonic acids such as SiliaBond® Propylsulfonic Acid (SiliaBond SCX-2) are in a class of strong acids widely used in different fields of synthetic organic chemistry. Their applications are well known and are used in a large number of settings going from drug discovery laboratories up to manufacturing processes. Among these applications, we denote their uses as acid catalysts, stationary phases for ion chromatography and basic impurity scavengers. Meanwhile, the most common use is probably as a strong cation exchanger (SCX) for the amine “Catch and Release” purification technique in SPE cartridges.

  19. SiliaBond® Carbonate

    SiliaBond® Carbonate

    SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.

  20. SiliaBond® TMA Acetate nec

    SiliaBond® TMA Acetate nec

    Strong anion exchangers (SAX) have been widely used in both chromatography and ion exchange SPE to selectively bind acidic drugs and/or analytes. In particular, weakly acidic compounds can be effectively extracted as those types of sorbents retain a permanent positive charge across the pH range. Most commercially available silica-based SAX sorbents are produced with a high selectivity chloride counter ion which reduced retention of acidic drugs when compared with lower selectivity counter ions such as acetate.

  21. SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (WCX)

    SiliaBond® Carboxylic Acid (Si-CAA) can be used as a scavenger for amines or carbonates, and for the quench of alkoxides and organometallic reagents. SiliaBond Carboxylic Acid is primarily used as a weak cation exchanger (WCX) in solid phase extraction (SPE) and in HPLC.

  22. SiliaBond® Guanidine (R68230B)

    SiliaBond® Guanidine (R68230B)

    SiliaBond®  Guanidine is a silica-supported diisopropylguanidine ligand.

  23. SiliaBond® Nucleophile Complete Scavenger Kit - includes the following products: Carbonate, Isocyanate, Maleimide, Tosyl Chloride

    SiliaBond® Nucleophile Complete Scavenger Kit: Carbonate, Isocyanate, Maleimide & Tosic Acid (K32630B)

    This kit includes the following products: Carbonate, Isocyanate, Maleimide, Tosyl Chloride
  24. SiliaBond Nucleophile Complete Scavenger Kit

    SiliaBond® Electrophile Complete Scavenger Kit (K35230B)

    This kit includes the following products: Amine - DEAM - Diol - DMAP - TMA Acetate - Triamine
  25. SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)

    SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)

    SiliaPrep Piperazine is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. By using this phase, elution can be done at a lower pH (around pH 8-9) comparatively to the SiliaPrep Amine.

  26. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep Diamine can be used in replacement of SAX for strong anions. It can also be employed as metal scavenger and in normal phase conditions.

  27. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  28. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  29. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  30. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  31. SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Diamine (PSA)

    SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Diamine (PSA)

    SiliaPrep double layer activated carbon/diamine cartridges are packed with pure graphitized carbon black stacked on the diamine phase.

  32. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and in normal phase conditions.

  33. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  34. SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Amine (WAX)

    SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Amine (WAX)

    SiliaPrep double layer activated carbon/amine cartridges are packed with pure graphitized carbon black stacked on the amine phase.

  35. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  36. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  37. SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid (SCX)

    SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  38. SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)

    SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.

  39. SiliaPrep™ 96 Well Plates Tosic Acid (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  40. SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)

    SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.

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