SiliaBond® - Functionalized Silica Gels
SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash® F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63µm, 60Å. We are able to provide all functionalized products on any silica of this catalog (SiliaFlash, IMPAQ™, SiliaSphere™ & SiliaSphere™ PC) in any format (SiliaPrep™ SPE and SiliaSep™, SiliaSep, etc.) on a custom basis.More Information
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Advantages of Functionalized Silica over Polymers
Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
Easily Scalable: Works on the microgram to the multi-ton scale.
Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
Controlled Loading: Consistent and accurate loading (lot-to-lot).
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography) or
a) SiliaBond Chromatographic Stationary Phases
b) SiliaBond Fluorous Phases
c) SiliaBond Ion Exchangers
2. As tools in organic synthesis.
a) SiliaBond Acids
b) SiliaBond Bases
c) SiliaBond Oxidants
d) SiliaBond Reagents
e) SiliaBond Scavengers
i. SiliaBond Electrophile Scavengers
ii. SiliaBond Metal Scavengers
iii. SiliaBond Nucleophile Scavengers
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
27 Item(s)
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Carboxylic Acid (WCX)
SiliaPrep Carboxilic Acid is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
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SiliaPrep™ SPE Cartridges Carboxylic Acid nec (WCX)
SiliaPrep Carboxilic Acid nec is a weak cation exchanger sorbent (WCX) used to extract strong basics compounds.
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SiliaPrep™ SPE Cartridges Piperazine (SPE-R60030B)
SiliaPrep Piperazine is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. By using this phase, elution can be done at a lower pH (around pH 8-9) comparatively to the SiliaPrep Amine.
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SiliaPrep™ SPE Cartridges Diethylamine (WAX-2)
SiliaPrep Diethylamine (WAX-2) is a weak anion exchanger that can be used in replacement of SAX and SAX-2 for strong anions to avoid irreversible retention. This phase presents a slightly lower capacity and a moderate non polar character due to the alkyl chain on the amino function. Moreover, it can be employed as metal scavenger and in normal phase conditions.
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SiliaPrep™ SPE Cartridges TMA Chloride nec (SAX)
SiliaPrep TMA Chloride (SAX) is a strong anion exchanger sorbent positively charged under all conditions used to extract acid molecules (pKa 3-5).
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SiliaPrep™ SPE Cartridges TMA Acetate nec
SiliaPrep TMA Acetate (SAX-2) is a strong anion exchanger sorbent with a low selectivity acetate counter ion already in place. This sorbent retains more favorably acidic compounds with pKas <5, such as carboxylic acid.
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SiliaPrep™ SPE Cartridges Tosic Acid (SCX)
SiliaPrep Tosic Acid (SCX) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Tosic Acid nec (SCX)
SiliaPrep Tosic Acid is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid (SCX-2)
SiliaPrep Propylsulfonic Acid (SCX-2) is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Propylsulfonic Acid nec (SCX-2)
SiliaPrep Propylsulfonic Acid nec is a strong cation exchanger and maintains a negative charge throughtout the pH scale. The most common use is a strong cation exchanger for the amine and basics molecules "catch and release" purification technique in SPE cartridges.
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SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Thiol
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges TAAcOH
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges Cyano
SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.
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SiliaPrep™ SPE Cartridges Cyano nec
SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.
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SiliaPrep™ SPE Cartridges Diol
SiliaPrep Diol nec is a moderate polar sorbent presenting neutral character used to extract polar compounds from non-polar solvents, structural isomers. Alternative to silica when the acidic character is problematic.
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SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Carbodiimide (DCC)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Pentafluoprophenyl
SiliaPrep Pentafluorophenyl is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones. The electron density presents fluorinated aromatic ring which affords an enhancement in the retention of conjugated and aromatic ring-containing due to the desirable pi-pi interactions. Excellent alternative of the C18 when the C18 presents a selectivity problem.
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SiliaPrep™ SPE Cartridges Fluorochrom
SiliaPrep Fluorochrom is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.
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SiliaPrep™ SPE Cartridges Tridecafluoro
SiliaPrep Tridecafluoro is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.
27 Item(s)
List Grid
- Metal to Remove
- Family / Formats
- Phases
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- Amine (2)
- Carbodiimide (DCC) (1)
- Carbonate (1)
- Carboxylic Acid (WCX) (2)
- Cyano (2)
- Diamine (2)
- Dichlorotriazine (DCT) (1)
- Diethylamine (WAX-2) (1)
- Dimercaptotriazine (DMT) (1)
- Diol (1)
- Fluorochrom (1)
- Pentafluorophenyl (1)
- Piperazine (1)
- Propylsulfonic Acid (SCX-2) (2)
- TAAcOH (1)
- Thiol (1)
- TMA Acetate (1)
- TMA Chloride (SAX) (1)
- Tosic Acid (SCX) (2)
- Triamine (1)
- Tridecafluoro (1)
- Pore Size
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- 60 Å (27)
- Endcapping
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- Endcapped (27)
- Non-endcapped (6)
- Cartridges Volume
- Particle Size
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