SiliaBond® - Functionalized Silica Gels
SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash® F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63µm, 60Å. We are able to provide all functionalized products on any silica of this catalog (SiliaFlash, IMPAQ™, SiliaSphere™ & SiliaSphere™ PC) in any format (SiliaPrep™ SPE and SiliaSep™, SiliaSep, etc.) on a custom basis.More Information
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Advantages of Functionalized Silica over Polymers
Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
Easily Scalable: Works on the microgram to the multi-ton scale.
Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
Controlled Loading: Consistent and accurate loading (lot-to-lot).
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography) or
a) SiliaBond Chromatographic Stationary Phases
b) SiliaBond Fluorous Phases
c) SiliaBond Ion Exchangers
2. As tools in organic synthesis.
a) SiliaBond Acids
b) SiliaBond Bases
c) SiliaBond Oxidants
d) SiliaBond Reagents
e) SiliaBond Scavengers
i. SiliaBond Electrophile Scavengers
ii. SiliaBond Metal Scavengers
iii. SiliaBond Nucleophile Scavengers
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
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SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Diamine (PSA)
SiliaPrep double layer activated carbon/diamine cartridges are packed with pure graphitized carbon black stacked on the diamine phase.
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SiliaPrep™ 96 Well Plates Amine
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Amine nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Carboxylic Acid (WCX) nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Diethylamine (WAX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates TMA Chloride nec (SAX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates TMA Acetate nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Tosic Acid (SCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Tosic Acid nec (SCX)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Propylsulfonic Acid nec (SCX-2)
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaBond® C18 (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.
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SiliaBond® C18 nec (23%)
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.
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SiliaBond® C18 (17%)
The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.
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SiliaBond® C18 (17%) Polymeric
The homogeneous coverage of the polymeric C18 ensures great separation for hydrophobic compounds with lot-to-lot high reproducibility and inhibits the non-specific interaction with residual silanols. The SiliaBond Polymeric C18 (17%) is the traditional matrix for reversed-phase chromatography. Considered as the least selective phase since it interacts with wide range of organics and biological molecules.
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SiliaBond® C18 nec (17%)
This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions. The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.
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SiliaBond® C18 (11%)
SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.
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SiliaBond® C8
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® C8 nec
SiliaBond® C8 (or C8) is a reversed-phase matrix with a moderate degree of hydrophobicity that works well for separating a wide range of compounds. It can be used instead of C18 when shorter retention times are desired.
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SiliaBond® C1
SiliaBond® C1 (or C1) has the lowest degree of hydrophobicity of all reversed stationary phases, useful in the separation of large biomolecules that have extensive hydrophobic regions.
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SiliaBond® Phenyl
SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.
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SiliaBond® Phenyl nec
SiliaBond® Phenyl (Si-PHE) is a sorbent of medium polarity used in reversed-phase chromatography. It has similar retention than C8 but with different selectivity especially for molecules containing aromatics and fatty acids.
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SiliaBond® C12 (Adamantyl)
SiliaBond® C12 (or C12, Si-Adamantyl) has a polarity similar to C18 with additional steric bulk to provide additional separation characteristics.
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SiliaBond® Cyclohexyl
SiliaBond® Cyclohexyl (Si-CYH) is a sorbent of medium polarity used in reversed-phase chromatography. It has a different selectivity than the alkyl sorbents (C18, C8, C4, …) and phenyl, and may be used when these fail to provide the desired selectivity.
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SiliaBond® Reversed-Phase Kit
C8 monomeric - C18 (17%) polymeric - C18 (17%) monomeric - C18 (23%) - Cyano - Phenyl -
SiliaBond® Glycidoxy
SiliaBond® Glycidoxy (Si-GLY) may be used as a linker for further modification of the surface and for the immobilization of molecules bearing amino, hydroxy, mercapto and thiocarboxylic acid groups.
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SiliaBond® Pyridine
SiliaBond Pyridine (Si-PYR) can be used as a tertiary amine for acid removal. It can also anchor Cu2+ ions and then be used as a catalyst for hydroquinone oxidation.
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SiliaBond® Dimethylamine
SiliaBond® Dimethylamine is a silica bound tertiary amine base that can be used in most applications requiring a tertiary amine, particularly as a HCl sponge. Silica bound ammonium salt by-products are easily separated by filtration. This dimethylamine immobilized on silica gel can be used as a base catalyst in Michael or Knoevenagel reactions.
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SiliaBond® Allyl
SiliaBond® Allyl (Si-Allyl) can be used as solid support for further derivatization.
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SiliaBond® Bromophenyl
SiliaBond® Bromophenyl (Si-BRP) can be used as solid support for further derivatization.
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SiliaBond® Propyl Bromide
SiliaBond® Propyl Bromide (Si-PBR) is a versatile solid support for amines and alcohols. It is more reactive than the chloride towards displacement.
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SiliaBond® Phenylmethylchloride
SiliaBond® Phenylmethylchloride (Si-PMC) can be used as solid support for further derivatization.
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SiliaBond® Carbonate
SiliaBond® Carbonate (Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaBond® Morpholine
SiliaBond® Morpholine (Si-MOR) is commonly used as an acid sponge. It is used in the same manner as morpholine functionalized polymers.
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SiliaBond® DMAP
SiliaBond® DMAP (Si-DMAP) is the supported equivalent of 4-dimethylaminopyridine commonly used as a nucleophilic catalyst in a wide variety of reactions such as acylation, amidation or acetylation.
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SiliaBond® Base Kit
Amine - Carbonate - Dimethylamine - Diethylamine - Morpholine - Pyridine - TBD -
SiliaBond® TBD
SiliaBond® TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene, Si-TBD) is a silica bound bicyclic guanidine moiety that is sufficiently basic to deprotonate moderately acidic hydrogens. It is most commonly used for the alkylation of phenols (Williamson ether synthesis) and amines, and the esterification of carboxylic acids using alkyl halides. It may also be used to scavenge boronic acids such as phenylboronic acid: 98% removal with 1 equivalent in DCM at room temperature after 1 h.
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SiliaMetS® Imidazole
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
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SiliaBond® Silver Nitrate (AgNO3) nec
Chromatography with silver nitrate is a well known and established methodology for the separation of non polar compounds with similar polarities. Generally, with a mixture of unsaturated compounds such as alkenes, lipids, steroids, terpenes, etc, standard separation procedures lack in efficiency. However, by using SiliaBond® Silver Nitrate for your column chromatography along with SiliaPlate™ Ag for your TLC, you will have the necessary tools to circumvent the problem.
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SiliaBond® C4
SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules. It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.
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SiliaBond® C4 nec
SiliaBond® C4 (or C4) provides less retention towards non-polar compounds than C18 and C8, and is useful in ion-pairing chromatography or to separate large biomolecules. It works best for molecules with a large hydrophilic region or in case where the hydrophobic region is buried within the structure.
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SiliaBond® Diol
SiliaBond Diol may also be used as polar sorbent in normal phase and aqueous size exclustion chromatography. Like bare silica, SiliaBond Diol has the ability to form hydrogen bonds and the capacity to separate structural isomers. Since most of its surface is covered with organic functions, the SiliaBond Diol absorbs less water, which leads to a more reproducible activity. It is also the sorbent of choice when working in normal phase in the presence of water.
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SiliaBond® Cyano
SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.
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SiliaBond® Cyano nec
SiliaBond® Cyano (Si-CN) can be used both in normal and reversed-phase chromatography as its polarity marks the separation between the polar and non-polar phases. SiliaBond Cyano is the least retentive polar sorbent in normal phase chromatography and the least retentive of the non-polar sorbents in reversed-phase chromatography.
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SiliaBond® Diphenylphosphine
SiliaBond® Diphenylphosphine (Si-DPP) can be used as linker for catalyst immobilization such as tetrakis-(triphenylphosphine)palladium(0) for Suzuki coupling.
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SiliaBond® Tosyl Chloride
SiliaBond® Tosyl Chloride (Si-TsCl) readily reacts with nucleophiles such as amines and alcohols. Reaction with alcohols yields the bound tosylate, which can then be used to synthesize amines and oxazolines.
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SiliaBond® Isocyanate
SiliaBond® Isocyanate (Si-ISO) is a versatile scavenger for nucleophiles. It readily scavenges amines, thiols, thiolates, alkoxides, and acidic phenols. Loading is determined by the removal of benzylamine in hexane at room temperature.
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SiliaBond® Dichlorotriazine (DCT)
Amide bond formation is certainly among the most common chemical transformation in organic synthesis. This explains the diversity of possible reaction pathways and reagents available on the market. SiliCycle is part of this trend and this is why we have developed the bound equivalent of 2,4,6-trichloro-1,3,5-triazine(cyanuric chloride), SiliaBond® Dichlorotriazine (Si-DCT).
- Metal to Remove
- Family / Formats
- Phases
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- Activated Carbon/Amine (WAX) (1)
- Activated Carbon/Diamine (PSA) (1)
- Allyl (1)
- Aluminum Chloride (1)
- Amine (8)
- Bromophenyl (1)
- BTMA Chloride (1)
- C1 (1)
- C12 (2)
- C18 (7)
- C2 (2)
- C4 (3)
- C8 (3)
- Carbodiimide (DCC) (3)
- Carbonate (4)
- Carboxylic Acid (WCX) (6)
- Cyano (7)
- Cyanoborohydride (2)
- Cyclohexyl (1)
- Cyclohexyldiol (1)
- Cysteine (2)
- Diamine (4)
- Dichlorotriazine (DCT) (3)
- Diethylamine (2)
- Diethylamine (WAX-2) (2)
- Dimercaptotriazine (DMT) (3)
- Dimethylamine (2)
- Diol (3)
- Diphenylphosphine (1)
- DMAP (3)
- Ethyl Carbodiimide (EDC) (2)
- Fluorochrom (3)
- Glycidoxy (1)
- HOBt (1)
- Imidazole (2)
- Isocyanate (2)
- Maleimide (1)
- Morpholine (2)
- Pentafluorophenyl (3)
- Phenyl (3)
- Phenylmethylchloride (1)
- Piperazine (3)
- Piperidine (1)
- Potassium Permanganate (2)
- Propyl Bromide (1)
- Propyl Chloride (1)
- Propylsulfonic Acid (SCX-2) (7)
- Pyridine (2)
- Pyridinium Chlorochromate (PCC) (2)
- Pyridinium Dichromate (PDC) (2)
- SAX (1)
- SCX (1)
- SCX-2 (1)
- Silver Nitrate (AgNO3) (1)
- TAAcOH (4)
- TAAcONa (2)
- TBA Chloride (1)
- TBD (2)
- TEMPO (1)
- Thiol (3)
- Thiourea (2)
- TMA Acetate (4)
- TMA Chloride (SAX) (4)
- Tosic Acid (SCX) (8)
- Tosyl Chloride (2)
- Tosyl Hydrazine (2)
- Triamine (4)
- Tridecafluoro (3)
- Urea (1)
- WAX (1)
- WCX (1)
- Pore Size
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- 60 Å (121)
- Endcapping
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- Endcapped (132)
- Non-endcapped (21)
- Cartridges Volume
- Bed Weight
- Particle Size
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- 40-63 µm / 230-400 mesh (121)
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