SiliaBond® - Functionalized Silica Gels
SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash® F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63µm, 60Å. We are able to provide all functionalized products on any silica of this catalog (SiliaFlash, IMPAQ™, SiliaSphere™ & SiliaSphere™ PC) in any format (SiliaPrep™ SPE and SiliaSep™, SiliaSep, etc.) on a custom basis.More Information
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Advantages of Functionalized Silica over Polymers
Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
Easily Scalable: Works on the microgram to the multi-ton scale.
Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
Controlled Loading: Consistent and accurate loading (lot-to-lot).
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography) or
a) SiliaBond Chromatographic Stationary Phases
b) SiliaBond Fluorous Phases
c) SiliaBond Ion Exchangers
2. As tools in organic synthesis.
a) SiliaBond Acids
b) SiliaBond Bases
c) SiliaBond Oxidants
d) SiliaBond Reagents
e) SiliaBond Scavengers
i. SiliaBond Electrophile Scavengers
ii. SiliaBond Metal Scavengers
iii. SiliaBond Nucleophile Scavengers
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
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SiliaBond® Tridecafluoro
SiliaBond® Tridecafluoro (Si-TDF) is a sorbent primarily used to separate fluorinated molecules. It can also be used in fluorous solid-phase extraction (FSPE) of fluorous-tag compounds as reported for the synthesis of oligosaccharide.
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SiliaBond® Fluorochrom
SiliaBond® Fluorochrom (Si-FCM) is a fluorinated sorbent particularly useful for the separation of fluorine containing molecules from non-fluorous ones. The applications of these types of sorbent are not limited to fluorous compounds but may also be used in chromatographic separation of non-fluorinated molecules, just like a regular reversed-phase would do, but with different selectivity. SiliaBond Fluorochrom presents the highest level of fluorine available and has a proprietary structure.
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SiliaBond® Cyanoborohydride
SiliaBond® Cyanoborohydride (Si-CBH) is the silica bound equivalent of sodium cyanoborohydride. Bound cyanoborohydride is very useful in reductive amination and in the reduction of imines and aldehydes. This problem is minimized with the use of silica bound materials since the toxic cyanide residue remains on the silica.
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SiliaBond® Urea
SiliaBond® Urea (Si-Urea) can be used for cationic surfactants adsorbtion and as polar stationary phase for chromatography.
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SiliaBond® Pentafluorophenyl
SiliaBond® Pentafluorophenyl (Si-PFP) is a sorbent primarily used in the separation of molecules bearing fluorine atoms but may also be used in the separation of non-fluorous compounds such as Taxol® and its derivatives. Because of its phenyl ring, Si-PFP has a higher selectivity for aromatics containing molecules compared to the other fluorinated sorbents.
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SiliaBond® Carbodiimide (DCC)
SiliaBond® Carbodiimide (Si-DCC) is a bound neutral carbodiimide that may be used for the synthesis of amides, esters, and activated esters.
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SiliaBond® Ethyl Carbodiimide (EDC)
SiliaBond® Ethyl-Dimethylaminopropyl Carbodiimide (Si-EDC) reacts in a similar fashion to SiliaBond Carbodiimide (Si-DCC). The advantage of Si-EDC is this new reagent greatly simplifies the work up procedure of the reactions since a simple filtration is all that takes to remove the unwanted side product of the amides formation (urea).
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SiliaBond® Maleimide
SiliaBond® Maleimide (Si-MAL) has been designed to scavenge thiols. 90% of mercaptoethanol was removed with 4 eq. after 15 minutes in an aqueous environment. Complete scavenging was observed after 3 hours. SiliaBond Maleimide can also be used to immobilize peptides and proteins through the cysteine residues. 95% of L-cysteine was immobilized after only 15 minutes in a pH 4.5 buffered solution using 4 eq. of SiliaBond Maleimide.
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SiliaBond® Aluminum Chloride
SiliaBond® Aluminium Chloride (Si-AlClx) is the silica supported version of the most widely used Lewis acid, aluminium chloride. It is an effective catalyst for Friedel-Crafts alkylations and acylations. It also catalyzes the formation of ethers.
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SiliaMetS® Metal Scavenger Kit
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea -
SiliaBond® Nucleophile Scavenger Kit
Isocyanate - Tosic Acid - Tosyl Chloride -
SiliaBond® Reagent Kit
Carbodiimide - Cyanoborohydride - Dichlorotriazine - DMAP - EDC - HOBt -
SiliaBond® Ion Exchanger Kit
WAX - WCX -SCX-2 -SCX -SAX - TMA Acetate -
SiliaBond® Electrophile Scavenger Kit
Amine - Diamine - Triamine - DMAP - Piperazine - Tosyl Hydrazine -
SiliaPrep™ SPE Cartridges Cyano
SiliaPrep Cyano is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to extract acidic, neutral, basic compounds from aqueous solutions.
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SiliaPrep™ SPE Cartridges Cyano nec
SiliaPrep Cyano nec is a moderate polar sorbent used as reversed-phase (less hydrophobic than C18 and C8 phases) and normal phase (less polar compared to silica) to ectract acidic, neutral, basic compounds from aqueous solutions.
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SiliaPrep™ SPE Cartridges Diol
SiliaPrep Diol nec is a moderate polar sorbent presenting neutral character used to extract polar compounds from non-polar solvents, structural isomers. Alternative to silica when the acidic character is problematic.
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SiliaPrep™ SPE Cartridges Carbonate
SiliaPrep Carbonate (or Si-CO3) is the silica bound equivalent of tetramethyl ammonium carbonate. It can be used as a general base to quench a reaction, to free base amines in their ammonium salt form and to scavenge acids, boronic acids and acidic phenols, including HOBt, which is widely used in amide coupling reactions.
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SiliaPrep™ SPE Cartridges Carbodiimide (DCC)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges Dichlorotriazine (DCT)
SiliaPrep Dichlorotriazine has been designed as a reagent for amide coupling applications.
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SiliaPrep™ SPE Cartridges - Double Layer Activated Carbon/Amine (WAX)
SiliaPrep double layer activated carbon/amine cartridges are packed with pure graphitized carbon black stacked on the amine phase.
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SiliaPrep™ 96 Well Plates Carbonate
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Cyano
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Cyano nec
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Diol
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ SPE Cartridges Pentafluoprophenyl
SiliaPrep Pentafluorophenyl is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones. The electron density presents fluorinated aromatic ring which affords an enhancement in the retention of conjugated and aromatic ring-containing due to the desirable pi-pi interactions. Excellent alternative of the C18 when the C18 presents a selectivity problem.
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SiliaPrep™ SPE Cartridges Fluorochrom
SiliaPrep Fluorochrom is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.
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SiliaPrep™ SPE Cartridges Tridecafluoro
SiliaPrep Tridecafluoro is a fluorous sorbent used to separate fluorinated molecules and non-fluorinated ones.
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SiliaPrep™ 96 Well Plates Pentafluorophenyl
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Fluorochrom
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates Tridecafluoro
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
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SiliaPrep™ 96 Well Plates SCX-2/SAX
Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
- Metal to Remove
- Family / Formats
- Phases
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- Activated Carbon/Amine (WAX) (1)
- Activated Carbon/Diamine (PSA) (1)
- Allyl (1)
- Aluminum Chloride (1)
- Amine (8)
- Bromophenyl (1)
- BTMA Chloride (1)
- C1 (1)
- C12 (2)
- C18 (7)
- C2 (2)
- C4 (3)
- C8 (3)
- Carbodiimide (DCC) (3)
- Carbonate (4)
- Carboxylic Acid (WCX) (6)
- Cyano (7)
- Cyanoborohydride (2)
- Cyclohexyl (1)
- Cyclohexyldiol (1)
- Cysteine (2)
- Diamine (4)
- Dichlorotriazine (DCT) (3)
- Diethylamine (2)
- Diethylamine (WAX-2) (2)
- Dimercaptotriazine (DMT) (3)
- Dimethylamine (2)
- Diol (3)
- Diphenylphosphine (1)
- DMAP (3)
- Ethyl Carbodiimide (EDC) (2)
- Fluorochrom (3)
- Glycidoxy (1)
- HOBt (1)
- Imidazole (2)
- Isocyanate (2)
- Maleimide (1)
- Morpholine (2)
- Pentafluorophenyl (3)
- Phenyl (3)
- Phenylmethylchloride (1)
- Piperazine (3)
- Piperidine (1)
- Potassium Permanganate (2)
- Propyl Bromide (1)
- Propyl Chloride (1)
- Propylsulfonic Acid (SCX-2) (7)
- Pyridine (2)
- Pyridinium Chlorochromate (PCC) (2)
- Pyridinium Dichromate (PDC) (2)
- SAX (1)
- SCX (1)
- SCX-2 (1)
- Silver Nitrate (AgNO3) (1)
- TAAcOH (4)
- TAAcONa (2)
- TBA Chloride (1)
- TBD (2)
- TEMPO (1)
- Thiol (3)
- Thiourea (2)
- TMA Acetate (4)
- TMA Chloride (SAX) (4)
- Tosic Acid (SCX) (8)
- Tosyl Chloride (2)
- Tosyl Hydrazine (2)
- Triamine (4)
- Tridecafluoro (3)
- Urea (1)
- WAX (1)
- WCX (1)
- Pore Size
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- 60 Å (120)
- Endcapping
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- Endcapped (123)
- Non-endcapped (21)
- Cartridges Volume
- Bed Weight
- Particle Size
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- 40-63 µm / 230-400 mesh (120)
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