SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash® F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63µm, 60Å. We are able to provide all functionalized products on any silica of this catalog (SiliaFlash, IMPAQ™, SiliaSphere™ & SiliaSphere™ PC) in any format (SiliaPrep™ SPE and SiliaSep™, SiliaSep, etc.) on a custom basis.More Information
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
Easily Scalable: Works on the microgram to the multi-ton scale.
Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
Controlled Loading: Consistent and accurate loading (lot-to-lot).
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography) or
a) SiliaBond Chromatographic Stationary Phases
b) SiliaBond Fluorous Phases
c) SiliaBond Ion Exchangers
2. As tools in organic synthesis.
a) SiliaBond Acids
b) SiliaBond Bases
c) SiliaBond Oxidants
d) SiliaBond Reagents
e) SiliaBond Scavengers
i. SiliaBond Electrophile Scavengers
ii. SiliaBond Metal Scavengers
iii. SiliaBond Nucleophile Scavengers
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules.
SiliaBond® C18 (or C18) is the traditional matrix for reversed-phase chromatography. The high loading provides the highest degree of hydrophobicity commercially available. Considered as the least selective phase since it interacts with a wide range of organic molecules. Also used in ion-pairing chromatography (non-endcapped) for the separation of biomolecules.
The SiliaBond® C18 17% BDS is the most efficient deactivated C18 reversed-phase. This versatile support is the best choice for your applications in reversed-phase chromatography. This chromatographic phase has been compared with different competitors and presents a better separation for basic compounds.
This non-endcapped version of the SiliaBond® C18 17% BDS, presents a perfect monolayer of dimethyloctadecylsilane and silanol functions. The hydrophilic/hydrophobic balance is permitting to use a mobile phase with a higher concentration of water and ion pairing conditions for separation of biomolecules.
SiliaBond® C18 11% is used as a reversed-phase chromatographic matrix when large hydrophobic molecules are too strongly retained on SiliaBond C18 with higher carbon content.
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids and various compounds from water, foods & beverages. Presence of free silanols allows secondary interactions for the extraction of basic compounds.
SiliaPrep C18 is a non-polar sorbent used to extract acidic, neutral and acidic compounds from aqueous solutions, various organic compounds from water as well as drugs & metabolites from physiological fluids.
SiliaPrep C18 nec is a non-polar sorbent similar to SiliaPrep C18 but presents higher retention and polar selectivity for basic compounds. Unreacted surface OH's can be used for soft condition of catch and release purification of glucoronides for example.
SiliaPrep C18 (11%) is a non-polar sorbent used to elute very large hydrophobic molecules that are too strongly retained on higher carbon loading.
Collapse All | Expend All
We proudly Launch our New SiliCycle Catalog for the Pharmaceutical Industry
Get your free hard copy NOW!
To order your free hard copy, please click here and register first...
