SiliaBond® - Functionalized Silica Gels
SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis. The backbone of all SiliaBond products is SiliCycle SiliaFlash® F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63µm, 60Å. We are able to provide all functionalized products on any silica of this catalog (SiliaFlash, IMPAQ™, SiliaSphere™ & SiliaSphere™ PC) in any format (SiliaPrep™ SPE and SiliaSep™, SiliaSep, etc.) on a custom basis.More Information
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Advantages of Functionalized Silica over Polymers
Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
Easily Scalable: Works on the microgram to the multi-ton scale.
Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
Controlled Loading: Consistent and accurate loading (lot-to-lot).
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography) or
a) SiliaBond Chromatographic Stationary Phases
b) SiliaBond Fluorous Phases
c) SiliaBond Ion Exchangers
2. As tools in organic synthesis.
a) SiliaBond Acids
b) SiliaBond Bases
c) SiliaBond Oxidants
d) SiliaBond Reagents
e) SiliaBond Scavengers
i. SiliaBond Electrophile Scavengers
ii. SiliaBond Metal Scavengers
iii. SiliaBond Nucleophile Scavengers
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
8 Item(s)
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SiliaMetS® TAAcONa
SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.
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SiliaMetS® Cysteine
SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaMetS® TAAcOH
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges TAAcOH
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
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SiliaMetS® Imidazole
SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.
SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.
8 Item(s)
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- Metal to Remove
- Family / Formats
- Phases
- Pore Size
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- 60 Å (8)
- Endcapping
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- Endcapped (6)
- Non-endcapped (3)
- Cartridges Volume
- Bed Weight
- Particle Size
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