SiliaBond ® Functionalized Silica Gels
SiliCycle is the leader in the development of functionalized silica gels, gathered under the name SiliaBond, for use in organic synthesis.
Functionalized Silica Portfolio
Acids, Bases, Linkers Chromatographic Phases Reagents for Organic Synthesis
Organic Scavengers Metal Scavengers
The backbone of all SiliaBond products is SiliCycle SiliaFlash F60 which provides superior performance for all types of applications due to the narrow particle size distribution and high purity. All the products in this section are made of standard flash silica gel, namely 40-63 µm, 60 Å.
We are able to provide functionalized products based on any of our silicas (SiliaFlash, SiliaSphere & SiliaSphere PC) in any format (SiliaPrep SPE and SiliaSep Flash cartridges, etc.) on a custom basis.
The use of solid supported reagents and scavengers is an excellent way to expedite organic synthesis by simplifying the purification process. Standard purification procedures including chromatography, liquid-liquid extraction, and crystallization can be time-consuming and difficult to scale up. In many cases, supported reagents have distinct advantages over their solution-phase counterparts, the biggest one being the ability to do multiple transformations in a single pot, the immobilization of toxic reagents, and increased selectivity. They are suitable for use in batch reactions and in flow through applications.
Advantages of Functionalized Silica over Polymers
- Fast Kinetics: Since the silica is surface functionalized, the rate of reaction is not controlled by the diffusion in and out of the polymer. Most of our scavengers work under an hour.
- Solvent Independent: Silica neither shrinks nor swells in any solvent and because it is endcapped, it will not dissolve in any solvent. The SiliaBond does not dictate the solvent of your reaction.
- Easy to Use: Easy to weigh and handle since silica does not carry a static charge and is always free flowing. Its high density makes it suitable for small volume work. It does not require extensive -washing for high recoveries and will not stick to glassware. It is amenable to automation.
- Mechanically Stable: Works well with overhead stirring and can be used with a bottom coupled spin bar for up to four hours.
- Thermally Stable: Most SiliaBond can withstand temperatures of over 200°C and are suitable for use in microwave synthesizers.
- Easily Scalable: Works on the microgram to the multi-ton scale.
- Flexible Formats: Because it does not swell, silica gel can be packed into a variety of flow through formats such as HPLC columns, flash and SPE cartridges, and 96 well plates.
- Controlled Loading: Consistent and accurate loading (lot-to-lot).
Application domains
The application domains of the SiliaBond are mainly divided in two:
1. They are either for the separation of mixtures in their individual components (chromatography)
2. As tools in organic synthesis.
For your convenience, we have combined our most popular scavengers and reagents for the most common applications into SiliaBond Kits so you can be prepared with material in hand for any application.
Application Notes
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