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SiliaBond Metal Scavengers

Metal Scavengers - SiliaMetS®

SiliCycle, THE leader in metal scavenging solutions! Why choose SiliCycle?

 

What are SiliaMetS Metal Scavengers?

What is a Metal Scavenger

SiliaMetS Metal Scavengers are functionalized silica gels designed to react and bind excess metal complexes. The process for using scavengers is outlined in the scheme

To be effective, the Metal Scavengers need the ability and inherent functionality to remove metals in their various oxidation states from the reaction mixture. For example, upon completion of a palladium metal-catalyzed reaction, the metal residue contained in the reaction can exist in both Pd(0) and Pd(II).

 

 

SiliaMetS - For Metal Removal

In recent years, the time pressure associated with quickly bringing candidate drugs to market has increased the number of transition metal-catalyzed reactions being transferred from lead optimization to early scale-up. The removal of post-reactions metal residues has become a major issue in the pharmaceutical industry. Purification of APIs from residual metal catalyst by traditional methods (chromatography, activated carbon, distillation, etc.) often leads to problems such as high costs, time loss, low efficiency, and reduced API yields. To overcome these limitations, SiliCycle has developed SiliaMetS Metal Scavengers, a range of products that have significantly changed how chemists can purify APIs.

Silica-based metal scavengers have been proven to be the purification method of choice over all other methods and several companies from various industries use them. Take a look at the section “Customers Successful Stories with SiliaMetS” to read about satisfied customers. With the silica matrix advantages over polymers (no swelling, more general solvent compatibility, higher mechanical and thermal stabilities, applications easily scalables and products available in different formats (SPE, flash cartridges and bulk), etc.) combined to SiliCycle’ expertise in grafting technology, SiliaMetS are the solution for metal removal without contamination of drug candidates. SiliaMetS are highly selective and offer a cost-effective alternative for metal scavenging.

 

SiliaMetS - Regulatory Information

For many years, SiliaMetS Metal Scavengers are used on pilot plan by GMP pharmaceutical, biotechnology, and fine chemical industries as well as contract research and manufacturing organizations. They have run their own analysis proving SiliaMetS Metal Scavengers can safely be used without compromising the purity of the material by leaching of the silica-supported product.

Thus, SiliCycle is committed to high quality standards and always wants to provide default free products. In doing so, all products are manufactured in an ISO9001:2008 compliant facility and submitted to a stringent quality control. Every lot needs to meet the quality specifications to be released and a sample from every batch is kept for subsequent analysis.

Need specific regulatory files? SiliCycle can work with you to fill your requirements and provide you custom regulatory documentations that will include specific analytical tests in line with your needs.

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  1. SiliaMetS thiol metal scavenger - Best scavenger: Ag, Hg, Os, Pd & Ru - Good scavenger: Cu, Ir, Pb, Rh & Sn

    SiliaMetS® Thiol metal scavenger

    SiliaMetS Thiol is our most versatile and robust metal scavenger for a variety of metals under a wide range of conditions.
  2. SiliaMetS Dimercaptotriazine (DMT) metal scavenger

    SiliaMetS® Dimercaptotriazine (DMT)

    SiliaMetS DMT is the silica - bound equivalent of 2,4,6 - trimercaptotriazine (trithiocyanuric acid, TMT). It is a versatile metal scavenger for a variety of metals and the preferred metal scavenger for ruthenium catalysts and hindered Pd complexes (i.e. Pd(dppf)Cl2).
  3. SiliaBond® Amine

    SiliaBond® Amine

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  4. SiliaMetS® Diamine

    SiliaMetS® Diamine

    SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.

  5. SiliaMetS® Triamine

    SiliaMetS® Triamine

    SiliaMetS® Triamine (SiliaMetS WAX-3, Si-TRI) is effective for scavenging metals such as Pb, Co, Ru and Pd. Our screening studies have shown it to be the preferred scavenger for Pb. It can also be used as a scavenger for acid chlorides, isocyanates and other electrophiles.

  6. SiliaMetS® AMPA

    SiliaMetS® AMPA

    SiliaMetS AMPA is an aminomethylphosphonic acid ligand known for its excellent metal-bonding properties. It is particularly efficient to remove Aluminium, Antimony, Nickel, Lanthanides, and also very effective for Cobalt, Iron, Manganese and Zinc scavenging from reaction intermediates or final APIs. 

  7. SiliaMetS® Cysteine

    SiliaMetS® Cysteine

    SiliaMetS® Cysteine (Si-Cys) is the silica bound equivalent of the amino acid Cysteine. By attaching the molecule to the backbone via the amino group, the thiol group remains free and accessible for higher metal scavenging efficiency. It is a versatile metal scavenger for a variety of metals including Pd, Sn, Ru, Pt, Cu, Rh, Cd and Sc under a wide range of conditions and the preferred metal scavenger for tin residues.

  8. SiliaMetS® DEAM

    SiliaMetS® DEAM

    SiliaMetS DEAM is a versatile scavenger designed to remove trace metal or boronic acids from reaction intermediates or final APIs. 

  9. SiliaMetS DOTA

    SiliaMetS DOTA

    SiliaMetS DOTA is a silica-supported tetracarboxylic acid and its various conjugate bases. DOTA molecule is a well-adopted complexing agent. Linked to various metals, so formed-complexes are used as contrast agents in cancer treatments or other medical applications.
  10. SiliaMetS® Imidazole

    SiliaMetS® Imidazole

    SiliaMetS® Imidazole (Si-IMI) is a versatile metal scavenger for a variety of metals including Cd, Co, Cu, Fe, Ni, Pd, and Rh under a wide range of conditions and the preferred metal scavenger for iron catalysts.

    SiliaMetS Imidazole can also be used as an amine base in systems that are generally sensitive to basic conditions compared to other SiliaMetS supported bases.

  11. SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH

    SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).

  12. SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa

    SiliaMetS® TAAcONa or (or SiliaMetS Triaminetetraacetate, sodium salt) is a silica bound metal scavenger for Pd(II), Ni(II) and Cu. It is the supported version of EDTA in its sodium salt form. It is an effective scavenger for metals in higher oxidation state, 2+ or higher.

  13. SiliaMetS® Thiourea

    SiliaMetS® Thiourea

    SiliaMetS® Thiourea (Si-THU) is a versatile metal scavenger for all forms of palladium and is widely used in the pharmaceutical industry. It works particularly well in organic solvents. It can also be used to scavenge Ag, Pt, Ru, Rh and Hg. Once complexed with a transition metal, it has been reported as being an effective catalyst.

  14. SiliaBond Tosic Acid (SCX) metal scavenger

    SiliaBond® Tosic Acid (SCX)

    SiliaBond Tosic Acid (SiliaBond SCX, Si-TsOH) is a versatile bound strong acid with a pka <<1. It is widely used for the scavenging of amines and other basic functionalities, including weakly basic anilines, borohydrides, and metals such as Ni and Ag. It can also be used as an acid catalyst for organic reactions. Si-TsOH can serve as an alternative method to quench reactions instead of aqueous or organic soluble acids.
  15. SiliaBond® Amine nec

    SiliaBond® Amine nec

    SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.

  16. SiliaMetS metal scavenger kit (K30730B). Includes the following products: Cysteine, DMT, Imidazole, Triamine, TAAcOH, TAAcONa, Thiol & Thiourea

    SiliaMetS® Metal Scavenger Kit (K30730B)

    This metal scavenger kit includes the following products: Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea
  17. SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep™ SPE Cartridges Amine (WAX)

    SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and in normal phase conditions.

  18. SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep™ SPE Cartridges Amine nec (WAX)

    SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.

  19. SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep™ SPE Cartridges Diamine

    SiliaPrep Diamine can be used in replacement of SAX for strong anions. It can also be employed as metal scavenger and in normal phase conditions.

  20. SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep™ SPE Cartridges Diamine nec

    SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.

  21. SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep™ SPE Cartridges Triamine

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  22. SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep™ SPE Cartridges Thiol

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  23. SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep™ SPE Cartridges Thiourea

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  24. SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep™ SPE Cartridges TAAcOH

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  25. SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep™ SPE Cartridges TAAcONa

    SiliaPrep Metal Scavengers will lower the residual metal concentration of variois metal complexes to single digit ppm.

  26. SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep™ SPE Cartridges Dimercaptotriazine (DMT)

    SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.

  27. SiliaPrep™ 96 Well Plates Amine

    SiliaPrep™ 96 Well Plates Amine


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  28. SiliaPrep™ 96 Well Plates Amine nec

    SiliaPrep™ 96 Well Plates Amine nec


    Standard SiliaPrep 96 Well Plates are available in 2 mL with different bed weight up to 200 mg. Various sorbents are available and are divided into several sections based on sorbent characteristics.
  29. SiliaSep™ Flash Cartridges Amine

    SiliaSep™ Flash Cartridges Amine

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

    SiliaSep flash amine cartridges offer a superior alternative to the other cartridges available on the market.

  30. SiliaSep™ Flash Cartridges Triamine

    SiliaSep™ Flash Cartridges Triamine

    SiliaSep flash triamine cartridges offer a superior alternative to the other cartridges available on the market.

  31. SiliaSep™ Flash Cartridges Diamine

    SiliaSep™ Flash Cartridges Diamine

    SiliaSep flash diamine cartridges offer a superior alternative to the other cartridges available on the market.

  32. SiliaSep™ Flash Cartridges Thiol

    SiliaSep™ Flash Cartridges Thiol

    SiliaSep flash thiol cartridges offer a superior alternative to the other cartridges available on the market.

  33. SiliaSep™ Flash Cartridges TAAcOH

    SiliaSep™ Flash Cartridges TAAcOH

    SiliaSep flash TAAcOH cartridges offer a superior alternative to the other cartridges available on the market.

  34. SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep™ Flash Cartridges TAAcONa

    SiliaSep flash TAAcONa cartridges offer a superior alternative to the other cartridges available on the market.

  35. SiliaSep™ Flash Cartridges Thiourea

    SiliaSep™ Flash Cartridges Thiourea

    SiliaSep flash thiourea cartridges offer a superior alternative to the other cartridges available on the market.

  36. SiliaSep™ Flash Cartridges Dimercaptotriazine (DMT)

    SiliaSep™ Flash Cartridges Dimercaptotriazine (DMT)

    SiliaSep flash DMT cartridges offer a superior alternative to the other cartridges available on the market.

  37. SiliaSep™ Flash Cartridges Cysteine

    SiliaSep™ Flash Cartridges Cysteine

    SiliaSep flash cysteine cartridges offer a superior alternative to the other cartridges available on the market .

  38. SiliaSep™ Flash Cartridges - Open Top (OT) Amine

    SiliaSep™ Flash Cartridges - Open Top (OT) Amine

    SiliaSep OT flash cartridges are compatible with FlashMaster instrument.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  39. SiliaSep™ Flash Cartridges - Open Top (OT) Thiol

    SiliaSep™ Flash Cartridges - Open Top (OT) Thiol

    SiliaSep OT flash cartridges are compatible with FlashMaster instrument.

  40. SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine

    SiliaSep BT flash cartridges are compatible with Biotage i-style compression modules.

    Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.

  41. SiliaMetS Novel Scavenger Kit. Includes the following products: AMPA - DEAM - DOTA - DMT - Guanidine - Thiol

    SiliaMetS® Novel Scavenger Kit (K34530B)

    This metal scavenger kit includes the following products: AMPA - DEAM - DOTA - DMT - Guanidine - Thiol
  42. SiliaMetS Tin Metal Scavenger Kit (K34730B) - Includes the following products: Carbonate - Cysteine - DEAM - DMT - TAAcOH - TAAcONa - Thiourea - Thiol

    SiliaMetS® Tin Metal Scavenger Kit (Carbonate; Cysteine; DEAM; DMT; TAAcOH; TAAcONa; Thiol; Thiourea) (K34730B)

    SiliaMetS® Tin Metal Scavenger Kit: Carbonate; Cysteine; DEAM; DMT; TAAcOH; TAAcONa; Thiol; Thiourea
  43. SiliaMetS Palladium Metal Scavenger Kit - Includes: DMT - Diamine - Thiol - Thiourea - Imidazole - Triamine

    SiliaMetS® Palladium Metal Scavenger Kit (K34630B)

    This kit includes the following products : DMT - Diamine - Thiol - Thiourea - Imidazole - Triamine
  44. SiliaBond® Guanidine (R68230B)

    SiliaBond® Guanidine (R68230B)

    SiliaBond®  Guanidine is a silica-supported diisopropylguanidine ligand.

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