SiliaMetS® Calculation of SiliaMetS to Use
To get an effective metal removal, the amount of SiliaMetS Metal Scavenger used is very important. You can determine by two different ways how much scavenger will be needed;
- from the residual concentration (more accurate method)
- from the amount of metal catalyst used (when the residual metal concentration is unknown)
From residual metal concentration (ppm)
Knowing the palladium (Pd) level in 800 g of material is 500 ppm, (the oxidation state does not affect the calculation).
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Data needed:
- Loading of the scavenger (SiliaMetS Thiol): 1.2 mmol/g
- Metal molecular weight: Ex. Pd = 106.42 g/mol
- Amount of product to be treated containing the Pd: Ex. 800 g
- Residual concentration of metal: Ex. 500 ppm of Pd
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1. Determine the amount of palladium to be scavenged |
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2. Calculate the amount of scavenger (SiliaMetS Thiol) to use (1 equivalent) |
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To scavenge 400 mg of palladium, 3.13 g of SiliaMetS Thiol is needed if using only one equivalent. However, it is highly recommend trying a minimum of 4 equivalents at first. In this case, the amount of SiliaMetS Thiol will be 4 times higher (4 x 3.13 g = 12.40 g).
Sometimes, the metal residual concentration is unknown. In such a case, the amount (g) of palladium to be scavenged can be replaced by the amount of metal catalyst used for the reaction:
From amount of metal catalyst used
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Data needed:
- Amount of metal catalyst used: Ex. 10 g of Pd(PPh3)4
- Metal catalyst molecular weight: Pd(PPh3)4 = 1155.56 g/mol
1. Determine the amount of palladium to be scavenged
The amount of SiliaMetS Thiol to be used can then be determined as stated above (see point 2. above). In this particular case, one equivalent of SiliaMetS Thiol corresponds to 7.20 g.
13 Item(s)
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SiliaBond® Amine
SiliaBond® Amine (Si-NH2) is an effective scavenger of acid chlorides, sulfonyl chlorides, isocyanates and other electrophiles. Si-NH2 has been shown to be effective metal scavenger and catalyst for Knoevenagel reactions. SiliaBond Amine is also used in chromatography as normal phase sorbent.
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SiliaMetS® Diamine
SiliaMetS® Diamine (Si-DIA) is a proven scavenger for metals and electrophiles. It scavenges acids, acid chlorides, anhydrides, aldehydes, isocyanates, and chloroformates as well as Pb, Ni, and Cd.
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SiliaSep™ Flash Cartridges Amine
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
SiliaSep flash amine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Triamine
SiliaSep flash triamine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges Diamine
SiliaSep flash diamine cartridges offer a superior alternative to the other cartridges available on the market.
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SiliaSep™ Flash Cartridges - Open Top (OT) Amine
SiliaSep™ OT flash cartridges are compatible with FlashMaster instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Biotage™ Compatible (BT) Amine
SiliaSep™ BT flash cartridges are compatible with Biotage i-style compression modules.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaSep™ Flash Cartridges - Büchi™ Compatible (BU) Amine
SiliaSep™ BU flash cartridges are compatible with Büchi Sepacor flash chromatography instrument.
Good alternative for normal phase purification of compounds with basic properties, which would normally have to be purified by reversed-phase.
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SiliaPrep™ SPE Cartridges Amine (WAX)
SiliaPrep Amine is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Amine nec (WAX)
SiliaPrep Amine nec is a weak anion exchanger sorbent used in replacement of SAX for strong anions to avoid irreversible retention. Can also be employed as a metal scavenger and norman phase conditions.
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SiliaPrep™ SPE Cartridges Diamine
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Diamine nec
SiliaPrep diamine can be used in replacement of SAX for strong anions to be irreversible retention. Can also be employed as metal scavenger and in normal-phase conditions.
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SiliaPrep™ SPE Cartridges Triamine
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.
13 Item(s)
List Grid
- Metal to Remove
- Family / Formats
- Phases
- Pore Size
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- 60 Å (13)
- Endcapping
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- Endcapped (13)
- Non-endcapped (1)
- Cartridges Volume
- Bed Weight
- Particle Size
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