SiliaMetS® Compatible with New Technologies
SiliaMetS In Flow Chemistry
Metal scavenging can also be achieved using SiliaMetS in flow chemistry applications. Simply place SiliaMetSinside solid-phase reactors coming with the flow system (like Syrris Asia® Solid Phase Chemistry Reactors) and let flow the solution to be purified inside these reactors. Multiple reactors can be placed in series and reactors can be heated to obtain optimum scavenging conditions.
SiliaMetS In Microwave
Metal removal using SiliaMetS can also be used under microwave irradiation to provide excellent scavenging efficiency in a few minutes. Simply mix the scavenger and the API dissolved in a suitable solvent inside a microwave tube and set-up the system with the appropriate parameters. Usually, 5 minutes is enough to scavenge all residual metals.
SiliaMetS® TAAcOH (SiliaMetS Triaminetetraacetic Acid) is a silica bound metal scavenger for Pd(0), Ni(0) and Cu. It is the supported version of EDTA in its free form. It is an effective scavenger for metals in low or zero oxidation states, which includes many of the most synthetically useful catalysts such as tetrakis-(triphenylphosphine)palladium(0).
Cysteine - DMT - Imidazole - Triamine - TAAcOH - TAAcONa - Thiol - Thiourea
SiliaSep flash TAAcOH cartridges offer a superior alternative to the other cartridges available on the market.
SiliaPrep Metal Scavengers will lower the residual metal concentration of various metal complexes to single digit ppm.